Navigation Links
Mayo researchers: Genetic mutation linked to Parkinson's disease
Date:7/15/2011

JACKSONVILLE, Fla. Researchers have discovered a new gene mutation they say causes Parkinson's disease. The mutation was identified in a large Swiss family with Parkinson's disease, using advanced DNA sequencing technology.

The study, published today in the American Journal of Human Genetics, was led by neuroscientists at the Mayo Clinic campus in Florida and included collaborators from the U.S., Canada, Europe, United Kingdom, Asia and the Middle East.

"This finding provides an exciting new direction for Parkinson's disease research," says co-author Zbigniew Wszolek, M.D., a Mayo Clinic neuroscientist. "Every new gene we discover for Parkinson's disease opens up new ways to understand this complex disease, as well as potential ways of clinically managing it."

The team found that mutations in VPS35, a protein responsible for recycling other proteins within cells, caused Parkinson's disease in the Swiss family. Mutated VPS35 may impair the ability of a cell to recycle proteins as needed, which could lead to the kind of errant buildup of protein seen in some Parkinson's disease brains and in other diseases like Alzheimer's disease says co-author Owen Ross, Ph.D., a neuroscientist at Mayo Clinic in Florida. "In fact, expression of this gene has been shown to be reduced in Alzheimer's disease, and faulty recycling of proteins within cells has been linked to other neurodegenerative diseases," he says.

So far, mutations in six genes have been linked to familial forms of Parkinson's disease, with many mutations identified as a direct result of Mayo Clinic's
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wistar researchers: Direct proof of how T cells stay in standby mode
2. Researchers: Sexually active teens need confidential health care
3. Researchers: Elderly patients 4 times more likely to die from treatment complications
4. Researchers: Pay more attention to epilepsy
5. Ben-Gurion U. researchers: High resistance rates among acute otitis media pathogens in children
6. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
7. Epigenetic pathway and new drug show promise in reversing a hard-to-treat childhood cancer
8. Genetic study sheds new light on auto-immune arthritis
9. UCSF team describes genetic basis of rare human diseases
10. Wayne State University researcher argues that sex reduces genetic variation
11. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Stress comes in ... from everyday life changes can lead to very serious, life-altering events. Fortunately nature ... with stress. Herbal supplement manufacturer MediHerb has coupled therapeutic doses of ...
(Date:9/1/2015)... ... September 01, 2015 , ... Philanthropic giving in the U.S. has ... and needs. Money for Good 2015, released today by Camber Collective, goes to the ... potential to mobilize up to $22B in new philanthropic giving and shift $25B that’s ...
(Date:9/1/2015)... , ... September 01, 2015 ... ... better therapeutic options to efficiently cure and prevent different malignancies. Some options ... have different pathophysiological properties due to which distinctive approach is necessary for ...
(Date:9/1/2015)... Jose, CA (PRWEB) , ... September 01, 2015 ... ... cross-device computing and collaboration, announces Splashtop Business for Remote Support , a ... remote support solution. Unhappy with the escalating renewal prices and inadequate customer ...
(Date:9/1/2015)... ... September 01, 2015 , ... Plaza OBGYN ... MonaLisa Touch® , an innovative vaginal health laser procedure that prevents and ... hormone-free treatment for atrophic vaginitis, a condition that causes vaginal dryness, pelvic discomfort, ...
Breaking Medicine News(10 mins):Health News:MediHerb Launches New Herbal Supplement to Help with the Challenges of Everyday Life 2Health News:MediHerb Launches New Herbal Supplement to Help with the Challenges of Everyday Life 3Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 2Health News:Camber Collective Releases Money for Good 2015 - Revealing Root Causes to Why Charitable Giving Has Been Stuck at 2% GDP Since the 70s 3Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 2Health News:CD Antigen Cancer Market and Pipeline Landscape Examined in Comprehensive Kuick Research Report Published at MarketPublishers.com 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:Houston's Plaza OB/GYN Now Offering the MonaLisa Touch® 2Health News:Houston's Plaza OB/GYN Now Offering the MonaLisa Touch® 3
... A complex autoimmune disease, rheumatoid arthritis (RA) is characterized ... begins with hyperplasia//, or excessive increase in size and ... bone destruction, this abnormal tissue growth is resistant to ... of healthy new cells. ,Decoy receptor 3 ...
... vaccine, administered in childhood to guard against pneumonia, meningitis//, and ... to pneumonia. ,The Centers for Disease Control has ... get four doses of the vaccine when they turn two. ... missed out on the vaccine, should take the shot without ...
... you if you have cancer or are at high risk of ... appear? ,Research happening today at the University of Michigan ... New genetic markers and proteins are being discovered that can identify ... ,But what does this progress mean to the average ...
... Awareness Week (NAW) kicks off this year from ... the American Association// of Neurological Surgeons (AANS) in ... meet in the nation’s capital to further their ... pain, spine and peripheral nerves, pediatrics, stereotactic, trauma, ...
... new standards to assess nutrition in children could lead to ... eligible// for emergency feeding programs, warn researchers in this week’s ... the number of nutritional emergencies has risen over the last ... the 1980s to more than 30 per year since 2000. ...
... treatment developed by a pediatric orthopedic surgeon has shown ... The treatment for rigid flatfoot//, which once required extensive ... ,Congenital vertical talus (CVT), or "rocker-bottom flat ... Left untreated, the patient would walk on the inside ...
Cached Medicine News:Health News:A Newly Identified Immunosuppressive Protein in Rheumatoid Arthritis 2Health News:Can Science Stop Cancer Before It Starts? 2Health News:National Neurosurgery Awareness Week Kicks Off During Annual Meeting of the AANS 2Health News:New Standards Could Cut Number of Malnourished Children on Feeding Programs 2Health News:Foot Deformity Could Be Corrected With Minimal Surgery 2
(Date:9/1/2015)... Sept. 1, 2015  AccuTec Blades, Inc. today announced ... Blades division.  EPC announced in May 2015 its intent ... Verona, Virginia and Obregon, Mexico ... sale process. Rick Gagliano , ... Blades said, "Our new name, AccuTec Blades, reflects the ...
(Date:9/1/2015)... --NOWDiagnostics Inc., based in Springdale, Ark. , ... Canada , a move that brings the company ... have greater access to information concerning their health. ... blood-based rapid tests that allow health care providers to ... ailments and diseases. ZBx Corporation, a Toronto ...
(Date:9/1/2015)... DALLAS , Sept. 1, 2015 UT ... and distinguished faculty members joined U.S. Representatives ... in a roundtable discussion on the 21 st ... biomedical research currently being considered by the ... faculty – including National Academy of Sciences members, department ...
Breaking Medicine Technology:AccuTec Blades, Inc. Announces Acquisition of Industrial Blades Division from Edgewell Personal Care Company 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5
... Conn., May 15, 2012 /PRNewswire-iReach/ -- Global ... important Cambridge Healthtech Institute conferences: IMVACS – ... August 13 – 15, Cambridge, MA - The ... under one heading: the Seventh Annual Novel Vaccines, Design ...
... Labs, Inc. (OTCQB/OTCBB: GOVX), a biotechnology company that creates, ... results for the three months ended March 31, 2012 ... delighted with recent developments that have strengthened and advanced ... David Dodd. "Our Phase 1/2 therapeutic vaccine trial continues ...
Cached Medicine Technology:Attendees Save up to $350 on CHI Conferences This Summer by Registering Through Global Information 2GeoVax Labs Reports 2012 First Quarter Financial Results 2GeoVax Labs Reports 2012 First Quarter Financial Results 3GeoVax Labs Reports 2012 First Quarter Financial Results 4GeoVax Labs Reports 2012 First Quarter Financial Results 5GeoVax Labs Reports 2012 First Quarter Financial Results 6
Straight shafts with 0.12 mm teeth and tying platform. Serrated handle with polished finish....
Angled 45 degree shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Heavy curved shafts with 2 x 2 teeth and crisscross serrated 6 mm tying platform. Serrated handle with polished finish....
Straight shafts with 1 x 2 teeth and 6 mm tying platform. Wide serrated handle with polished finish....
Medicine Products: