Navigation Links
McMaster researchers discover a new antibacterial lead
Date:9/27/2009

(Hamilton, Ontario Sept. 25, 2009) - Antibiotic resistance has been a significant problem for hospitals and health-care facilities for more than a decade. But despite the need for new treatment options, there have been only two new classes of antibiotics developed in the last 40 years.

Now a promising discovery by McMaster University researchers has revealed an ideal starting point to develop new interventions for resistant infections.

Eric Brown, a professor and chair of the Department of Biochemistry and Biomedical Sciences, and a team of researchers from the Michael G. DeGroote Institute for Infectious Disease Research have identified a novel chemical compound that targets drug-resistant bacteria in a different way from existing antibiotics. The discovery could lead to new treatments to overcome antibiotic resistance in certain types of microorganisms.

The findings were published September 27 in the science research journal Nature Chemical Biology.

"Everyone reads the headlines about drug-resistant bugs, it's a big problem," said Brown, who holds the Canada Research Chair in Antimicrobial Research. "Really what we're trying to do is understand whether or not there are new ways to tackle this problem."

The research team, which included biochemists and chemists from McMaster University, used high-throughput screening to uncover the new class of chemical. The approach allows scientists to look for small molecules that kill bacteria as well as examine the molecular mechanisms and pathways they exploit.

Existing antibiotics destroy bacteria by blocking production of its cell wall, DNA or protein. The new McMaster-discovered compound, MAC13243, is directed at blocking a particular step in the development of the bacteria's cell surface, which until now has not been recognized as a target for antibiotics.

"We're excited about finding a new probe of a relatively uncharted part of bacterial physiology," Brown said. "It's a new way of thinking about the problem. Who knows, could this chemical become a drug? Anything's possible. But at the very least we've advanced the field and created some tools that people can use now to try to better understand this pathway."


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related medicine news :

1. TB vaccine developed at McMaster University in Canada
2. McMaster study sheds light on how stem cells develop into blood cells
3. Mayo Clinic, McMaster University Research Review Shows Internet-based Instruction Effective for Teaching Health Care Professionals
4. McMaster test detects the most prevalent respiratory viruses
5. BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
6. UCI researchers create new strategy for highly selective chemotherapy delivery
7. UCI researchers create new strategy for highly-selective chemotherapy delivery
8. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
9. VA Honors Eye Researchers With Olin Teague Award
10. Researchers find drug-eluting stents safe, effective for PCI in diabetics
11. Researchers Propose Improved Cervical Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... ... Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions - Time: 7:00pm ... 7:00pm – 10:00pm | Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , ...
(Date:2/10/2016)... DC (PRWEB) , ... February 10, 2016 , ... Anxiety ... level since the start of Medicare Part D a decade ago, according to ... comments from older adults on how they are coping with rapidly rising costs. ...
(Date:2/10/2016)... ... February 09, 2016 , ... According to a recent article ... in the number of patients under the age of 30. According to Southern California ... their offices, and may indicate an overall shift in the rapidly growing social acceptance ...
(Date:2/9/2016)... ... February 09, 2016 , ... Center for ... are diagnosed with autism spectrum disorder (ASD). Beginning Jan. 1, 2016, Medicaid is ... behavior analysis (ABA) is key to providing effective treatment for individuals with ASD. ...
(Date:2/9/2016)... ... 2016 , ... A new study from the Workers Compensation ... for a variety of medical services in Illinois as of 2015. , ... Schedule Rates in Illinois, are professional medical services, hospital outpatient and ambulatory ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 The new report "Global Blood Monitoring ... Acuity Business Research & Consulting group reveals that global market for ... million in 2014 and expected to grow to US$ 24,830.1 million ... North America , Europe ... , Middle-East and Africa ...
(Date:2/9/2016)... BRUNSWICK, N.J. , Feb. 9, 2016  Johnson ... the RBC Capital Markets Global Healthcare Conference on Tuesday, ... York City.  Dominic Caruso , Vice President, Finance ... Worldwide Chairman, Consumer will represent the Company in a ... www.investor.jnj.com . --> www.investor.jnj.com . ...
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
Breaking Medicine Technology: