Navigation Links
McMaster researcher leads development of promising drug for inflammation
Date:3/30/2010

Hamilton, ON (March 30, 2010) Aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) remain the most common treatment to relieve symptoms of arthritis and other inflammatory disorders. But despite their widespread use (around 2.5 million Canadians have osteoarthritis) these medications are also known to cause severe, sometimes life-threatening adverse effects within the body, particularly in the gastrointestinal tract.

A novel anti-inflammatory drug being developed and commercialized by an inflammation expert at McMaster University has shown promise in relieving symptoms of inflammation, while substantially reducing the incidence of bleeding and intestinal damage often caused by NSAIDs.

The research is published in the March issue of the British Journal of Pharmacology.

John Wallace, a pharmacologist and director of the Farncombe Family Digestive Health Research Institute at McMaster University, compared naproxen, a commonly used NSAID, to a novel anti-inflammatory drug, ATB-346, which he developed in collaboration with a team of Italian chemists and is now commercializing through his company, Antibe Therapeutics Inc.

ATB-346 is a derivative of naproxen which releases hydrogen sulfide. Evidence from animal studies suggests that in small quantities, hydrogen sulfide can protect the stomach from injury and can accelerate the healing of pre-existing ulcers.

"I've been working on NSAIDs for over 20 years," said Wallace, a professor of medicine in the Michael G. DeGroote School of Medicine at McMaster University. "This particular drug is, by far, the shining star. We've tested it in every model where it should fail, and it has performed exceptionally well."

To examine the gastrointestinal safety and anti-inflammatory effectiveness of ATB-346, Wallace and his co-investigators tested the drug in healthy rats as well as those with arthritis and inflammation. The researchers also examin
'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Concussions not taken seriously enough: McMaster researcher
2. National Press Club to Host NEWSMAKER Media Briefing on Cornhusker Kickback With South Carolina Attorney General Henry McMaster
3. New drug shows promise for those with clotting disorders: McMaster researcher
4. Researchers identify potential new target for treating hepatitis C
5. Researchers Identify 2 Genes Linked to Fatty Liver Disease
6. NIA researchers find gene to explain mouse embryonic stem cell immortality
7. Researchers discover fundamental step in immune-system development
8. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
9. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
10. BUSM researcher receives prestigious young investigator award
11. Researchers find new chemotherapy combination shows promise in endometrial cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 Hamilton Facial ... of its new Carmel office on July 30th. After ... finally be moving to the state-of-the-art suite, located only ... innovative space will allow for one-on-one patient comfort, shorter ... experience. , Dr. Hamilton’s new office-suite will continue ...
(Date:7/30/2014)... DRE Medical — a leading medical ... of its Medical Trade Shows & Conventions Calendar ... and equipment vendors. , The calendar is a continually-updating ... United States and around the world. Hundreds of entries ... is always growing. , Information listed on each trade ...
(Date:7/30/2014)... The Technology Association of Georgia in collaboration with ... issued its final call for applications and nominations for ... until August 29th 2014 to be considered for this ... the Excalibur Judging Committee. Companies selected as semi-finalists will ... interviewing process. , The TAG Excalibur Awards recognize ...
(Date:7/30/2014)... LTC Consumer, an independent, free online service to help ... Instant Quote tool on its website, LTCconsumer.com , announced ... are free and unlimited. , The Instant Quote tool ... including age, gender, and state of residence – and delivers ... to enter any contact information to get started). There is ...
(Date:7/30/2014)... July 30, 2014 Children’s Hospital of ... Safety Day from 4 p.m. to 7 p.m. Wednesday, ... 7 Mile Road, Livonia, MI 48152). The event will ... helmets, children’s activities, music, snacks and local public safety ... the Children’s Hospital of Michigan Foundation. , The ...
Breaking Medicine News(10 mins):Health News:Hamilton Facial Plastic Surgery Opens New Carmel Office 2Health News:DRE Launches Online Interactive Medical Trade Show Calendar 2Health News:Last Call for TAG 2014 Excalibur Awards Nominations and Applications 2Health News:Last Call for TAG 2014 Excalibur Awards Nominations and Applications 3Health News:LTC Consumer Launches Online Tool for Getting Instant Long Term Care Insurance Estimates 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 2Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 3Health News:Kohl’s, Children’s Hospital of Michigan Foundation Host Safety Day with Detroit Red Wings Defenseman Danny DeKeyser, Bike Helmets, Family Activities and More 4
... -- About 14 percent of strokes happen while people are ... to the hospital in time for a potentially brain-saving treatment, ... for ischemic stroke must be given within a few hours ... stroke symptoms often can,t receive the treatment since we can,t ...
... new to adolescents, researchers and physicians at Nationwide Children,s ... that is raising some concern among medical professionals. Often ... form of self-injurious behavior that involves inserting foreign objects ... into muscle. A recent study, published in the June ...
... prevalence of overall cardiovascular risk in the Spanish working population ... (8% on men and 2% in women). This prevalence increases ... farming sector, followed by construction, industry and services. "In ... of cardiovascular risk, but only a minority of these people ...
... ROCHESTER, Minn. - Constipation is definitely not a glamorous ... and costs more than $1 billion annually to evaluate ... bloating, discomfort, and straining associated with constipation lead sufferers ... researchers recently had success in the clinical trial of ...
... By Steven Reinberg HealthDay Reporter , MONDAY, May ... associated with a lethal nervous system disease known as amyotrophic ... explain, however, that this does not mean people with long ... they are at higher risk for it. "We have ...
... of U.S. veterans ages 70 and older finds that the ... methods. However, for many less healthy veterans the burdens of ... we really need to target screening in older adults, so ... while those who won,t benefit aren,t exposed to unnecessary burdens," ...
Cached Medicine News:Health News:Research Suggests 1 in 7 Strokes Happens During Sleep 2Health News:A new study on self-injury behavior encourages quick and targeted intervention 2Health News:6 percent of Spanish workers have high cardiovascular risk 2Health News:Mayo Clinic researchers find new treatment for constipation 2Health News:Ring Finger Length Linked to ALS, Study Suggests 2Health News:Ring Finger Length Linked to ALS, Study Suggests 3Health News:Blood test for colon cancer screening beneficial for some seniors, but not for many others 2
(Date:7/30/2014)... 30, 2014 Research and Markets has announced ... Forecasts to 2019" report to their offering. ... to grow at a lower CAGR in developed countries; however, it ... China , India , and ... The growth of the hematology analyzers and reagents market is ...
(Date:7/30/2014)... , July 30, 2014 Research ... "Global and Chinese Aseptic Packaging Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 The Global and Chinese ... study on the current state of the global Aseptic ... The report provides a basic overview of the ...
(Date:7/30/2014)... 30, 2014   Unique Pizza and Subs ... Pink: UPZS), a Delaware Corporation, is pleased to ... Larasan Pharmaceutical Corporation ("Larasan"), a nature-based pharmaceutical company that ... agreement, US-based Larasan will work with Unique to ... through Larasan,s vast distribution network throughout ...
Breaking Medicine Technology:Hematology Analyzers & Reagents Market - Forecasts to 2019 2Global and Chinese Aseptic Packaging Industry Report 2014 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 2Unique Pizza and Subs Announces Asian Distribution Agreement with Larasan Pharmaceutical Corporation 3
... NEW YORK, Nov. 2, 2011 ... new market research report is ... Interventional Cardiology Devices: ... http://www.reportlinker.com/p0663863/Interventional-Cardiology-Devices-World-Market-Prospects-2011-2021.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=General_Medicine_and_Specialty_Medicine ...
... sustain medical innovation, the FDA must accelerate the adoption ... regulatory process, said John Lechleiter, Ph.D., chairman, president and ... In an address at the FDA ... Summit, Lechleiter called for a regulatory process that focuses ...
Cached Medicine Technology:Interventional Cardiology Devices: World Market Prospects 2011-2021 2Interventional Cardiology Devices: World Market Prospects 2011-2021 3Interventional Cardiology Devices: World Market Prospects 2011-2021 4Interventional Cardiology Devices: World Market Prospects 2011-2021 5Interventional Cardiology Devices: World Market Prospects 2011-2021 6Interventional Cardiology Devices: World Market Prospects 2011-2021 7Interventional Cardiology Devices: World Market Prospects 2011-2021 8Interventional Cardiology Devices: World Market Prospects 2011-2021 9Interventional Cardiology Devices: World Market Prospects 2011-2021 10Interventional Cardiology Devices: World Market Prospects 2011-2021 11Interventional Cardiology Devices: World Market Prospects 2011-2021 12Interventional Cardiology Devices: World Market Prospects 2011-2021 13Interventional Cardiology Devices: World Market Prospects 2011-2021 14Lilly CEO Says Appropriate Assessment of Both Benefits and Risks Critical in Regulatory Process 2Lilly CEO Says Appropriate Assessment of Both Benefits and Risks Critical in Regulatory Process 3
... premium product for acne, XtremeClear, powered ... on a scalable multi-application platform. A ... acne, XtremeClear works fast, providing noticeable ... treatments. Uncompromising safety in each of ...
... SpaTouch was designed specifically to meet the varying ... is a simple to use, compact, dual application ... lucrative field of light based hair removal. SpaTouch ... is safe for use on nearly all face ...
... all of the benefits and functionality ... the additional feature of being able ... scanner for importing and storage of ... images. This additional feature allows for ...
Inquire...
Medicine Products: