Navigation Links
McGill researchers report breakthrough in rapid malaria detection
Date:12/19/2007

A research team led by Dr. Paul Wiseman of the Departments of Physics and Chemistry at McGill University has developed a radically new technique that uses lasers and non-linear optical effects to detect malaria infection in human blood, according to a study published in the Biophysical Journal. The researchers say the new technique holds the promise of simpler, faster and far less labour-intensive detection of the malaria parasite in blood samples.

Malaria is a vector-borne infectious disease spread by parasites of the genus Plasmodium. Most common in tropical and subtropical regions, it is a global scourge with 350 to 500 million new cases and one to three million fatalities reported annually. Most of the fatalities are concentrated in sub-Saharan Africa, where the resources and trained personnel currently required to accurately diagnose the disease are spread the thinnest.

Current detection techniques require trained technicians to stain slides, look for the parasites DNA signature under the microscope, and then manually count all the visible infected cells, a labourious process dependent on the skill and availability of trained analysts. By contrast, the proposed new technique relies on a known optical effect called third harmonic generation (THG), which causes hemozoin a crystalline substance secreted by the parasite to glow blue when irradiated by an infrared laser.

People who are familiar with music know about acoustic harmonics, said Dr. Wiseman. "You have a fundamental sound frequency and then multiples of that frequency. Non-linear optical effects are similar: if you shine an intense laser beam of a specific frequency on certain types of materials, you generate multiples of the frequency. Hemozoin has a huge, non-linear optical response for the third harmonic, which causes the blue glow."

Dr. Wiseman and his colleagues now hope to adapt well-established existing technologies like fibre-optic communications lasers and fluorescent cell sorters to quickly move the technique out of the laboratory and into the field.

"Were imagining a self-contained unit that could be used in clinics in endemic countries," said Dr. Wiseman. "The operator could inject the cell sample directly into the device, and then it would come up with a count of the total number of existing infected cells without manual intervention."


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related medicine news :

1. McGill researchers link enzyme to breast cancer malignancy
2. Stanford researchers find culprit in aging muscles that heal poorly
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. Jefferson immunology researchers halt lethal rabies infection in brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... ... July 26, 2017 , ... An inventor from Salisbury, N.C., knows the difficulties ... an effective and dignified way to keep leeches in place during therapy," she said. ... invention provides an effective way to keep a leech in place on the skin ...
(Date:7/26/2017)... ... July 26, 2017 , ... Written By: Ashley D. Beall, ... in drug therapy for patients living with relapsing and primary multiple sclerosis that ... cell targeted therapy that has been proven to significantly reduce signs of disease ...
(Date:7/26/2017)... ... July 26, 2017 , ... Evergreen Healthcare Partners is ... continued efforts to provide innovative offerings to their healthcare partners. These solutions will ... dynamic, high-performing teams to address healthcare IT’s biggest challenges. , “Adding Talent Management ...
(Date:7/26/2017)... ... , ... It may be hard to imagine that the basic necessities that ... world. Diseases that many developed countries consider rare or eradicated, like measles, are still ... , On an upcoming segment of "Success Files", actor Rob Lowe will introduce a ...
(Date:7/26/2017)... ... July 26, 2017 , ... The ... Process Validation and Process Validation Statistics Conferences in Bethesda, Maryland, 12 – ... challenges faced by process validation professionals and statisticians today. , “These conferences ...
Breaking Medicine News(10 mins):
(Date:7/24/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ) ... 2017 operating results on Monday, August 7, 2017 after ... 5:00 p.m. ET. ... broadcast of the conference call by dialing 877-201-0168 or ... approximately 15 minutes prior to the call. A live ...
(Date:7/21/2017)... and RESEARCH TRIANGLE PARK, N.C. ... Corporation (NASDAQ: UTHR ) announced today that ... before the market opens on Thursday, July 27, 2017. ... host a teleconference on Thursday, July 27, 2017, at ... dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  A rebroadcast ...
(Date:7/21/2017)... , July 21, 2017 Did you know that ... in 2016? Or that combined spending on brand medicines, generics and ... spending, with brands accounting for just half of this (7 percent)? ... two thirds of the world,s venture capital investments in high-growth biopharmaceutical ... ...
Breaking Medicine Technology: