Navigation Links
McMaster researchers discover a new antibacterial lead
Date:9/27/2009

(Hamilton, Ontario Sept. 25, 2009) - Antibiotic resistance has been a significant problem for hospitals and health-care facilities for more than a decade. But despite the need for new treatment options, there have been only two new classes of antibiotics developed in the last 40 years.

Now a promising discovery by McMaster University researchers has revealed an ideal starting point to develop new interventions for resistant infections.

Eric Brown, a professor and chair of the Department of Biochemistry and Biomedical Sciences, and a team of researchers from the Michael G. DeGroote Institute for Infectious Disease Research have identified a novel chemical compound that targets drug-resistant bacteria in a different way from existing antibiotics. The discovery could lead to new treatments to overcome antibiotic resistance in certain types of microorganisms.

The findings were published September 27 in the science research journal Nature Chemical Biology.

"Everyone reads the headlines about drug-resistant bugs, it's a big problem," said Brown, who holds the Canada Research Chair in Antimicrobial Research. "Really what we're trying to do is understand whether or not there are new ways to tackle this problem."

The research team, which included biochemists and chemists from McMaster University, used high-throughput screening to uncover the new class of chemical. The approach allows scientists to look for small molecules that kill bacteria as well as examine the molecular mechanisms and pathways they exploit.

Existing antibiotics destroy bacteria by blocking production of its cell wall, DNA or protein. The new McMaster-discovered compound, MAC13243, is directed at blocking a particular step in the development of the bacteria's cell surface, which until now has not been recognized as a target for antibiotics.

"We're excited about finding a new probe of a relatively uncharted part of bacterial physiology," Brown said. "It's a new way of thinking about the problem. Who knows, could this chemical become a drug? Anything's possible. But at the very least we've advanced the field and created some tools that people can use now to try to better understand this pathway."


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related medicine news :

1. TB vaccine developed at McMaster University in Canada
2. McMaster study sheds light on how stem cells develop into blood cells
3. Mayo Clinic, McMaster University Research Review Shows Internet-based Instruction Effective for Teaching Health Care Professionals
4. McMaster test detects the most prevalent respiratory viruses
5. BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
6. UCI researchers create new strategy for highly selective chemotherapy delivery
7. UCI researchers create new strategy for highly-selective chemotherapy delivery
8. Pancreatic cancer: Researchers find drug that reverses resistance to chemotherapy
9. VA Honors Eye Researchers With Olin Teague Award
10. Researchers find drug-eluting stents safe, effective for PCI in diabetics
11. Researchers Propose Improved Cervical Cancer Screening
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... Rosa, California (PRWEB) , ... May 23, 2017 ... ... health management (PHM) technology and a 2017 Best in KLAS category winner, has ... advantageous market position to extend and enhance its technology platform and product offerings,” ...
(Date:5/23/2017)... Rosa, CA (PRWEB) , ... May 23, 2017 , ... ... mosquito season underway in Sonoma County. While officials call for diligence, asking homeowners to ... are looking at potential health concerns. Along with the annoying buzz of mosquitos is ...
(Date:5/23/2017)... ... ... New patients from Charleston, SC, are now welcome to receive a full ... with or without a referral. A full mouth reconstruction can transform the appearance of ... Charleston, SC. Those who suffer from gum disease, misaligned teeth or jaw pain can ...
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart ... in an infographic on the current state of anxiety in support of National Mental ... was conducted in April 2017 and benchmarked general anxiety levels as well as identified ...
(Date:5/22/2017)... (PRWEB) , ... May 22, 2017 , ... ... Periodontics, is now welcoming new patients with periodontal plastic surgery treatments, including ... a general dentist. Dr. Green provides these esthetic and functional procedures to help ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)... , May 12, 2017  The China and ... washing technology that consumes less water, energy and detergent, and features ... first product LaughingU, a shoebox-sized washing machine that washes and sanitizes ... ... Product, LaughingU, is compact, and does not require an external water ...
(Date:5/10/2017)... , May 10, 2017  The Corporate Whistleblower ... employees of sleep therapy clinics to call us ... therapy clinic is involved in a substantial scheme ... in hearing from an employee of a medical ... a kickback scheme to provide medical practice groups with ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its commitment ... of directors for the Pharmaceutical Research and Manufacturers ... membership. Biopharmaceutical companies will now have to meet ... to be eligible to join PhRMA. ... board is sending a clear message that being ...
Breaking Medicine Technology: