Navigation Links
McMaster scientists find protein’s bad guy role in prostate cancer
Date:5/10/2011

Hamilton, ON (May 10, 2011) It's a disease affecting those closest to us our fathers, brothers and sons.

Prostate cancer impacts one in six men in Canada. Last year, roughly 24,600 men were diagnosed with the disease.

Most types of prostate cancer are curable if caught and treated early. But little is understood about the mechanisms that cause a tumour to metastasize and spread to other parts of the body.

Damu Tang, an associate professor of medicine in the Division of Nephrology of the McMaster University's Michael G. DeGroote School of Medicine and St. Joseph's Healthcare Hamilton, has spent nearly a decade and searched more than a million genes to better understand the molecular underpinnings of prostate cancer progression.

His research, published today in Nature Communications, shows for the first time the role of a specific protein MAN2C1 in prostate cancer development. The finding is significant because prostate cancer patients with increased levels of MAN2C1 appear to face more aggressive forms of the disease.

"This research could serve a diagnostic purpose in terms of likelihood of whether prostate cancers at early stages will progress into metastatic tumours," said Tang, who has a joint appointment in the Division of Urology, Department of Surgery at McMaster. "Patients with high levels of MAN2C1 may need more aggressive therapies when their cancers are still at early stages in order to prevent the development of metastatic cancer."

It's been known for some time that another protein, PTEN, is a powerful tumour suppressor. Clinical observations have shown that half of advanced prostate cancers either have no PTEN or reduced PTEN function.

Tang and his research team set out to understand how PTEN function becomes impaired in advanced prostate cancers. In the process, they discovered MAN2C1 and the role it plays in reducing PTEN function.

The research group found increases in the MAN2C1 protein in PTEN-positive prostate cancer cells dramatically increased the likelihood of cancers forming in mice. Additional research showed that in 659 prostate cancer patients, approximately 60 per cent of their prostate tumors had normal PTEN. Among these tumors, 80 per cent had increased MAN2C1.

The researchers concluded that increases in MAN2C1 in PTEN-positive prostate cancers enhance prostate cancer recurrence, meaning that patients with high levels of MAN2C1 have an increased risk of their tumors developing into metastatic cancer.

The next step for the researchers will be to look for ways to block the ability of MAN2C1 to impair PTEN function, Tang said. That could lead to the development of new therapies for patients with prostate cancer.


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
905-525-9140 x22169
McMaster University
Source:Eurekalert

Related medicine news :

1. McMaster researcher leads development of promising drug for inflammation
2. McMaster study contradicts reports of problems with blood-thinner
3. Youth with IBD are less fit than their peers: McMaster study
4. McMaster vaccine has pet owners feline groovy
5. Scientists Pinpoint Area of Brain That Fears Losing Money
6. Scientists Discover How HIV Is Transmitted Between Men
7. Prevention Is Key Research Goal for Premature Babies, Scientists Say
8. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
9. Scientists find donut-shaped structure of enzyme involved in energy metabolism
10. Neuroscientists reveal new links that regulate brain electrical activity
11. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Intalere’s ... together more than 200 of the country’s top healthcare executives to share insights ... true benefit of the Forum is the provider-centric perspective, experience, expertise and strategy ...
(Date:2/10/2016)... ... February 10, 2016 , ... Armune BioScience signed a ... network of laboratory service centers across the country. Launched in April of 2015, Apifiny ... detection of prostate cancer. Apifiny order volume exceeded 3,000 tests in 2015. Primary care ...
(Date:2/10/2016)... ... February 10, 2016 , ... A ... Ohio Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau ... Center. , As the longest running and largest worker's compensation event in ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... 1 UNF Drive, Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions ... Division - Time: 7:00pm – 10:00pm | Ticket Prices $30, Social Media: ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans ... start of Medicare Part D a decade ago, according to The Senior Citizens ... adults on how they are coping with rapidly rising costs. “The implications are ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016  Resolve Therapeutics, ... transformative new approaches to the treatment of lupus ... of a multiple ascending dose study in patients ... compound RSLV-132. --> ... placebo-controlled multiple ascending dose study of RSLV-132 in ...
(Date:2/10/2016)...  Rich Pharmaceuticals, Inc. (OTC Markets: RCHA) ("Rich Pharmaceuticals" ... of its issued and outstanding shares of common stock ... 11, 2016. The Company,s common stock will trade on ... temporary ticker symbol "RCHAD". After 20 trading days, the ... (RCHA).  --> --> ...
(Date:2/10/2016)... , Feb. 10, 2016  The Baylor ... received an in-kind gift from ... VeinViewer® Vision vein finder for the nursing ... students as they learn how to start ... with traditional technique. ...
Breaking Medicine Technology: