Navigation Links
Measuring molecules with the naked eye
Date:10/26/2012

When someone develops liver cancer, the disease introduces a very subtle difference to their bloodstream, increasing the concentration of a particular molecule by just 10 parts per billion.

That small shift is difficult to detect without sophisticated lab equipment but perhaps not for long. A new "lab on a chip" designed by Brigham Young University professor Adam Woolley and his students reveals the presence of ultra-low concentrations of a target molecule.

As the BYU researchers report in the journal Analytical Chemistry, their experiments detected as little as a single nanogram one billionth of a gram of the target molecule from a drop of liquid. And instead of sending the sample to a lab for chemical analysis, the chip allows them to measure with such precision using their own eyes.

"The nice thing about the system that we have developed is that this could be done anywhere," Woolley said. "Somebody could put the sample in, look at it, and have the result they need."

The trick is to line a tiny pipe with receptors that catch a specific molecule and allow others to pass by. When a drop of liquid is placed on the clear chip, capillary action draws the fluid through the channel, flowing up to one centimeter per second. As more of the target molecules are snagged by the receptors, the space constricts and eventually stops the flow.

How far the sample flows is a direct indication of the concentration of the target molecule (higher concentration = shorter distance, lower concentration = longer distance).

"The accuracy gained with this system should make it competitive with more expensive and complicated immunoassay systems," said Chuck Henry, a chemist at Colorado State University who was not affiliated with the project.

Woolley and his students hope their prototype will work as a blueprint for making inexpensive diagnostic tests for a variety of diseases and genetic disorders.

"There are a lot of molecules associated with diseases where concentrations around a nanogram per milliliter or less in blood are the difference between a disease state versus a healthy state," Woolley said.


'/>"/>
Contact: Joe Hadfield
joe_hadfield@byu.edu
801-422-9206
Brigham Young University
Source:Eurekalert

Related medicine news :

1. Measuring glucose without needle pricks
2. Measuring the uncertainties of pandemic influenza
3. Prions in the brain eliminated by homing molecules
4. Naked mole-rats may hold clues to pain relief
5. Could the Naked Mole Rat Hold Secrets to Longevity?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... ... Prevent a Warning Letter, **An FDAnews Webinar**, Feb. 23, 2017 — 1:30 p.m. ... distinguish between corrective action (CA) and preventive action (PA)? , The methods share ...
(Date:2/17/2017)... Tx (PRWEB) , ... February 17, 2017 , ... ... revenue cycle management services, announced today that Karen Pilley has been promoted to ... is critical in today’s shifting healthcare paradigm – a shift that demands the ...
(Date:2/17/2017)... GA (PRWEB) , ... February 17, 2017 , ... Like ... to reduce readmissions. Driven in large part by the Hospital Readmission Reduction Program (HRRP), ... been a key focus area for hospitals across the nation. While many providers are ...
(Date:2/16/2017)... York, New York (PRWEB) , ... February 17, ... ... work and determination. After what took over 10 years of research, development and ... technology, NTX Technology™. NTX Technology™ is a patented compound of FDA approved ingredients ...
(Date:2/16/2017)... ... February 16, 2017 , ... As a reflection ... patient care, NWH has achieved Magnet® recognition for the second time, ... 2017. The American Nurses Credentialing Center’s Magnet Recognition Program® distinguishes organizations that meet ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... Feb. 16, 2017 Research and Markets ... Emerging Medical Device Technologies" report to their offering. ... Traditional ... procedures, general instruments, non-drug coated implantables, large endoscopes, needle based ... use over the last two to three decades for the ...
(Date:2/16/2017)... Ontario , Feb. 16, 2017  Aralez Pharmaceuticals ... global specialty pharmaceutical company, today announced that executive management ... Conference to be held February 22-23, 2017. Adrian ... of the Company at 1:35 p.m. local time on ... and audio archive for the event may be accessed ...
(Date:2/16/2017)... , Feb. 16, 2017  AcelRx Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... acute pain, announced that Vincent J. Angotti ... a member of the company,s board of directors, ... over two decades of experience leading executive and ...
Breaking Medicine Technology: