Navigation Links
Mayo researchers help discover genetic cause for primary biliary cirrhosis
Date:5/27/2009

ROCHESTER, Minn. -- Researchers have discovered a novel molecular path that predisposes patients to develop primary biliary cirrhosis, a disease that mainly affects women and slowly destroys their livers. Primary biliary cirrhosis has no known cause.

The finding, significant because it is a first step toward developing a targeted treatment and a cure, will be published in the June 11, 2009, issue of the New England Journal of Medicine.

"Now that we better understand the molecular basis of primary biliary cirrhosis, we can look for ways to specifically fix those elements," says Konstantinos Lazaridis, M.D., a Mayo Clinic hepatologist and a senior researcher in the study.

Currently, treatments for primary biliary cirrhosis can slow progression of the disease, which affects 1 in 2,500 Americans, 90 percent of them women. However, about half of patients do not respond to medical therapy. For some patients, a liver transplant cures the condition. But not all patients qualify for a transplant, and some transplant recipients experience a recurrence within five to 10 years.

The study was conducted at the University of Toronto using blood samples of patients collected at several medical centers in Canada and at Mayo Clinic's campus in Rochester, Minn., through its Primary Biliary Cirrhosis Genetic Epidemiology Research Resource. This resource comprises the biospecimens of hundreds of primary biliary cirrhosis patients and individuals who do not have the disease (controls) --matched for age, sex, race and state of residence. Mayo Clinic and the University of Toronto are among the largest treatment centers in North America for primary biliary cirrhosis.

The University of Texas MD Anderson Cancer Center in Houston provided historical controls and conducted the statistical analysis of the study.

The genetic link to pri
'/>"/>

Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Kicking blog MichaelHusted.com is featuring an interview ... role as a kicking coach, his kicking business, and on ... retired NFL kicker Michael Husted author of HustedKicking.com. , "Anthony ... one of the top pro free agent kickers out there,” ... at our 2014 Pro Camp and I was impressed with ...
(Date:9/2/2014)... 2014: The fact that mechanical heart valves increase risks ... from the ROPAC registry presented for the first time ... Professor Jolien W. Roos-Hesselink, co-chair with Professor Roger Hall ... 1.4% of pregnant women with a mechanical heart valve ... The Registry Of Pregnancy And Cardiac disease (ROPAC) is ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 “Harmonicas ... about a decade, primarily to help people with ... there are three developed systems,” says Dana Keller, ... substantively differ, the goals are much the same ... of some type of harmonica.” , The three ...
(Date:9/2/2014)... Fast hosting is a great choice for webmasters to ... hosting suppliers and announced that Arvixe, Bluehost and JustHost ... is hard to find a good fast hosting supplier. ... features, uptime, server speed and customer support. People can ... manager of Top10BestSEOHosting.com says. , Arvixe has a world-class ...
(Date:9/1/2014)... September 02, 2014 NAPW ... Healthcare, LLC as a 2014 Professional Woman of the ... for leadership in office management. As the largest, most-recognized ... virtually every industry and profession, the National Association of ... over 600,000 members and nearly 300 Local Chapters. , ...
Breaking Medicine News(10 mins):Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 2Health News:MichaelHusted.com Features Interview with Anthony Cantele of Cantele Kicking on His Role as a Kicking Coach and on Becoming a National Camp Series (NCS) Associate 3Health News:Mechanical heart valves increase pregnancy risk 2Health News:Mechanical heart valves increase pregnancy risk 3Health News:Harmonica Techs, Inventor of the Pulmonica Pulmonary Harmonica, Outlines New Uses for Harmonicas in Healthcare 2Health News:Harmonica Techs, Inventor of the Pulmonica Pulmonary Harmonica, Outlines New Uses for Harmonicas in Healthcare 3Health News:Top10BestSEOHosting.com Recommends Fast Web Hosting Suppliers 2Health News:National Association of Professional Women Announces Victoria Smith, Office Manager at Apex Healthcare, LLC, a 2014 Professional Woman of the Year 2
... ... ... ... ...
... ... relied on chest x-rays, stress tests, CAT scans and MRIs," said Dr. Myron Licht, ... in better understanding heart failure and cardiopulmonary disease because it provides objective information--primal physiology ... ...
... ... Cleveland medical malpractice attorney nets settlement for widow. , ... Cleveland, OH (PRWEB) February 23, 2010 -- Medical negligence ... reports that he and his firm have obtained a substantial monetary settlement on behalf of ...
... ... ... ... ...
... ... ... ... ...
... , ... ... ... ...
Cached Medicine News:Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 2Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 3Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 4Health News:BUAV Exposes Shocking Role Played by Laos in the International Trade in Primates for Research 5Health News:Apex Heart Care, First Arizona Clinic to Install Shape-HF; New Medical Device Measures Patient Physiology to Define Shortness of Breath 2Health News:Apex Heart Care, First Arizona Clinic to Install Shape-HF; New Medical Device Measures Patient Physiology to Define Shortness of Breath 3Health News:Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case 2Health News:Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case 3Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 2Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 3Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 4Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 5Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 6Health News:Pew Report: Louisiana Failing to Address Children's Dental Health Crisis 7Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 2Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 3Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 4Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 5Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 6Health News:Pew Report: New Jersey Failing to Address Children's Dental Health Crisis 7Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 2Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 3Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 4Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 5Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 6Health News:Pew Report: Florida Failing To Address Children's Dental Health Crisis 7
(Date:8/29/2014)... 29, 2014  United Therapeutics Corporation (NASDAQ: ... for the District of New Jersey ... case against Sandoz, Inc. regarding United Therapeutics, Remodulin ® ... ruled that U.S. Patent No. 6,765,117 is both valid ... marketing its generic product until the expiration of that ...
(Date:8/29/2014)... -- According to the new research ... Reagent, Primer, Probe, Custom Oligos), End-User (Research, Pharmaceutical ... NGS, DNA, RNAi) - Global Forecast to 2019" ... is expected to reach $1,712.1 Million by 2019 ... CAGR of 9.8% from 2014 to 2019.. ...
(Date:8/29/2014)... , Aug. 29, 2014  Unilife Corporation ("Unilife" or ... today that it intends to release its financial results ... June 30, 2014 after market trading ends on Tuesday, ... a conference call for 4:30 p.m. U.S. EDT on ... 6:30 a.m. AEST), to review the Company,s financial results, commercial ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that ... Health Care Conference on Wednesday, March 9, 2011 at 11:00 ... Interested parties may access a live webcast of the presentation ... It is recommended that listeners log on 15 ...
... A new ad campaign warns Mississippi legislators that ... prescription drug benefits and undermine the ability of pharmacy ... Mississippi families and businesses, said the Pharmaceutical Care Management ... put the State Board of Pharmacy (instead of the ...
Cached Medicine Technology:Onyx Pharmaceuticals to Present at the Cowen and Company 31st Annual Health Care Conference 2New Ad Campaign: Secret Provision Raises Taxes on Prescription Drug Benefits, Creates 'Conflict of Interest' 2
... Our thawing systems are automated, easy to ... from the outside environment by flexible snap-seal ... bacterial or viral contamination of the water. ... the systems can also accommodate bags of ...
Conventional Digitally-Controlled Water Baths...
... a flexible, self-expanding nitinol design intended to ... biliary system, is now available from Cook ... and Drug Administration. Incorporating the features that ... successful around the world, the Zilver 518 ...
... double spot test is a rapid, ... antibodies to T. cruzi in human ... samples. This test is intended primarily ... reactive samples should be confirmed by ...
Medicine Products: