Navigation Links
Measles virus may be effective prostate cancer treatment
Date:1/21/2009

Rochester, Minn. January 21, 2009 A new study appearing in The Prostate has found that certain measles virus vaccine strain derivatives, including a strain known as MV-CEA, may prove to be an effective treatment for patients with advanced prostate cancer. The findings show that this type of treatment, called virotherapy, can effectively infect, replicate in and kill prostate cancer cells.

Prostate cancer is a leading cause death among males in the western world. It is currently the second most common cause of cancer-related deaths among American men with 186,320 new cases and 28,660 deaths expected to be recorded in 2008. A sizeable proportion of these patients ultimately relapse, with a 5-year failure rate for treatment ranging from 14 to 34 percent. No curative therapy is currently available for locally advanced or metastatic prostate cancer.

The median survival time of MV-CEA-treated mice in the study almost doubled compared to the controls, and complete tumor regression was observed in one-fifth of treated animals.

"Based on our preclinical results as well as the safety of measles derivatives in clinical trials against other tumor types, these viral strains could represent excellent candidates for clinical testing against advanced prostate cancer, including androgen resistant tumors," says Evanthia Galanis, M.D., of the Mayo Clinic, senior author of the study. The study was supported by the Mayo Clinic Specialized Program of Research Excellence (SPORE) in prostate cancer.

These oncolytic strains of measles virus, represent a novel class of therapeutic agents against cancer that demonstrates no cross-resistance with existing treatment approaches, and can therefore be combined with conventional treatment methods.

Because primary tumor sites are easily accessible in prostate cancer, locally recurrent disease represents a promising target for virotherapy approaches. The virotherapy agent can easily be applied directly to the prostate tumor via ultrasound-guided needle injections and close monitoring of therapy can be achieved by non-invasive techniques including ultrasound and MRI.

The measles vaccine strains also have an excellent safety record with millions of vaccine doses having been safely administered in over 40 years of use. Repeated measurements of the marker CEA (carcinoembryonic antigen, produced when the virus replicates) following MV-CEA treatment can be performed via a simple blood test, and can potentially allow for optimization of dosing as well as the tailoring of individualized treatment. To date, no significant toxicity from MV-CEA treatment of patients with other tumor types has been observed.

Prior studies have demonstrated the therapeutic potency of MV-Edm derivatives against a variety of preclinical animal models including ovarian cancer, glioblastoma multiforme, breast cancer, multiple myeloma, lymphoma and hepatocellular carcinoma.

The promising results prompted the rapid translation of engineered MV-Edm strains in three clinical trials that are currently active. In the ovarian cancer trial, the furthest advanced; evidence of biologic activity has been noted in refractory ovarian cancer patients.

The results set the foundation for additional studies in preparation for using engineered measles strains in a clinical trial for the treatment of patients with advanced prostate cancer.


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.net
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Europe Unlikely to Meet Measles Goals: Report
2. Worldwide Measles Deaths Drop Dramatically
3. Global Measles Deaths Drop By 74%
4. Measles Initiative Supports Disease Prevention for Children in Chinas Earthquake Zone
5. $9 Million Committed to Bolster Worldwide Measles Initiative
6. Study firmly shows no connection between measles, mumps, rubella (MMR) vaccine and autism
7. Measles Cases Highest Since 1996
8. Measles Outbreak Rises to 64 Cases, Most Since 2001
9. CDC Urges Travelers to Israel to Protect Themselves from Measles
10. Government of Madagascar and Coalition of Global Partners Launch Measles and Malaria Prevention Campaign
11. Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... (PRWEB) , ... February 27, 2017 , ... ... San Francisco and environs, is proud to announce an upgrade to the company's ... the upgraded Yelp page on topics as diverse as Platelet Rich Plasma (PRP) ...
(Date:2/26/2017)... ... February 26, 2017 , ... Today, ... the 7th Edition of International Social Design Awards. , The 7th A' ... System Designers, Governments and Institutions worldwide with realized projects and conceptual works. , ...
(Date:2/26/2017)... ... February 26, 2017 , ... LatitudeC ... North America, today announced it would be offering some it’s exclusive product line ... on crafting quality and unique baby clothing/feeding products, will team up with AMAZON ...
(Date:2/26/2017)... , ... February 26, 2017 , ... ODH, Inc.™ ... Summit, February 27-28 at the Sheraton Pentagon City Hotel in Arlington, VA. ODH’s director ... to use behavioral health analytics to improve Medicaid population health management. , ODH will ...
(Date:2/25/2017)... CA (PRWEB) , ... February 25, 2017 , ... FCPX ... ProSharpen Color tools from Pixel Film Studios. With ProSharpen Color users have total control ... to easily refine their color range. With color spectrum tools users can visually see ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... PARSIPPANY, N.J. , Feb. 27, 2017  Interpace ... company that provides clinically useful molecular diagnostic tests and ... to be presented at the upcoming United ... meeting being held March 4-10, 2017 in ... posters reflect a review of data from the Company,s ...
(Date:2/27/2017)... Mass. , Feb. 27, 2017  Infinity Pharmaceuticals, ... at the Cowen and Company 37 th Annual ... p.m. ET in Boston, MA. ... on the Investors/Media section of Infinity,s website at ... following the event. About Infinity,Infinity is an ...
(Date:2/27/2017)... Leading Countries, Technologies and Companies The global ... CAGR of 8.9% from 2016-2021 and CAGR of 9.2% from 2021-2027. ... from 2016 to 2027. The market is estimated at $816m in ... ... to discover how you can exploit the future business opportunities emerging ...
Breaking Medicine Technology: