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Measuring medicine: How new technologies could help doctors predict patient outcomes
Date:4/16/2008

s, a technique called microarray analysis was used to build a genetic profile of their tumors. Microarrays allow researchers to look at thousands of genes simultaneously in a particular cell or tissue to determine which are activated at the time of sampling. From these data Molloy and colleagues were able to build a specific genetic fingerprint of breast tumors which may give rise to large numbers of circulating tumor cells.

With this knowledge it was possible to use microarray analysis to predict whether a tumor was likely to disseminate large numbers of tumor cells and therefore metastasize in the future. Testing this on a small independent patient group, researchers found those with a tumor having a genetic profile corresponding to lower levels of circulating tumor cells had a longer time to metastasis at 51.4 months, compared with 29.6 months among those who had a tumor with a genetic profile consistent with higher levels of circulating tumor cells.


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Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

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