Navigation Links
Measuring and modeling blood flow in malaria
Date:11/22/2009

WASHINGTON, D.C. November 18, 2009 -- When people have malaria, they are infected with Plasmodium parasites, which enter the body from the saliva of a mosquito, infect cells in the liver, and then spread to red blood cells. Inside the blood cells, the parasites replicate and also begin to expose adhesive proteins on the cell surface that change the physical nature of the cells in the bloodstream.

Experiments show that infected red blood cells are stiffer and stickier than normal ones -- in the later stages of the disease, up to 10 times stiffer. They also tend to adhere to the endothelial cells lining the vasculature, affecting the normal blood flow. This explains some of the common symptoms of malaria, such as anemia and joint pain.

Sticking to the walls of blood vessels is a survival mechanism for the parasite. In order to develop completely, it needs several days inside a red blood cell. Even though parasitized cells are nearly invisible for the immune system, they may be destroyed in the spleen while circulating freely in the bloodstream.

Doctoral student Dmitry Fedosov and Brown University professor George Karniadakis are studying how malaria infections affect the physical properties of red blood cells, and alter normal blood flow circulation. In particular, they examine an increase in blood flow resistance, and dynamics of infected cells in the bloodstream.

They also monitor the mechanical properties of infected red blood cells by measuring membrane temperature fluctuations, and through the response of a "microbead" that is attached to the cell and twisted. The measured properties are then used in modeling the flow of red blood cells in people infected with malaria. They also collaborate with the group of professor Subra Suresh at MIT, who obtain experimental measurements of the properties and the flow of healthy and infected cells.

"Our model predicts the dynamics of malaria-infected RBCs in the bloodstream, which anticipates the possible course of the disease," says Fedosov.

Recently they found that temperature fluctuations of infected red blood cell membranes measured in experiments are not directly correlated with the reported cell properties, hence suggesting significant influence of metabolic processes. They measured an increase in resistance to blood flow in the capillaries and small arterioles during the course of malaria and found that parasitized red blood cells have a "flipping" motion at the vessel wall that appears to be due to stiffness of the infected cells. The developed models will aid to make realistic predictions of the possible course of the disease, and enhance current malaria treatments.

The talk "Multiscale modeling of blood flow in cerebral malaria" by Dmitry Fedosov, Bruce Caswell, and George Karniadakis is at 6:12 p.m. on Sunday, November 22, 2009.


'/>"/>

Contact: Jason Bardi
jbardi@aip.org
301-209-3091
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. Study says COPD testing is not measuring up
2. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
3. Mastering Challenges & Measuring Successes for Quality Initiatives in Sales, Marketing and Product Development
4. PDSS reliable in measuring impact of sleep disorders on teens academic performance
5. PET Scans Best for Measuring Response to Sarcoma Treatment
6. MEDIA ALERT: Eularis to Address Marketing Return at Measuring Marketing ROI in Pharma Conference in London
7. Measuring medicine: How new technologies could help doctors predict patient outcomes
8. Measuring and Demonstrating the Value of Quality Initiatives
9. New criteria for measuring tumor size and progression will help ease workloads in clinical trials
10. Measuring the impact of electronic medical records
11. Tool Shows Promise for Measuring Productivity of Mid-Level Oncology Providers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Caloifornia (PRWEB) , ... December 07, 2016 , ... ... present the fifth annual Business Architecture Innovation Summit in Reston, VA on March ... world who will share a range of experiences from a cross-section of industries ...
(Date:12/6/2016)... ... December 06, 2016 , ... People ... can be seen on a type of MRI, according to a study appearing ... of the central nervous system characterized by tremors or trembling and stiffness in ...
(Date:12/6/2016)... ... December 06, 2016 , ... According to a November 1 ... consuming too many mints or not drinking enough water, which can cause bad breath ... Care notes that good oral hygiene not only helps reduce the possibility of bad ...
(Date:12/6/2016)... , ... December 06, 2016 , ... Mount Sinai Health ... the Department of Neurosurgery, where clinicians can confer and order 3D models for their ... low-cost fee-for-service basis with quick turnaround times. This resource will be the first ...
(Date:12/6/2016)... , ... December 06, 2016 , ... CarriersEdge, providers of ... a new suite of Driver Wellness courses. Offered in three modules, the courses can ... point so fleets can educate drivers about how to stay healthy on the road. ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 2016  "Blood Tests replace Surgical Biopsies. Single ... The Diagnostic, Monitoring and Screening Test opportunities are ... occurring using in vitro blood testing to identify ... backing, has announced a single blood test to ... than the market. New technology that definitively identifies ...
(Date:12/6/2016)... -- The pen needles market is projected to reach ... in 2016, growing at a CAGR of 11.2% during ... the years, the pen needles market has witnessed various ... demand for safety injections in the healthcare industry. These ... needles with an aim to reduce pain, increase comfort, ...
(Date:12/6/2016)... -- BTL Aesthetics today announced the release of a ... device was effectively redesigned for more efficient, predictable ... The result: Significantly better outcomes in abdominal fat ... versus BTL Vanquish. "We are committed ... with the most highly-advanced devices on the market," ...
Breaking Medicine Technology: