Navigation Links
Mayo researchers help discover genetic cause for primary biliary cirrhosis
Date:5/27/2009

ROCHESTER, Minn. -- Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause.

The finding, significant because it is a first step toward developing a targeted treatment and a cure, will be published in the June 11, 2009, issue of the New England Journal of Medicine.

"Now that we better understand the molecular basis of primary biliary cirrhosis, we can look for ways to specifically fix those elements," says Konstantinos Lazaridis, M.D., a Mayo Clinic hepatologist and a senior researcher in the study.

Currently, treatments for primary biliary cirrhosis can slow progression of the disease, which affects 1 in 2,500 Americans, 90 percent of them women. However, about half of patients do not respond to medical therapy. For some patients, a liver transplant cures the condition. But not all patients qualify for a transplant, and some transplant recipients experience a recurrence within five to 10 years.

The study was conducted at the University of Toronto using blood samples of patients collected at several medical centers in Canada and at Mayo Clinic's campus in Rochester, Minn., through its Primary Biliary Cirrhosis Genetic Epidemiology Research Resource. This resource comprises the biospecimens of hundreds of primary biliary cirrhosis patients and individuals who do not have the disease (controls) --matched for age, sex, race and state of residence. Mayo Clinic and the University of Toronto are among the largest treatment centers in North America for primary biliary cirrhosis.

The University of Texas MD Anderson Cancer Center in Houston provided historical controls and conducted the statistical analysis of the study.

The genetic link to pri
'/>"/>

Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... print component of Healthy Aging is distributed within today’s ... and an estimated readership of 420,000. The digital component ... and across a network of top news sites and ... campaign, click here . , The publication features ... The Social. Lainey Lui, Melissa Grelo, Traci Melchor, ...
(Date:12/20/2014)... 2014 Recently, VogueQueen.com, a leading wedding ... Big Sale Online for 2015. Great discounts are ... and old consumers can get a discount, up to ... company’s website before January 30, 2015. , VogueQueen.com has ... launched a prom dress promotion. Many customers worldwide like ...
(Date:12/20/2014)... 20, 2014 Angeldress.co.uk, the distinguished wedding ... for worldwide dress fans. The company has recently updated ... information. For the holiday season, Angeldress Blog ... wedding apparel. , Angeldress.co.uk prides itself in offering a ... of service. All the company’s outfits are very carefully ...
(Date:12/20/2014)... Atore, Inc, (San Francisco, CA CEO: Masashi ... focused portal on December 17th, 2014. , One ... US and Japan. , MERRY BIRTHDAY SITE : ... , MERRY BIRTHDAY MESSAGE is part of 5 future ... Features, Choose from thousands of stock photos to decorate ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer (called ... Christmas. In the promotion, all buyers worldwide can enjoy ... something special for the women who are looking for ... new collections of 2015 dresses have been unveiled recently. ... discounted prices. Visit our website now before they are ...
Breaking Medicine News(10 mins):Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:VogueQueen Big Sale Online For The Coming 2015 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2
... drugs used to fight infections represent a public health ... a review published in Clinical Infectious Diseases ... substantially alter clinical care and may lead to worse ... anti-infectives has slowed and the prevalence of multidrug-resistant pathogens ...
... Eighty-five percent of children,s learning is related to vision. ... never had an eye exam or any vision screening ... screenings they typically receive can detect only one or ... of Tennessee Space Institute in Tullahoma are working to ...
... , THURSDAY, Jan. 19 (HealthDay News) -- Many kidney ... a problem that can cause serious health problems and even ... their findings show that more needs to be done to ... the esophagus, stomach or first part of the intestine -- ...
... LONDON, ON When cancers become aggressive and spread ... about how to stop this development. A new imaging ... Chambers and John Lewis is providing insight into just ... deadly. Certain proteins, such as E-cadherin, are important ...
... While global attention to HIV/AIDS remains strong, a lack ... many developing nations, specifically in the Caribbean. By ... Institute of International Health is hoping to turn the tide ... for nearly 75 percent of the Caribbean,s AIDS cases. ...
... nights and cold weather have you feeling depressed, a new ... by Janis Anderson, PH.D., an associate psychologist in the Brigham ... (ages 21-64) men and women with Seasonal Affective Disorder (SAD) ... which one works better. For decades, researchers have known ...
Cached Medicine News:Health News:Anti-infective drug shortages pose threat to public health and patient care 2Health News:University of Tennessee researchers develop comprehensive, accessible vision testing device 2Health News:Kidney Failure Patients Prone to GI Tract Bleeding 2Health News:Lawson researchers engineer a switch to tame aggressive cancers 2Health News:Revamping HIV-prevention programs in the Caribbean 2
(Date:12/19/2014)... 18, 2014 Radiology information ... is used to store, manipulate, and distribute patient ... patient tracking and scheduling system, result reporting, and ... with HIS and other databases improves the hospital ... patient scheduling, patient list management, radiology department workflow ...
(Date:12/19/2014)... -- Decision Resources Group finds that the laparoscopic device market ... increase to a value of over $4.3 billion by ... the large direct energy device market. In particular, premium-priced ... to the advantages they offer and as new products ... Resources Group,s coverage of the U.S. laparoscopic device market: ...
(Date:12/19/2014)... Since last month,s FBI shutdown of online drug marketplace ... online black market for illegal drugs - Evolution Marketplace ... drugs and other illegal items.  New numbers from the ... lowering the numbers of drugs and illegal items available ... But some new sites that have emerged as potentially ...
Breaking Medicine Technology:The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
... results from a series of colchicine safety studies ... for colchicine when co-administered with certain commonly prescribed ... potentially life-threatening drug-drug interactions. The ... Basis of a Novel Colchicine Dose Reduction Algorithm ...
... Leading dental and pharmacy organizations are teaming up ... of dry mouth, a side effect commonly caused ... 500 medications can contribute to oral dryness, including ... blood pressure), decongestants, pain medications, diuretics and antidepressants. ...
Cached Medicine Technology:Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs 2Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs 3Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs 4Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs 5Dentists, Pharmacists Raise Awareness of Medication-Induced Dry Mouth 2Dentists, Pharmacists Raise Awareness of Medication-Induced Dry Mouth 3Dentists, Pharmacists Raise Awareness of Medication-Induced Dry Mouth 4Dentists, Pharmacists Raise Awareness of Medication-Induced Dry Mouth 5
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: