Navigation Links
McMaster study contradicts reports of problems with blood-thinner
Date:8/29/2010

New findings by McMaster University researchers contradict earlier reports that people with a certain genetic make-up don't benefit from the blood-thinner clopidogrel, also known as Plavix.

After researchers from the United States, France and Germany reported clopidogrel is less effective in some patients, the Food and Drug Administration (FDA) in the United States issued a black box warning to physicians on the drug's package insert.

"(Our findings) add a further layer of complexity to the FDA 'black box' warning and show that reported genetic variants have no effect in certain patient populations," said Dr. Guillaume Par, lead researcher and assistant professor of pathology and molecular medicine at the Michael G. DeGroote School of Medicine.

Clopidogrel is the world's second best-selling prescription drug with global sales of more than $6 billion annually. It is used in 110 countries by millions of people to reduce the risk of heart attack and stroke.

Following the FDA's warning, clopidogrel became the focus of on-going debates within cardiology circles. Some American cardiologists initially called the FDA's actions irresponsible. Others complained they were left without any appropriate direction on how to manage their patients.

About 20 per cent of the population carry the loss-of-function version of the gene involved in the clopidogrel controversy.

To assess the influence genetics might have on patients prescribed clopidogrel, Par and colleagues from McMaster University conducted a genetic sub-study of 6,000 participants from two major clinical trials (CURE and ACTIVE). The CURE (Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events) trial of 12,562 patients with acute coronary syndrome in 28 countries found clopidogrel significantly reduces the risk of heart attack stroke and dying. The ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for the Prevention of Vascular Events) tr
'/>"/>

Contact: Laura Thompson
lthomp@mcmaster.ca
905-525-9140
McMaster University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. McMaster researcher leads development of promising drug for inflammation
2. Vaccine has cut child cases of bacterial pneumonia, says study
3. Even Before Recession, 14 Million Kids Underinsured: Study
4. Penn study sheds light on how the brain shifts between sleep/awake states under anesthesia
5. Study Links Gene to Serious Eye Disease
6. Study Suggests Statins Could Help Some With Normal Cholesterol
7. Heart Risks the Same With 2 Diabetes Drugs: Study
8. Mayo researchers develop new laboratory cell lines to study treatment for ATC
9. Herpes Drugs Wont Raise Birth Defect Risk, Study Finds
10. Mumps vaccine coverage should be improved, study finds
11. Study Suggests Link Between Diet Sodas, Preterm Delivery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 21, 2015 Henry Mayo Newhall Hospital, ... Care Exchange to automatically send continuation of care ... to further improve communication with clinics and other ambulatory ... Alert solution. , “Provider Alert will enable ... patient information they need to provide continuing care in ...
(Date:4/21/2015)... Among parents of children with autism spectrum disorder, ... or poor, according to a study in the journal ... to the dentist can present many challenges for a ... smells, loud noises, and sharp tools; the unfamiliarity of ... whole process—not knowing what will happen and when it ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Top medical ... in India for their ongoing commitment to providing superior ... strives to provide patients with the best possible experience ... skin, hair and body. , Executives at Ojas Aesthetic ... the philosophy of — nothing about you, without you ...
(Date:4/21/2015)... TX (PRWEB) April 21, 2015 The ... announced today it is opening its first freestanding emergency ... in Chandler, Arizona and will be licensed under Dignity ... the Dignity Health and Adeptus Health joint venture. , ... Regional and Mercy Gilbert Medical Centers said the new ...
(Date:4/21/2015)... Calif. (PRWEB) April 21, 2015 Information is ... , Kevin Ryan, MD, FACP, empowers patients and their families ... Tumor is the Rumor and Cancer is the Answer" and ... authoritative and informative language to guide patients from diagnosis through ... make patients active participants in their treatment, at home and ...
Breaking Medicine News(10 mins):Health News:Henry Mayo Newhall Hospital to Improve Ambulatory Information Sharing with Summit Healthcare's Summit Provider Alert 2Health News:Autism Awareness Month: Dental Care Tips for Children With Autism Spectrum Disorder 2Health News:Autism Awareness Month: Dental Care Tips for Children With Autism Spectrum Disorder 3Health News:Autism Awareness Month: Dental Care Tips for Children With Autism Spectrum Disorder 4Health News:Autism Awareness Month: Dental Care Tips for Children With Autism Spectrum Disorder 5Health News:Autism Awareness Month: Dental Care Tips for Children With Autism Spectrum Disorder 6Health News:VisitandCare.com Cosmetic Surgery Provider in India Earns Recognition for Patient Satisfaction 2Health News:VisitandCare.com Cosmetic Surgery Provider in India Earns Recognition for Patient Satisfaction 3Health News:Dignity Health and Adeptus Health to Open First Freestanding Emergency Room in Chandler, Arizona 2Health News:Dignity Health and Adeptus Health to Open First Freestanding Emergency Room in Chandler, Arizona 3Health News:Authoritative guide and new accompanying therapeutic web portal bridge information gaps in cancer treatment 2
... of Families with Deployed Service Members ... ... $15,000 to the Missouri National Guard -,Missouri Military Family Relief Fund, which will ... Don Brown, market vice president for the central market area at,TriWest, will ...
... Sutter Regional Medical,Foundation,s newly completed third building on ... to a full-range of,state-of-the-art health care services in ... center, located at 2720 Low,Court, replaces the 1234 ... for growth. Designed with comfort and healing in ...
... healthy foods early and often works, research suggests , , MONDAY, ... to love fruits and veggies later in life, offer plenty ... to solid foods, new research suggests. , And mom, eat ... so you,ll help to pass on the preference for these ...
... Ohio, Dec. 3 Seniors who take a close ... Advantage plans may reap,handsome savings next year. Many Medicare ... premiums and $0 deductibles with either complete or,partial coverage ... of their drug bills until reaching $4,050 in out-of-pocket ...
... watery eyes,are often attributed to the common cold, but ... American Academy of Allergy, Asthma &,Immunology (AAAAI)., "Millions ... during the,winter months when they,re actually experiencing allergies," said ... and,allergy symptoms can be very similar, making it hard ...
... services for, at-risk and low-income students to prevent critical health ... ... 3 Approximately 117,000 of Oregon,s,children are uninsured, leaving them ... illness and help them stay in,school. At-risk and low-income children ...
Cached Medicine News:Health News:TriWest Contributes $15,000 to Missouri National Guard Fund 2Health News:Sutter Regional Medical Foundation Opens New Fairfield Care Center 2Health News:Want to Raise a Fruit-and-Veggie Lover? Be Persistent 2Health News:Want to Raise a Fruit-and-Veggie Lover? Be Persistent 3Health News:Want to Raise a Fruit-and-Veggie Lover? Be Persistent 4Health News:HealthMetrix Research Finds Medicare Advantage Plans Offer Seniors Opportunity to Lower Their 2008 Out-of-Pocket Drug Costs 2Health News:HealthMetrix Research Finds Medicare Advantage Plans Offer Seniors Opportunity to Lower Their 2008 Out-of-Pocket Drug Costs 3Health News:Your Stuffy Nose Could Mean More Than a Cold 2Health News:Regence Partners with Multnomah Education Service District to Bring Free Health Services to more than 20,000 Students in Need 2Health News:Regence Partners with Multnomah Education Service District to Bring Free Health Services to more than 20,000 Students in Need 3
(Date:4/21/2015)... Oxfordshire ... than doubled its overseas sales in just 4 years. ... the Queen,s Award for Enterprise, for Outstanding Achievement in ... HealthScience Communications consultancy, helping its clients bring new medicines ... more than doubled its exports in just 4 years, ...
(Date:4/21/2015)... Cardiologists at Henry Ford Hospital have implanted a ... an irregular heartbeat. With only handful of hospitals ... is able to add another option to its arsenal of ... heart,s ability to pump. "This is a ... Watchman implant at a non-clinical trial site," says cardiologist ...
(Date:4/21/2015)... BILLINGS, Mont. , April 21, 2015 /PRNewswire/ ... it comes to patient care. Already following strict ... germ-killing robot Tru-D SmartUVC to eliminate harmful germs, ... Enterobacteriaceae (CRE), influenza and norovirus that can infect patients ... Logo - ...
Breaking Medicine Technology:Queen's Award Crowns Achievements of Local Consultancy 2Queen's Award Crowns Achievements of Local Consultancy 3Queen's Award Crowns Achievements of Local Consultancy 4Queen's Award Crowns Achievements of Local Consultancy 5Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 2Stroke Risk Caused by Abnormal Heart Rhythm Reduced Without Blood Thinners 3St. Vincent Healthcare Deploys Germ-Killing Robot to Prevent Infection, Protect Patients During Hospital Visits 2St. Vincent Healthcare Deploys Germ-Killing Robot to Prevent Infection, Protect Patients During Hospital Visits 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: