Navigation Links
Measuring and modeling blood flow in malaria
Date:11/22/2009

WASHINGTON, D.C. November 18, 2009 -- When people have malaria, they are infected with Plasmodium parasites, which enter the body from the saliva of a mosquito, infect cells in the liver, and then spread to red blood cells. Inside the blood cells, the parasites replicate and also begin to expose adhesive proteins on the cell surface that change the physical nature of the cells in the bloodstream.

Experiments show that infected red blood cells are stiffer and stickier than normal ones -- in the later stages of the disease, up to 10 times stiffer. They also tend to adhere to the endothelial cells lining the vasculature, affecting the normal blood flow. This explains some of the common symptoms of malaria, such as anemia and joint pain.

Sticking to the walls of blood vessels is a survival mechanism for the parasite. In order to develop completely, it needs several days inside a red blood cell. Even though parasitized cells are nearly invisible for the immune system, they may be destroyed in the spleen while circulating freely in the bloodstream.

Doctoral student Dmitry Fedosov and Brown University professor George Karniadakis are studying how malaria infections affect the physical properties of red blood cells, and alter normal blood flow circulation. In particular, they examine an increase in blood flow resistance, and dynamics of infected cells in the bloodstream.

They also monitor the mechanical properties of infected red blood cells by measuring membrane temperature fluctuations, and through the response of a "microbead" that is attached to the cell and twisted. The measured properties are then used in modeling the flow of red blood cells in people infected with malaria. They also collaborate with the group of professor Subra Suresh at MIT, who obtain experimental measurements of the properties and the flow of healthy and infected cells.

"Our model predicts the dynamics of malaria-infected RBCs in the bloodstream, which anticipates the possible course of the disease," says Fedosov.

Recently they found that temperature fluctuations of infected red blood cell membranes measured in experiments are not directly correlated with the reported cell properties, hence suggesting significant influence of metabolic processes. They measured an increase in resistance to blood flow in the capillaries and small arterioles during the course of malaria and found that parasitized red blood cells have a "flipping" motion at the vessel wall that appears to be due to stiffness of the infected cells. The developed models will aid to make realistic predictions of the possible course of the disease, and enhance current malaria treatments.

The talk "Multiscale modeling of blood flow in cerebral malaria" by Dmitry Fedosov, Bruce Caswell, and George Karniadakis is at 6:12 p.m. on Sunday, November 22, 2009.


'/>"/>

Contact: Jason Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. Study says COPD testing is not measuring up
2. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
3. Mastering Challenges & Measuring Successes for Quality Initiatives in Sales, Marketing and Product Development
4. PDSS reliable in measuring impact of sleep disorders on teens academic performance
5. PET Scans Best for Measuring Response to Sarcoma Treatment
6. MEDIA ALERT: Eularis to Address Marketing Return at Measuring Marketing ROI in Pharma Conference in London
7. Measuring medicine: How new technologies could help doctors predict patient outcomes
8. Measuring and Demonstrating the Value of Quality Initiatives
9. New criteria for measuring tumor size and progression will help ease workloads in clinical trials
10. Measuring the impact of electronic medical records
11. Tool Shows Promise for Measuring Productivity of Mid-Level Oncology Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Cirracore Enterprise ... enterprises move workloads to the cloud. Cirracore provides a secure VMware® vCloud ... traversing the Internet. Transformation Solutions (TSL Partners) provides a full range of ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ program into ... prescription referral received at our specialty pharmacy. , “Since our Pay It ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul ... appointment after they noticed their furnace not producing any heat. Shortly after entering the ... cracked heat exchanger was leaking dangerous levels of carbon monoxide into the home, at ...
(Date:2/9/2016)... ... February 09, 2016 , ... The ... Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit the ... Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage Cancer ...
(Date:2/9/2016)... ... 09, 2016 , ... ZipHearing.com is proud to ... hearing aids , increase industry transparency, and promote awareness of hearing solutions ... “For the average consumer, the hearing aid industry is esoteric and difficult to ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- Axovant Sciences Ltd. (NYSE:  AXON), a leading clinical-stage ... today announced further details of three new clinical ... of Lewy body dementia, a disease affecting approximately ... of the three studies were recently initiated and ... quarter. In addition, the Company reported financial results ...
(Date:2/9/2016)... The new report "Global Diagnostic Ultrasound Devices Market Assessment ... reveals that global diagnostic ultrasound devices market was valued at US$ ... million by 2019 at a CAGR of 6.8% from 2015 to ... has been analyzed for six geographies of North America ... , Latin America , Middle-East ...
(Date:2/9/2016)... 2016 The new report "Global Blood Monitoring & Cardiac Monitoring Devices ... Consulting group reveals that global market for blood monitoring & cardiac ... expected to grow to US$ 24,830.1 million by 2019 at a ... America , Europe , Asia-Pacific ... and Africa . The three major ...
Breaking Medicine Technology: