Navigation Links
Mayo researchers provide atomic view of a histone chaperone
Date:3/1/2012

ROCHESTER, Minn. -- Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details. The findings are published in the journal Nature.

"The interactions we described are important for gene silencing and the DNA damage response," says senior author Georges Mer, Ph.D., a Mayo Clinic structural biologist. "This is exciting because our newfound knowledge will help us better understand these fundamental cellular processes."

In cells, our DNA is part of a structure called chromatin, comprised of proteins, the majority called histones, which are wrapped with the DNA. Associated with the histones is another group of proteins called histone chaperones, which promote the proper assembly or disassembly of the chromatin during the times our DNA is replicated or repaired when damaged. Their dysfunction has been linked to cancer, aging and other diseases.

The Discovery

Before this Mayo study, scientists knew that the histone chaperone Rtt106 helped in the deposition of histones -- specifically, a complex of histones H3 and H4 -- onto the replicating DNA. They did not understand how Rtt106 does this, given that it does not possess any of the known requirements. Histone H3 is in a modified form where one of its amino acids, lysine 56, is acetylated. Rtt106 does not seem to have an acetylated lysine reader domain.

Mayo researchers discovered two novel domains in Rtt106 that take on this role. One, termed the homodimerization domain, allows two molecules of Rtt106 to be linked so they can cooperate in binding histones H3 and H4. The other, called the double PH domain, is responsible for sensing the acetylated lysine of H3 and further reinforces the interaction. The combined actions of the two domains of Rtt106 enable it to perform the chaperoning function efficiently and properly. This is the first time anyone has described this mode of specific association between a histone chaperone and a modified histone complex.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Researchers find potential solution to melanomas resistance to vemurafenib
2. Kessler Foundation researchers present at DC Conference on Race, Ethnicity and Disabilities
3. Researchers Spot Genes Behind Macular Degeneration
4. 90 percent of firefighters exhibit symptoms of PTSD according to Ben-Gurion University researchers
5. New blood test for early cancer detection developed by Ben-Gurion University researchers
6. UC Davis MIND Institute researchers to present on autism at AAAS Annual Meeting in Vancouver
7. Nasty superbug is being studied by UB researchers
8. Researchers see differences in Autism brain development as early as 6 months
9. As diabetes emerges, researchers track diseases first steps
10. Salk researchers find new drug target for lung cancer
11. GW researchers reveal digital transcriptome of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... March 27, 2017 , ... Mt. ... launch of a months-long rebranding effort. This includes the introduction of new packaging ... discussions and market research, we learned that a simple, proactive approach to wellness ...
(Date:3/27/2017)... ... March 27, 2017 , ... The homeowner improvement and repair market is ... DIY and unlicensed contractors for renovations is also on the rise. Per a 2017 ... and of those, 42% failed to use a licensed contractor.(2) The risks associated with ...
(Date:3/25/2017)... Fort Atkinson, Wisconsin (PRWEB) , ... March 25, 2017 , ... Norland at Swissray ... and body composition analyzers for large subjects. The ELITE DXA has an active scan ... are too wide or long to fit in the scan area could not undergo an ...
(Date:3/24/2017)... York, NY (PRWEB) , ... March 24, 2017 ... ... global scale; from third world countries to hospitals in the United States, it’s ... a conversation on the current obstacles facing infection prevention and offers strategies for ...
(Date:3/24/2017)... San Antonio, TX (PRWEB) , ... March 24, 2017 , ... ... a new clinic which can be found at 9618 Huebner Road. The clinic is ... Thobaben, PT, OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to gain ... medical cannabis market will reach a value of USD 55.8 billion by ... the new growing industry. By the end of 2016, 28 states have ... cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports on four ... NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. (NYSE: EW), ... companies are part of the Healthcare sector, which gave back ... , 2017, with the NYSE Health Care Index declining 0.2% ... the S&P 500 were down about 0.4% as a group. ...
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
Breaking Medicine Technology: