Navigation Links
McGill-UBC project creates mouse grimace scale to help identify pain in humans and animals
Date:5/9/2010

A new study by researchers from McGill University and the University of British Columbia shows that mice, like humans, express pain through facial expressions.

McGill Psychology Prof. Jeffrey Mogil, UBC Psychology Prof. Kenneth Craig and their respective teams have discovered that when subjected to moderate pain stimuli, mice showed discomfort through facial expressions in the same way humans do. Their study, published online May 9 in the journal Nature Methods, also details the development of a Mouse Grimace Scale that could inform better treatments for humans and improve conditions for lab animals.

Because pain research relies heavily on rodent models, an accurate measurement of pain is paramount in understanding the most pervasive and important symptom of chronic pain, namely spontaneous pain, says Mogil.

"The Mouse Grimace Scale provides a measurement system that will both accelerate the development of new analgesics for humans, but also eliminate unnecessary suffering of laboratory mice in biomedical research," says Mogil. "There are also serious implications for the improvement of veterinary care more generally."

This is the first time researchers have successfully developed a scale to measure spontaneous responses in animals that resemble human responses to those same painful states.

Mogil, graduate student Dale Langford and colleagues in the Pain Genetics Lab at McGill analyzed images of mice before and during moderate pain stimuli for example, the injection of dilute inflammatory substances, as are commonly used around the world for testing pain sensitivity in rodents. The level of pain studied could be comparable, researchers said, to a headache or the pain associated with an inflamed and swollen finger easily treated by common analgesics like Aspirin or Tylenol.

Mogil then sent the images to Craig's lab at UBC, where facial pain coding experts used them to develop the scale. Craig's team proposed that five facial features be scored: orbital tightening (eye closing), nose and cheek bulges and ear and whisker positions according to the severity of the stimulus. Craig's laboratory had previously established studying facial expression as the standard for assessing pain in human infants and others with verbal communication limitations. This work is an example of successful "bedside-to-bench" translation, where a technique known to be relevant in our species is adapted for use in laboratory experiments.

Continuing experiments in the lab will investigate whether the scale works equally well in other species, whether analgesic drugs given to mice after surgical procedures work well at their commonly prescribed doses, and whether mice can respond to the facial pain cues of other mice.


'/>"/>

Contact: Brian Lin
brian.lin@ubc.ca
604-822-2234
University of British Columbia
Source:Eurekalert

Related medicine news :

1. China facing public health crisis with projected increase in cardiovascular disease by 2030
2. 3M and Maryland Hospital Association's Quality Indicator Project Partner to Deliver Comprehensive Quality Solution
3. American Human Development Project Releases 'A Century Apart,' Revealing Alarming Disparities in Well-Being Among U.S. Racial and Ethnic Groups
4. Understanding causes of cancer and chronic disease: The Canadian Partnership for Tomorrow Project
5. Tishman Construction – World Leader in Sustainable Real Estate Development and Project Management – Exhibits at Abu Dhabi Cityscape
6. HLP Integration and Pat Taylor and Associates, Inc. Announce a Project Alliance.
7. Yongye Nongfeng Signs Agreement to Secure Coal Resources Project in Inner Mongolia, PRC
8. CoreObjects Receives Project Management Institutes Excellence Award for Diabetes Contribution
9. 2010 UNICEF Tap Project Launches to Help Provide Safe Water to Children Worldwide
10. The NASCAR Foundation Announces The Big Five Projects for NASCAR Day
11. China VoIP & Digital Telecom Subsidiary, Beijing PowerUnique Technologies, Wins Virtualization Project Bid for Peking Universitys Third Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured or ... West Penn Burn Center, part of the Allegheny Health Network, has partnered with ... the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” aims ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... ... February 12, 2016 , ... Vail knee specialist ... Leaders to Know in 2016 . The list consists of physicians establishing, leading and ... establish this list. , An Ambulatory Surgery Center, also known as an ASC, ...
(Date:2/12/2016)... PA (PRWEB) , ... February 12, 2016 , ... ... families of the Pittsburgh metro area, celebrates the beginning of the latest charity ... children develop social skills through art. Donations to this worthy cause are currently ...
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  Clinical Affairs leaders at pharmaceutical organizations are looking to either ... world. While some companies have conducted a significant number of clinical ... countries such as India and ... India are now requiring local clinical trials ... --> China and India ...
(Date:2/12/2016)... 12, 2016 Hypermarcas S.A. ("Hypermarcas") today ... offer (the "Tender Offer") to purchase any and ... amount of its 6.500% Senior Notes due 2021 ... USP5246AAF05) (the "Notes"). In connection with the Tender ... consents (the "Consents") of the holders of the ...
(Date:2/12/2016)... , Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces its ... to Okaloosa County Emergency Medical ... III ambulances and one LT2 van. Quality Emergency Vehicles in ... is responsible for the sale.  This is the latest in ... , Executive Vice President at Demers. --> Benoit ...
Breaking Medicine Technology: