Navigation Links
McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
Date:5/9/2010

A new study by researchers from McGill University and the University of British Columbia shows that mice, like humans, express pain through facial expressions.

McGill Psychology Prof. Jeffrey Mogil, UBC Psychology Prof. Kenneth Craig and their respective teams have discovered that when subjected to moderate pain stimuli, mice showed discomfort through facial expressions in the same way humans do. Their study, published online May 9 in the journal Nature Methods, also details the development of a Mouse Grimace Scale that could inform better treatments for humans and improve conditions for lab animals.

Because pain research relies heavily on rodent models, an accurate measurement of pain is paramount in understanding the most pervasive and important symptom of chronic pain, namely spontaneous pain, says Mogil.

"The Mouse Grimace Scale provides a measurement system that will both accelerate the development of new analgesics for humans, but also eliminate unnecessary suffering of laboratory mice in biomedical research," says Mogil. "There are also serious implications for the improvement of veterinary care more generally."

This is the first time researchers have successfully developed a scale to measure spontaneous responses in animals that resemble human responses to those same painful states.

Mogil, graduate student Dale Langford and colleagues in the Pain Genetics Lab at McGill analyzed images of mice before and during moderate pain stimuli for example, the injection of dilute inflammatory substances, as are commonly used around the world for testing pain sensitivity in rodents. The level of pain studied could be comparable, researchers said, to a headache or the pain associated with an inflamed and swollen finger easily treated by common analgesics like Aspirin or Tylenol.

Mogil then sent the images to Craig's lab at UBC, where facial pain coding experts used them to develop the scale. Craig's team proposed that five facial features be scored: orbital tightening (eye closing), nose and cheek bulges and ear and whisker positions according to the severity of the stimulus. Craig's laboratory had previously established studying facial expression as the standard for assessing pain in human infants and others with verbal communication limitations. This work is an example of successful "bedside-to-bench" translation, where a technique known to be relevant in our species is adapted for use in laboratory experiments.

Continuing experiments in the lab will investigate whether the scale works equally well in other species, whether analgesic drugs given to mice after surgical procedures work well at their commonly prescribed doses, and whether mice can respond to the facial pain cues of other mice.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related medicine news :

1. China facing public health crisis with projected increase in cardiovascular disease by 2030
2. 3M and Maryland Hospital Association's Quality Indicator Project Partner to Deliver Comprehensive Quality Solution
3. American Human Development Project Releases 'A Century Apart,' Revealing Alarming Disparities in Well-Being Among U.S. Racial and Ethnic Groups
4. Understanding causes of cancer and chronic disease: The Canadian Partnership for Tomorrow Project
5. Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape
6. HLP Integration and Pat Taylor and Associates, Inc. Announce a Project Alliance.
7. Yongye Nongfeng Signs Agreement to Secure Coal Resources Project in Inner Mongolia, PRC
8. CoreObjects Receives Project Management Institutes Excellence Award for Diabetes Contribution
9. 2010 UNICEF Tap Project Launches to Help Provide Safe Water to Children Worldwide
10. The NASCAR Foundation Announces The Big Five Projects for NASCAR Day
11. China VoIP & Digital Telecom Subsidiary, Beijing PowerUnique Technologies, Wins Virtualization Project Bid for Peking Universitys Third Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com recently ... of Eyeglasses . , Millions of individuals in the United States and Canada ... become a way to both correct vision and make a fashion statement. Even celebrities ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
Breaking Medicine Technology: