Navigation Links
Mechanical tissue resuscitation technology shows promise
Date:4/16/2012

WINSTON-SALEM, N.C., April 16, 2012 Wake Forest Baptist Medical Center researchers seeking a successful treatment for traumatic brain injury have found that the size and extent of damaged tissue can be reduced by using a new device to prevent cell death.

The research, the focus of a three-year, $1.5 million study funded by the Department of Defense, was recently published in the journal Neurosurgery. The technology, tested in rats, is called mechanical tissue resuscitation (MTR) and uses negative pressure to create an environment that fosters cell survival.

Louis C. Argenta, M.D., and Michael Morykwas, Ph.D., professors in the Department of Plastic Surgery and Reconstructive Surgery, and a multidisciplinary team of colleagues at Wake Forest Baptist, have more than 15 years of experience working with negative pressure devices to successfully treat wounds and burns. In this study, the team used MTR to remove fluid and other toxins that cause cell death from an injury site deep in the brain.

When the brain is injured by blunt force, explosion or other trauma, the cells at the impact site are irreversibly damaged and die. In the area surrounding the wound, injured cells release toxic substances that cause the brain to swell and restrict blood flow and oxygen levels. This process results in more extensive cell death which affects brain function. Argenta and his team targeted these injured brain cells to determine if removing the fluid and toxic substances that lead to cell death could help improve survival of the damaged cells.

In the study, a bioengineered material matrix was placed directly on the injured area in the brain and attached to a flexible tube connected to a microcomputer vacuum pump. The pump delivered a carefully controlled vacuum to the injured brain for 72 hours drawing fluid from the injury site.

The brain injuries treated with the device showed a significant decrease in brain swelling and release of toxic substances when compared to untreated injuries. Brains treated with the device showed that over 50% more brain tissue could be preserved compared to nontreated animals. Behavioral function tests demonstrated that function was returned faster in the MTR treated group.

"We have been very gratified by the results thus far. This study demonstrates that by working together a multidisciplinary group of researchers can develop new technology that could be used one day at the hospital bedside," said Argenta.

The researchers are now studying the same technology in stroke and brain hemorrhage models.

"The Department of Defense has identified this as an area that is ripe for medical advancement," said study co-author Stephen B. Tatter, MD, Ph.D., professor of neurosurgery at Wake Forest Baptist Medical Center. "We believe it will soon be ready for a clinical trial."


'/>"/>

Contact: Paula Faria
pfaria@wakehealth.edu
336-716-1279
Wake Forest Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Pro Golfers Reveal Biomechanical Differences in Swing
2. Study of golf swings pinpoints biomechanical differences between pros and amateurs
3. Elderly Often Disabled After Mechanical Ventilation
4. Older survivors of mechanical ventilation can expect significant disability
5. Every Day is Earth Day for Plumbing and Mechanical Professionals
6. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
7. From beaker to bits: Collaboration creates computational model of human tissue
8. Transforming scar tissue into beating hearts: The next instalment
9. Obscurins in breast tissue may help physicians predict and detect breast cancer
10. Biologists uncover surprising connection between breast cancer cells and surrounding tissue
11. A new radiotherapy technique significantly reduces irradiation of healthy tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... , ... SuperCloset is proud to officially launch our “Helping Veterans Grow ... and obstacles veterans’ need to overcome in order to face their life changes upon ... veteran(s) with a donated SuperCloset product based on the needs and ability of helping ...
(Date:5/27/2016)... ... ... More than a third of American adults are considered obese, says the ... increased attention in recent years, as an article published May 18th on ... people are familiar with the basic requirements of maintaining a healthy diet and exercise ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute ... for a sustainable product to aid in the rehabilitation process has steadily increased. Ekso ... of individuals with hemiplegia due to stroke. , Ekso Bionics has now received clearance ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, ... ... health care world, this installment is bolstered by inspiring human interest stories, courtesy ... to the developing trends and tech within the industry, from leading advocates and ...
(Date:5/26/2016)... ... ... There are many ways to cook a hot dog, but new research commissioned ... dogs straight off the grill. Of the 90 percent of Americans who say they ... hot dog, far outpacing other cooking methods such as steaming (12 percent), microwaving (9 ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... study highlights the necessity of health literacy within the technology advancement of diagnostic imaging. According ... , a majority of oncology patients undergo imaging screenings without understanding the nuanced risks ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... , May 27, 2016 ... biopharmaceutical company focused on late-stage drug development, today ... Pharma of pivotal batches required for registration ... Administration (FDA). This follows Kitov,s announcement ... trial successfully met its primary efficacy endpoint. ...
(Date:5/26/2016)... 26, 2016 A key trend ... the emergence of new treatments. Cardax, a development stage ... treatment. The therapy is expected to fulfil large unmet ... is conducting studies to develop new treatments for osteoarthritis. ... genes involved in osteoarthritis are being investigated, and early ...
Breaking Medicine Technology: