Navigation Links
Mayo researchers provide atomic view of a histone chaperone
Date:3/1/2012

ROCHESTER, Minn. -- Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they have determined the 3-D structure and interactions of the histone chaperone Rtt106 down to the atomic details. The findings are published in the journal Nature.

"The interactions we described are important for gene silencing and the DNA damage response," says senior author Georges Mer, Ph.D., a Mayo Clinic structural biologist. "This is exciting because our newfound knowledge will help us better understand these fundamental cellular processes."

In cells, our DNA is part of a structure called chromatin, comprised of proteins, the majority called histones, which are wrapped with the DNA. Associated with the histones is another group of proteins called histone chaperones, which promote the proper assembly or disassembly of the chromatin during the times our DNA is replicated or repaired when damaged. Their dysfunction has been linked to cancer, aging and other diseases.

The Discovery

Before this Mayo study, scientists knew that the histone chaperone Rtt106 helped in the deposition of histones -- specifically, a complex of histones H3 and H4 -- onto the replicating DNA. They did not understand how Rtt106 does this, given that it does not possess any of the known requirements. Histone H3 is in a modified form where one of its amino acids, lysine 56, is acetylated. Rtt106 does not seem to have an acetylated lysine reader domain.

Mayo researchers discovered two novel domains in Rtt106 that take on this role. One, termed the homodimerization domain, allows two molecules of Rtt106 to be linked so they can cooperate in binding histones H3 and H4. The other, called the double PH domain, is responsible for sensing the acetylated lysine of H3 and further reinforces the inter
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers find potential solution to melanomas resistance to vemurafenib
2. Kessler Foundation researchers present at DC Conference on Race, Ethnicity and Disabilities
3. Researchers Spot Genes Behind Macular Degeneration
4. 90 percent of firefighters exhibit symptoms of PTSD according to Ben-Gurion University researchers
5. New blood test for early cancer detection developed by Ben-Gurion University researchers
6. UC Davis MIND Institute researchers to present on autism at AAAS Annual Meeting in Vancouver
7. Nasty superbug is being studied by UB researchers
8. Researchers see differences in Autism brain development as early as 6 months
9. As diabetes emerges, researchers track diseases first steps
10. Salk researchers find new drug target for lung cancer
11. GW researchers reveal digital transcriptome of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/21/2014)... BellasDress.com offers a wide range of women’s ... announces its BellasDress Christmas Sale , offering big ... , BellasDress is a famous online supplier of women’s ... a series of promotions. The dress experts of the ... “We are proud of offering high quality wedding dresses ...
(Date:12/21/2014)... AngelWeddingDress.com’s new collection of 2015 spring wedding dresses was ... designs in this collection, and all of them are ... promises to provide the most fashionable designs to ... fashion trends come and go. If ladies have any ... is ready to assist. , “These new models ...
(Date:12/21/2014)... Recently, one of the best prom dresses online shops ... introduced its new collection of 2015 prom dresses, and ... its prom dresses & other fashionable designs, up to ... quality dress products and great customer services to its ... the best prom dresses online shops around the world ...
(Date:12/21/2014)... 2014 Serious Buyer, Andrew Hawley from ... Morrison and the Doors International Ballroom at the Hilton ... be the only time that Morrison's mother would see ... 25, 1967. According to Hawley, “This would be the ... the Alexandria Roller Rink earlier that year and would ...
(Date:12/21/2014)... 21, 2014 SCI explores ... issues and systemic barriers for disabled athletes with ... Scheidies has a condition called juvenile macular degeneration, where ... how he adapted his athletic ambitions to his vision ... in triathlon to pioneer the way for other blind ...
Breaking Medicine News(10 mins):Health News:BellasDress.com Announces its BellasDress Christmas Sale 2Health News:2015 Spring Wedding Dresses From AngelWeddingDress Just Released 2Health News:New Prom Dresses From One Of The Best Prom Dresses Online Shops, LunaDress Prom Shop 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 3
... Commission has instituted a rule that doctors can no ... despite protests from lawyers and several doctors' groups. //Since ... misconduct by doctors and physician assistants and says that ... disciplinary action being taken. ,But the Commission ...
... out simultaneous raids on some government hospital doctors and ... Monday.// ,The raids were conducted in Chennai, Goa, ... the investigating agency said., ,The houses of Sudha ... Goel of Sucheta Kriplani Hospital here were searched, he ...
... is being tried in the Asia Pacific region, says drug ... in the US and further testing on a few hundred ... year, Dr. Hans L. Bock told the Straits Times. ... fast, given that this is an issue of major public ...
... at a leading National Health Services (NHS) trust will be moved ... to save tens of millions of pounds on hospital beds in ... 100 patients suffering from cancer or blood disorders at University College ... the Radisson Edwardian Grafton, a four-star hotel where rooms cost ?168 ...
... 350 crore to add 1,800 beds over the next 18 ... Group's total capacity would touch 7,200 beds, from the current ... 800 beds through management of hospitals and another 1,000 beds ... said here on the sidelines of India Health Summit organised ...
... U.S. Food Drug Administration (US FDA) has approved ... mg.// ,Cephalexin is used to treat many ... tonsillitis, ear infections, skin infections, and urinary tract ... obtaining the first product approval from the dedicated ...
Cached Medicine News:Health News:Hospital Cuts Costs By Moving Cancer Patients To Hotels 2
(Date:12/19/2014)... 2014  In the Friday, December 19 edition of ... Healthcare Information Technology (HIT) features Konica Minolta, the company announced today. ... with several leading healthcare organizations. In addition to ... markets, such as New York , ... , Minneapolis and San ...
(Date:12/19/2014)... Breckenridge Pharmaceutical, Inc. announced today that it ... Pvt. Ltd. ( Hyderabad, India ) under ... ANDAs.  Under the terms of the agreement, MSN will ... for the U.S. market, and Breckenridge will market and ... have agreed to develop an oral antibiotic with current ...
(Date:12/19/2014)... CARDIFF-BY-THE-SEA, Calif. , Dec. 19, 2014 /PRNewswire/ ...  Sorrento), an oncology company developing new treatments for ... privately-held immuno-oncology company developing proprietary Neukoplast ® ... announced today that the companies have entered into ... CAR-TNK™ (pronounced as "Car-Tank") immunotherapies for the treatment ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... FARMINGDALE, N.Y., March 1, 2011 Misonix, Inc. ... company that designs, manufactures, and markets innovative, therapeutic, ... neurosurgery, laparoscopic surgery, and other surgical and medical ... the ROTH Capital 23rd Annual Growth Stock Conference ...
... ERES ), a global technology-driven provider of clinical ... organizations, announced today that the Nasdaq Stock Market has ... will trade on the Nasdaq Global Select Market under ... advised to make note of this trading symbol change. ...
Cached Medicine Technology:ERT to Change Trading Symbol to "ERT" Effective March 7, 2011 to Properly Align Business Brand 2
This advanced digital monitor detects the appearance of an irregular heartbeat during measurement and gives a warning signal with your reading. An irregular heartbeat may cause or indicate cardiovasc...
... Through its unique and patented ... wires and trunk cables between patients ... monitors, allowing freedom of movement throughout ... technology, the LifeSync(R) System employs two-way ...
Inquire...
... STA Compact is ... access coagulation analyser for ... latex based .coagulation tests.The ... loading of primary tubes, ...
Medicine Products: