Navigation Links
Mayo oral cancer study shows full tumor genome
Date:2/23/2010

ROCHESTER, Minn. -- Mayo Clinic researchers along with collaborators from Life Technologies are reporting on the application of a new approach for sequencing RNA to study cancer tumors. Their findings from a proof-of-principle study on oral carcinomas appear in the current issue of PLoS One, the online science journal.

VIDEO ALERT: Additional audio and video resources, including comments by Dr. Smith, are available on the Mayo Clinic News Blog

To explore the advantages of massively parallel sequencing of genomic transcripts (RNA), the researchers used a novel, strand-specific sequencing method using matched tumors and normal tissues of three patients with the specific cancer. They also analyzed the genomic DNA from one of the tumor-normal pairs which revealed numerous chromosomal regions of gain and loss in the tumor sample.

The key finding of this work was that alterations in gene expression which can arise from a variety of genomic alterations frequently are driven by losses or gains in large chromosomal regions during tumor development.

In addition to the specific tumor findings, this study also demonstrated the value of this RNA sequencing (RNA-Seq) method. It will allow researchers to measure strand-specific expression across the entire sample's transcriptome. This technology reveals far more detail about genome-wide transcription than traditional microarrays.

"This method allows us to investigate genetic changes at a level that we were never able to see before," says David Smith, Ph.D., Mayo Clinic genomics researcher and corresponding author of the study. "This provides us with much more information about alterations during cancer development that could reveal important therapeutic targets. We can more completely understand the relationship between an individual's genome and the alterations to that which result in disease.

This is a huge step in speed, detail and diagnostic power for the fi
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Demand For Mobile Prostate Cancer Brachytherapy Vendor Programs Continues Into 2010
2. Statins May Benefit Prostate Cancer Patients
3. Genetic Mutation Linked to Prostate Cancer in Blacks
4. Information Gap Could Delay Lung Cancer Therapy in Blacks
5. MRI: Non-invasive diagnostic tool for diagnosing testicular cancer
6. Testicular Cancer Survivors May Have Hormone Deficiency
7. New DNA technique leads to a breakthrough in child cancer research
8. How to make the best decisions when at high risk for breast or ovarian cancer
9. Two Surgical Methods Equally Successful for Prostate Cancer
10. Survey finds significant racial differences in lung cancer beliefs
11. Testosterone deficiency affects male cancer survivors quality of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... City, Florida (PRWEB) January 22, 2015 IsoComforter, ... cold therapy machine with patented IsoTube design to treat specific ... has introduced the most progressive and easy to use patented ... treat post-operative and sports related orthopedic and muscle injuries. ...
(Date:1/22/2015)... Payday lending practices in four southern states ... distress to the states that permit them, according to ... on Race and Wealth. , While they generate hundreds ... at the same time substantially depress economic activity, according ...
(Date:1/22/2015)... 2015 As interest in the value of ... momentum worldwide, Rev. Eric J. Hall , president and ... (HCCN), will be the keynote speaker on January 27 at ... health system. , The conference, “Hope and Resilience: Innovative and ...
(Date:1/22/2015)... has released a new blog post presenting a list of vehicles ... , Some types of vehicles cannot be covered under an ... post to see if their vehicle qualifies for auto insurance coverage. ... the cars that cannot be covered by a plan. Clients have ...
Breaking Medicine News(10 mins):Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... Board of Directors , , Expected ... N.J., March 18 eFoodSafety.com, Inc. (OTC Bulletin Board: ... portfolio of aesthetic, dermatology, environmental and nutraceutical products, today ... Inc. to Nuvilex, Inc. The Company is also announcing ...
... CHICAGO, March 18 International Components Corporation (ICC), ... portable rechargeable systems, today launched a new series ... The new 150-watt series, designed for both industrial ... converter efficiency of up to 94% and an ...
... Transplanted Into the Jaw to Generate Dense Bone Tissue ... Jason Morgan needs a dental implant to restore ... be difficult due to a lack of strong, healthy ... Southern California-based dentist and founder of Platinum Dental, will ...
... repercussion in the treatment of epilepsy has been ... Mintzer, M.D., assistant professor in the Department of ... Jefferson Medical College of Thomas Jefferson University. ... most commonly prescribed anti-seizure medications may lead to ...
... device,manufacturer Ziehm Imaging launched the new, compact Ziehm ... in Vienna. This agile and versatile,C-arm delivers excellent ... provides flexible image display options and exceptional flexibility ... designed to meet the needs,of pain management and ...
... of comprehensive medical record solutions for healthcare providers, ... Wednesday, March 25th at their headquarters in Paramus, ... will focus on the rollout of the new ... to promote the integration of electronic medical records ...
Cached Medicine News:Health News:eFoodSafety.com, Inc. Changes Name to Nuvilex, Inc., Reflecting New Strategic Direction of Company 2Health News:eFoodSafety.com, Inc. Changes Name to Nuvilex, Inc., Reflecting New Strategic Direction of Company 3Health News:eFoodSafety.com, Inc. Changes Name to Nuvilex, Inc., Reflecting New Strategic Direction of Company 4Health News:Convection Cooled 150-Watt Open Frame Power Supply Meets Medical and Industrial Safety Standards 2Health News:Southern California Dentist First on the West Coast to Perform Concentrated Stem Cell Transplant for Dental Implant Procedure 2Health News:Southern California Dentist First on the West Coast to Perform Concentrated Stem Cell Transplant for Dental Implant Procedure 3Health News:New research suggests common anti-seizure medications may increase risk of cardiovascular problems 2Health News:Ziehm Imaging Introduces Ziehm Solo C-arm, Featuring a Versatile set-up in the OR and Exceptional Image Quality 2Health News:Ziehm Imaging Introduces Ziehm Solo C-arm, Featuring a Versatile set-up in the OR and Exceptional Image Quality 3Health News:Microwize to Hold Free Stimulus Package Workshop for Medical Industry 2Health News:Microwize to Hold Free Stimulus Package Workshop for Medical Industry 3
(Date:1/23/2015)... Jan. 23, 2015  Mallinckrodt plc (NYSE: MNK ... approved a share repurchase program. The open-ended authorization permits ... Mallinckrodt plc ordinary shares. "Funding additional ... priorities as we continue to pursue a range of ...
(Date:1/23/2015)... BOSTON , January 23, 2015 ... company, is delighted to announce that the Malcolm Campbell ... Miles Congreve (Vice President of Chemistry), Fiona Marshall ... (Chief Executive Officer and co-founder) for the seminal contributions ...
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... Levels With Doses an Order of Magnitude Lower than ... , , BETHESDA, Md., June 24 Spherix ... diabetes therapy, and a provider of technical and regulatory ... today announced positive preliminary results from a Phase 2 ...
... comply with recent FDA guidance for earlier testing-- ... Covance Inc. today announced ... Food and Drug Administration (FDA) guidance on Metabolites in ... human absorption, metabolism and excretion (AME) testing in support ...
Cached Medicine Technology:Spherix Announces Positive Phase 2 Study Results 2Spherix Announces Positive Phase 2 Study Results 3Spherix Announces Positive Phase 2 Study Results 4Spherix Announces Positive Phase 2 Study Results 5Spherix Announces Positive Phase 2 Study Results 6Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies 2Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies 3
Micro Dissecting Curette, 5 1/2", Round....
26 cm - 10 1/4, 140 mm - 5 1/2, bayonet-shaped, flexible, 90 angle, 4 mm...
14 cm, very delicate, round cupped jaws, straight jaws, 3.0 mm...
Toothed pituitary rongeur. Straight....
Medicine Products: