Navigation Links
Mayo researchers discover mechanism of cell type-specific signaling in tumor development
Date:4/7/2009

ROCHESTER, Minn. Mayo Clinic researchers have discovered the mechanisms behind two key checkpoints in cell growth and development factors that may ultimately allow investigators to benchmark progression of tumor cells or stop them from further development. The findings appear in the current online issue of Developmental Cell.

The team led by Edward Leof, Ph.D., Mayo Clinic biochemist, demonstrated that p21-activated kinase 2 (PAK2), a key target for cancer growth and fibrotic tissue development, is activated in one type of tissue but not another. PAK2 is a downstream component of transforming growth factor beta (TGF-β) signaling in mesenchymal cells those that make up connective tissues in the body, as well as blood and lymphatic vessels. However, TGF-β is unable to activate PAK2 in epithelial cells those that make up external and internal linings, such as skin and the internal lining of many vessels.

"We decided to look at the factors that prevented PAK2 activation in epithelial cells," says Dr. Leof. "We found that a protein called Erbin, in cooperation with the NF2 tumor suppressor Merlin, controls the outcome."

Erbin, the researchers found, controls the tumor suppressor gene Merlin. When Merlin is absent or mutated, the result is schwannoma, a form of tumor involving Schwann cells which make up the myelin sheath that covers nerves. Merlin has also been shown to play a part in causing melanoma, mesothelioma and possibly colorectal cancers.

The researchers showed that in epithelial cells, which have high levels of Erbin, the formation of an Erbin/Merlin complex prevents PAK2 activity following growth factor stimulation. In the absence of Erbin (or Merlin), however, TGF-β stimulates PAK2 activity in some epithelia, overcoming a critical checkpoint in tumor progression.


'/>"/>
Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers Profile the Light Smoker
2. Alarming Rise in Autism Brings Hundreds of Parents, Researchers and Clinicians Together from Around the World to Atlanta April 17-19, 2009
3. PhRMA Honors Gardasil(r) Researchers With Discoverers Award
4. Researchers identify personality traits
5. Young eye researchers receive prestigious ARVO-AFER/Merck award
6. UT Southwestern researchers reveal how the brain processes important information
7. Researchers Test Lithium as Radiation Protector
8. UCI researchers find new way to fight cocaine addiction
9. Researchers question effectiveness of warning labels on over-the-counter drugs
10. Researchers Successfully Create Computer-Simulated Model for Evaluating Artificial Pancreas
11. Yale researchers discover mechanism for
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... 2014 SIMpalm, a leading mobile ... for iPhone for its client, which allows users to ... company, specialized in finding the right wine. At ... uses combined sensory, chemistry and wine information. All this ... “wine fingerprint.” Those wines that are close counterparts to ...
(Date:12/15/2014)... HealthDay Reporter FRIDAY, Dec. 12, ... the millions of American women who have migraine: The debilitating ... is no association between migraine and breast cancer risk," said ... Harvard Medical School. "There is no positive association, so there ... effect either." About 18 percent of American women and ...
(Date:12/15/2014)... SIMSBURY, CT (PRWEB) December 15, 2014 ... in the prestigious Women World Awards in the category ... of a gold award for her weekly career blog ... and practical advice to help professionals elevate their talent ... Her blog, named after her book Networking Ahead ...
(Date:12/15/2014)... CA (PRWEB) December 15, 2014 At ... the organizations AutismOne and Focus Autism ... enlighten attendees with research on the effects of toxins ... testing and intervention information. , Luminaries such as ... researchers from abroad with esteemed, credentialed colleagues of the ...
(Date:12/15/2014)... La Jolla, Calif. (PRWEB) December 15, 2014 ... Roasters made the Coffee Review “Top 30 Coffees of 2014.” ... number two, and their Guji Zone Ethiopia at number 10. ... list twice. , Coffee Review’s selection is ranked on ... The Sumatra Ulos Batak scored 96 out of 100, and ...
Breaking Medicine News(10 mins):Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Kathy McAfee, America’s Marketing Motivator, Wins Best Blog from Women World Awards 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3Health News:Bird Rock Coffee Roasters Ranks Second and Tenth in Coffee Review’s ‘Top 30 Coffees of 2014’ 2
... clinic, injecting an anesthetic at certain points can reduce the ... is being presented today at the annual meeting of the ... Diego, had found that about 16% of patients encounter a ... was explained that the biopsies are commonly performed on men ...
... a new type of insulin that is inhaled rather ... respiratory infection or are exposed to passive smoke.// ... for treatment of diabetes. It uses an inhaler developed ... for healthcare providers," Professor Philippe Camus of the University ...
... the Queen’s Balmoral Castle in Scotland kills cancer cells and ... the University of Maribor in Slovenia said that they placed ... them to those placed in normal lab water. ,They ... cancer cells 62.5 percent more quickly than normal water. In ...
... nurses will be given ?5,000 to retrain ... Scotland. Health minister Andy Kerr said that ... million over two years on this plan.// ... nurses who are trained outside Europe and ...
... that "any disorder in human faculties" increases dependence on ... Abdul Kalam Wednesday urged researchers to "direct their efforts ... affected by autism".// ,Equality can be generated ... skills and engaging the minds of affected children in ...
... Fatigue is so common among Americans that it almost ... says that although the underlying cause of persistent fatigue ... fatigue is imaginary.// ,According to Boosting Your Energy, ... emotionally. Still, most people—even those being treated for fatigue-producing ...
Cached Medicine News:Health News:Autistic Children Need Sense of Equality: A.P.J. Abdul Kalam 2Health News:Boosting Energy Naturally 2
(Date:12/15/2014)... -- Investor-Edge has initiated coverage on the following ... and Company (NYSE: LLY ), Nektar Therapeutics (NASDAQ: ... and Novartis AG (NYSE: NVS ). Free research ... . On Friday, December 12, 2014, the NASDAQ ... Average lost 1.79%, to finish the day at 17,280.83, and ...
(Date:12/15/2014)... , December 15, 2014 ... development company, is pleased to announce the grant of ... relating to its GPCR-focused drug discovery platform. ... strengthens the global patent estate covering Heptares, technologies and ... suite of patents recently granted by the US Patent ...
(Date:12/13/2014)... HUNTSVILLE, Ala. , Dec. 12, 2014 /PRNewswire-USNewswire/ ... has purchased the HiSeq X Ten sequencing system ... will enable HudsonAlpha to produce and analyze genomic ... purchase stems from the Institute,s commitment to research ... The HiSeq X Ten provides unprecedented capacity, ...
Breaking Medicine Technology:Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 2Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 3Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 4Analysts View on Pharma Equities - Zogenix, Eli Lilly, Nektar Therapeutics, Sanofi, and Novartis 5Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 2HudsonAlpha announces purchase of Illumina HiSeq X Ten sequencing system 3
... only test designed specifically for detecting ... pH. It includes a convenient pH ... range which is important in monitoring ... can now spend less time testing ...
... is recognized by medical professionals as the ... its accuracy, convenience and affordability. CLOtest was ... with Robin Warren, M.D. was the first ... and gastric ulcers. Today, CLOtest has become ...
Rapid Urease test for the presumptive identification of H. pylori in gastric mucosal biopsies...
... Rapid Test Strip and Device are rapid ... antibodies to Helicobacter pylori (H. pylori) in ... in the diagnosis of H. pylori infection ... older. They are intended for health professionals ...
Medicine Products: