Navigation Links
Measurements Poor for Assessing Clinical Trials With Children
Date:4/29/2008

Few studies since 1950 had agreement on standard outcomes, review finds

TUESDAY, April 29 (HealthDay News) -- Few studies consider the appropriate measurements for assessing drug clinical trials that enroll children, say University of Liverpool researchers who reviewed 9,000 pediatric clinical trials conducted since 1950.

They also found that few studies have involved parents, and none have involved children in the process to select which measurements to use in assessing clinical trials.

Before they conduct a clinical trial of a new drug, researchers choose several outcomes -- measurements that provide as much information as possible about the drug's safety, effectiveness and impact on the patients' health and daily life, according to background information in the review.

Children's bodies handle drugs very differently than adults' bodies, and it can't be assumed that drugs that work in adults can simply be used in smaller doses to treat children. Pediatric clinical trials need to be designed with these differences in mind.

Of the 9,000 studies, only 25 met the criteria established by the review and examined the selection of outcomes in clinical research in children. The 25 studies came from 13 groups researching a number of conditions, including asthma, cystic fibrosis and Crohn's disease. However, for many conditions that affect children, there has been no work done into the selection of appropriate outcomes for pediatric clinical trials, the review authors said.

They said reaching agreement on standard outcomes for clinical trials in children is important, because it allows comparison and combination of results from different trials. Standardization also helps avoid selectivity and bias in the conduct of research.

The study was published this week in the journal PLoS Medicine.

More information

The U.S. Food and Drug Administration has more about children and clinical trials.



-- Robert Preidt



SOURCE: Public Library of Science, news release, April 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Brain measurements could lead to better devices to move injured or artificial limbs
2. Companies Utilize Variety of Metrics for Quality Measurements
3. MedPAC Again Fails to Evaluate Overall Economic Conditions in Assessing SNF Funding Requirements
4. Extremely low dose CT coronary angiography shows promise in assessing cardiac function
5. Radiologists encouraged to look beyond cancer for clinically unseen diseases
6. Clinical depression linked to abnormal emotional brain circuits
7. Preclinical study suggests organ-transplant drug may aid in lupus fight
8. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
9. Good Clinical Practice Journal Awards: Winners Announced
10. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
11. Study Questions Dead-End Cancer Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... Anyone with a remote control has seen the never-ending twists on ... the flipper will get rich in no time. But what about the buyers of ... for the buyer of a flipped house. An email recently sent to Gary Case ...
(Date:6/28/2017)... , ... June 28, 2017 , ... David B. Sosin, a founding partner ... took over the post of 2nd Vice President for the Illinois State Bar Association ... as the ISBA’s 3rd Vice President in 2016 following a state-wide election and served in ...
(Date:6/28/2017)... ... June 28, 2017 , ... American Farmer proudly announces ... of the award winning television series, scheduled to broadcast fourth quarter 2017. American Farmer ... as a regional supplier of garden pea seed. As demand grew, the small company ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... ZEON) is pleased to announce that a two year study conducted by the ... Bromley Creek zeolite was successful in remediating potash brine-impacted groundwater. As a part ...
(Date:6/28/2017)... ... June 28, 2017 , ... Doner Financial, a Cincinnati ... to insurance assistance and financial planning services, is announcing the commencement of a ... the region facing financial crisis. , Matthew 25: Ministries (M25M) is an international ...
Breaking Medicine News(10 mins):
(Date:6/11/2017)...  Eli Lilly and Company (NYSE: LLY ) ... of galcanezumab, an investigational treatment for the prevention of ... key secondary endpoints for galcanezumab compared to placebo at ... EVOLVE-2 and REGAIN) will be presented today at the ... Boston . "The detailed ...
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... Inc., (Nasdaq: NVAX ) today announced that data ... RSV F protein recombinant nanoparticle vaccine candidate (RSV F Vaccine) ... the journal Vaccine (the data contained ... The Company previously announced top line results from ... F Vaccine with the goal of protecting infants from RSV ...
Breaking Medicine Technology: