Navigation Links
Mayo-led study: Drug fails to reduce diarrhea in patients receiving radiation therapy
Date:9/24/2013

ROCHESTER, Minn. -- Sulfasalazine, a drug commonly prescribed to reduce diarrhea in patients with inflammatory bowel disease, does not reduce diarrhea in patients receiving radiation therapy for cancers in the pelvic area a Mayo Clinic-led study has found. The study also found that the medication may be associated with a higher risk of diarrhea than a placebo when used during radiation therapy to the pelvis. The results were presented today at the American Society of Radiation Oncology's (ASTRO's) 55th Annual Meeting in Atlanta.

"Patients receiving radiation therapy in the pelvic region can experience diarrhea which is a negative side effect of the therapy," says the study's lead author Robert Miller, M.D., a radiation oncologist at Mayo Clinic. Dr. Miller says that in previous trials sulfasalazine, which treats bowel inflammation, had been shown to decrease diarrhea in patients during pelvic radiation therapy.

Dr. Miller led a two-year, randomized, double-blind, placebo-controlled phase III clinical trial through the Alliance for Clinical Trials in Oncology to evaluate the effectiveness of sulfasalazine versus placebo in inflammation of the bowel during pelvic radiation therapy. The trial included 87 patients, with 78 patients evaluated for the primary endpoint, which was maximal severity of diarrhea up to six weeks after therapy, based on commonly accepted criteria. Patients enrolled in the study came from 24 institutions in the United States.

Patients received 1,000 milligrams of sulfasalazine or placebo orally, twice each day during radiation therapy and for four weeks after therapy. Patients completed bowel function questionnaires weekly during therapy, afterward for six weeks and at 12 and 24 months after therapy. Health care providers graded each patient on the maximum severity and the duration of maximum severity of diarrhea, rectal bleeding, abdominal cramping, constipation and tenesmus, the sensation of incomplete defecation.

Interim results from the study found a statistically significant excess of grade 3 diarrhea -- passing seven or more stools per day, in patients receiving sulfasalazine versus placebo. The study was halted in May 2013 when researchers determined that it was unlikely sulfasalazine would show benefit.

"While previous research had suggested benefit for sulfasalazine, we were very surprised to find that patients receiving sulfasalazine experienced worse diarrhea than those receiving placebo," Dr. Miller says. "We now know that sulfasalazine will not help patients receiving radiation therapy in the pelvic region avoid diarrhea as a side effect of the therapy." Dr. Miller says the study illustrates the need for large, phase III, randomized controlled trials to better understand which drugs and therapies can help mitigate the negative side effects for patients receiving radiation therapy.


'/>"/>

Contact: Joe Dangor
newsbureau@mayo.edu
504-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Cancer-causing gene alone doesnt trigger pancreatic cancer, Mayo-led study finds
2. Study: Memory problems, emotional stress result in early readmissions of heart patients
3. Study: Redefining the Criteria for ALK Positive Lung Cancer
4. Study: Redefining the criteria for ALK positive lung cancer
5. ACR, SBI on cancer study: More breast cancer screening needed in younger women
6. Study: Disease caused by repeat brain trauma in athletes may affect memory, mood, behavior
7. Study: Many evangelicals are ambivalent about homosexuality and civil unions for gays
8. Study: Heart pump with behind-the-ear power connector
9. Study: Centers throughout the brain work together to make reading possible
10. Study: Taxing sugary beverages not a clear cut strategy to reduce obesity
11. Study: Taxing Sugary Beverages Not a Clear Cut Strategy to Reduce Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... Cranbury, NJ (PRWEB) , ... February 23, 2017 ... ... Cure®, the pre-eminent publication and community for those in the fight against cancer, ... was important in their success. HRA will release top-line findings in a ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... Curemark, LLC ... safety and efficacy of CM-AT in children aged 3-8 with Autism, is now enrolling ... sites already enrolling children across the United States. , “There are currently no ...
(Date:2/22/2017)... NY (PRWEB) , ... February 22, 2017 , ... ... life and athletics. It’s enough to overwork even the sharpest brain. , Power ... offer peak healthy activity without over clocking the brain. Each capsule contains Cognizin® ...
(Date:2/22/2017)... ... February 22, 2017 , ... The National ... requirements effective with the April 2017 testing period. NACCM, a nonprofit organization, has ... Manager Certified (CMC) exam is periodically re-calibrated to ensure that newly certified professionals ...
(Date:2/22/2017)... ... February 22, 2017 , ... A cylindrical ... and sometimes harder to reach ones, according to the results of a clinical ... Conference in Houston by Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb. 23, 2017 MabVax Therapeutics ... drug development company, announces that it has received ... (FDA) authorizing the initiation a Phase I clinical ... pancreatic cancer. MVT-1075 ( 177 Lu-CHX-A?-DTPA-HuMab5B1) is the ... plans to initiate the phase I clinical trial ...
(Date:2/23/2017)... -- This report analyzes analyzes the worldwide markets for Wound Debridement ... for the US, Canada , ... Asia-Pacific , Latin America , and ... the period 2015 through 2022. Also, a six-year historic analysis ... derived from primary and secondary research. Company profiles are primarily ...
(Date:2/23/2017)... , Feb. 22, 2017 Summary ... non-hodgkin lymphoma partnering deals and agreements entered into ... the full report: http://www.reportlinker.com/p03605669-summary/view-report.html Description ... since 2010 report provides understanding and access to ... world,s leading healthcare companies. - Trends ...
Breaking Medicine Technology: