Navigation Links
McMaster researchers discover a new antibacterial lead
Date:9/27/2009

(Hamilton, Ontario Sept. 25, 2009) - Antibiotic resistance has been a significant problem for hospitals and health-care facilities for more than a decade. But despite the need for new treatment options, there have been only two new classes of antibiotics developed in the last 40 years.

Now a promising discovery by McMaster University researchers has revealed an ideal starting point to develop new interventions for resistant infections.

Eric Brown, a professor and chair of the Department of Biochemistry and Biomedical Sciences, and a team of researchers from the Michael G. DeGroote Institute for Infectious Disease Research have identified a novel chemical compound that targets drug-resistant bacteria in a different way from existing antibiotics. The discovery could lead to new treatments to overcome antibiotic resistance in certain types of microorganisms.

The findings were published September 27 in the science research journal Nature Chemical Biology.

"Everyone reads the headlines about drug-resistant bugs, it's a big problem," said Brown, who holds the Canada Research Chair in Antimicrobial Research. "Really what we're trying to do is understand whether or not there are new ways to tackle this problem."

The research team, which included biochemists and chemists from McMaster University, used high-throughput screening to uncover the new class of chemical. The approach allows scientists to look for small molecules that kill bacteria as well as examine the molecular mechanisms and pathways they exploit.

Existing antibiotics destroy bacteria by blocking production of its cell wall, DNA or protein. The new McMaster-discovered compound, MAC13243, is directed at blocking a particular step in the development of the bacteria's cell surface, which until now has not been recognized as a target for antibiotics.

"We're excited about finding a new probe of a relatively uncharted part of bacterial physi
'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. TB vaccine developed at McMaster University in Canada
2. McMaster study sheds light on how stem cells develop into blood cells
3. Mayo Clinic, McMaster University Research Review Shows Internet-based Instruction Effective for Teaching Health Care Professionals
4. McMaster test detects the most prevalent respiratory viruses
5. BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
6. UCI researchers create new strategy for highly selective chemotherapy delivery
7. UCI researchers create new strategy for highly-selective chemotherapy delivery
8. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
9. VA Honors Eye Researchers With Olin Teague Award
10. Researchers find drug-eluting stents safe, effective for PCI in diabetics
11. Researchers Propose Improved Cervical Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... NH (PRWEB) May 24, 2015 ... leather, launches “InkGard™ Plus” – a classic, rugged ... the polymer allowing difficult stains, including ink, to ... 16 different colors suitable for corporate, healthcare, hospitality ... in line with EnviroLeather’s goal of developing products ...
(Date:5/24/2015)... WI (PRWEB) May 24, 2015 ... Health System CEO - The ... and honored at the fourth annual ... April 15 at Geneva National in ... school): ,     -Badger High School,         Jonathan ...
(Date:5/23/2015)... May 23, 2015 With the implementation ... are finding it increasingly difficult to provide their employees ... to provide adequate insurance for employees stand to face ... such an integral part of a business’s success or ... for businesses, Online USA Doctors has created a varying ...
(Date:5/23/2015)... (PRWEB) May 23, 2015 Javon ... at the Sports Medicine and Rehabilitation Center, 557 N. ... program, Mondays, June 1-July 20, 5:30-6:30 pm. , The ... coach, and Laurie Finke, RN, BSN, who will offer ... education on nutrition, running mechanics and show selection and ...
(Date:5/22/2015)... CA (PRWEB) May 22, 2015 The ... two exciting events in June. They will hold a ... Doctorate and a two-day class on Classical Chinese Medicine. ... June 3, Dr. Steve Given, the Dean of Clinical ... discuss the new First Professional Doctorate program. ACTCM is ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3Health News:ACTCM Announces Upcoming June Events 2
... The Sheffield University's researchers have developed a fertility predictor ... whether their fertility is increasing or decreasing. This will ... in for late marriages. The best age for child ... according to Professor Bill Ledger of the Sheffield University. ...
... A DNA study conducted at the burial pits of ancient ... large-scale devastation to the city. The Golden Age of Athens ... this // epidemic, which is said to have wiped out ... epidemic was in Ethiopia, between 430-426 BC, which later spread ...
... to start “Hope Lodges” near major cancer hospitals to ... getting treatment in these major cancer hospitals//. ... patients who are coming from far off distances to ... facilities to these patients during their treatment which would ...
... at Swansea psychiatric hospital, it is said that patients are not ... kitchens at Cefn Coed Hospital//. ,The claims made say that ... kitchens at Cefn Coed Hospital. , ,The closure of the ... what it called a "cook chill" system. , ,The bone ...
... clear to 21 women who had breast cancer. A report ... and surviving the disease//. ,It is reported that ... was given a clean chit by the radiologist, who is ... radiologist worked at Trafford General and the North Manchester General ...
... been mostly caused by tobacco chewing and smoking. Non Small ... which has found to have little disease prognosis to cancer ... the disease and the survival rate of patients more than ... and his team of radiation oncologist from Peter MacCallum Cancer ...
Cached Medicine News:
(Date:5/22/2015)... May 22, 2015   InspireMD, Inc. (NYSE MKT: ... protection systems ("EPS"), today announced that its CGuard TM ... principle investigator Prof. Piotr Musialek , at the ... Paris, France . PARADIGM, an investigator-initiated ... c A roti D revascularization I n symptomatic ...
(Date:5/22/2015)... 2015 Richmond Pharmacology is ... with a worldwide reputation for excellence in clinical ... in peer reviewed medical journals. Its officers are ... in discussions about rules for transparency and publication ... http://photos.prnewswire.com/prnh/20150522/745125) , Clinical research is conducted ...
(Date:5/21/2015)... May 21, 2015  When Ryan Rendino ... side of his neck, he figured it ... couple weeks off from weight lifting. ...                               A series of ... referred to Michel Kliot, MD , ...
Breaking Medicine Technology:InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: