Navigation Links
McMaster vaccine has pet owners feline groovy
Date:3/31/2011

Hamilton, ON (March 31, 2011) - Good-bye itching, watering eyes and sneezing. McMaster University researchers have developed a vaccine which successfully treats people with an allergy to cats.

Traditionally, frequent allergy shots have been considered the most effective way to bring relief other than getting rid of the family pet -- for the eight to 10% of the population allergic to cats.

Both options one difficult and costly, the other troubling - may now be tossed aside thanks to the work of immunologist Mark Larch, professor in the Department of Medicine in the Michael G. DeGroote School of Medicine and Canada Research Chair in Allergy & Immune Tolerance.

Building on research he's conducted for the past 10 years in Canada and Britain, Larch and his research team have developed a vaccine which is effective and safe with almost no side effects. The research is published in a recent (January 2011) issue of the Journal of Allergy & Clinical Immunology, a leading journal in the allergy field.

The researchers took one protein (molecule) that cats secrete on their fur which causes the majority of allergic problems. Using blood samples from 100 patient volunteers allergic to cats, they deconstructed the molecule and identified short regions within the protein which activate T-cells (helper cells that fight infection) in the immune system.

Using the amino acid code for the whole protein, researchers made synthetic versions of these regions. For the cat allergy vaccine, they found seven peptides (strings of amino acids). "And those synthetic peptides are what we mix together to make the vaccine," said Larch. "We picked the peptides that would work in as much of the population as possible."

Known as "peptide immunotherapy", a low dose of the vaccine is given into the skin. Initially, four to eight doses a year may be required, but the side effects of the traditional allergy shots do not arise, Larch said. The optimal dose will be determined in phase three clinical trials which are getting underway with a much larger group of cat allergy sufferers.

The development of a vaccine to treat people allergic to cats is the first in a line of vaccines developed with Adiga Life Sciences, a company established at McMaster in 2008. It is a joint venture between McMaster University and Circassia Ltd., a UK-based biotech company.

Adiga and McMaster are now collaborating on research into the use of peptide immunotherapy for house dust mite, ragweed, grass, birch tree and moulds.


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related medicine news :

1. Youth with IBD are less fit than their peers: McMaster study
2. McMaster study contradicts reports of problems with blood-thinner
3. McMaster researcher leads development of promising drug for inflammation
4. Scientists find candidate for new TB vaccine
5. New vaccine candidate shows strong potential to prevent highly contagious norovirus
6. Research may lead to new and improved vaccines
7. Sones Innovation Award honors breast cancer vaccine research
8. Using a molecular switch to turn on cancer vaccines
9. An Alzheimers vaccine in a nasal spray
10. Experts explore vaccines: Science, legal, social issues at New York Academy of Sciences
11. New vaccine technology protects mice from hepatitis C virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand ... Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be ... Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ... on fulfilling the promise of precision medicine, today announced ... joined Caris, Precision Oncology Alliance™ (POA) as its 17 ... centers, the St. Jude Crosson Cancer Institute will help ... the use of tumor profiling, making cancer treatment more ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
Breaking Medicine Technology: