Navigation Links
Mayo-led research team develop agents that keep insulin working longer
Date:5/7/2010

keep the purse from opening up," Dr. Leissring says. "Ii1 is analogous to the magnetic latch, holding the two halves of IDE closed."

If IDE is inhibited, insulin remains in the body longer. Normally, about half of the insulin produced by the pancreas is immediately destroyed by the liver; no one knows why this occurs but it may be a way to regulate how much insulin enters the bloodstream, he says.

IDE inhibitors would slow the rate of this initial destruction. However, according to a surprising finding from the study, they would also help prevent degradation of insulin at the "destination" cells that are responsible for removing sugar from the bloodstream. "When insulin reaches cells, it is normally destroyed very rapidly by IDE. We show that when you stop that process with an IDE inhibitor, insulin stays around longer inside the cell, allowing the hormone to function more efficiently," Dr. Leissring says.

IDE inhibitors may also be beneficial for other diseases besides diabetes, the researchers suggest. "Insulin is involved in a surprisingly wide range of important processes, including memory and cognition, so IDE inhibitors may turn out to have multiple uses. They also will be very valuable as tools for basic research," says Dr. Leissring.


'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New research identifies modifiable risk factors for heart disease
2. Nuvo Research announces early redemption of 5% convertible debentures
3. Researcher to track spread of disease, malware and power outages
4. UCSF Researchers Identify Regulator of Human Sperm Cells
5. Octapharma Accepting Applications for Research Grants Through March 31
6. Valentine Tailgate Party for the Girls with Festive Ideas from Beauty Research
7. New Research Shows Genes of Pregnant Women and Their Fetuses Can Increase the Risk of Preterm Labor
8. University of Maryland chemist receives Astellas Award for blindness prevention research
9. Developing a cyberinfrastructure for comparative effectiveness in cancer research
10. Women should be allowed to eat, drink during labor: Queens University researcher
11. Parkinsons disease research uncovers social barrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... December 25, 2014 Today, Yunx.co.uk, a ... evening dresses and other special occasion outfits, unveils ... models are offered at discounted prices, up to 80% ... young ladies with their fashionable designs, gorgeous looks and ... exception. The business is devoted to designing and offering ...
(Date:12/24/2014)... HealthDay Reporter TUESDAY, Dec. 23, 2014 (HealthDay ... for one year will be allowed to donate blood in the ... 31-year ban on donations from men who have sex with men. ... to release a new draft guidance in early 2015 that would ... The FDA is changing its policy based on data from other ...
(Date:12/24/2014)... WEDNESDAY, Dec. 24, 2014 (HealthDay News) -- Adults ... higher risk of migraine headaches, suggests a study ... Neurology . "Childhood maltreatment can have long-lasting ... migraine in adulthood," study author Dawn Buse, director ... New York City, said in a journal news ...
(Date:12/24/2014)... Steven Reinberg HealthDay Reporter ... from the American Diabetes Association (ADA) call for giving the ... to help prevent heart disease. These new standards bring ... and American Heart Association, which also recommend giving low- or ... including people with diabetes. "We agree that the decision ...
(Date:12/24/2014)... Dr. Svetlana Gomer, MGS Tewksbury Dental, ... gathered with US Marines on November 14, 2014 for ... the Toys for Tots Literacy Program. This year’s ... books and audio books for the Toys for Tots ... Christmas. It represents another major strike in the battle ...
Breaking Medicine News(10 mins):Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 2Health News:FDA to Lift Ban on Blood Donations by Gay Men 3Health News:Abuse in Childhood Tied to Migraines in Adulthood 2Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 2Health News:Nearly All Diabetics Should Be on Cholesterol-Lowering Drugs: Experts 3Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3
... , RICHMOND, Calif., July 22 Transcept ... company focused on the development and commercialization of proprietary products ... announced today that Glenn A. Oclassen, President & Chief Executive ... Healthcare Conference in New York City on Wednesday, August 5, ...
... , , , ... Baxa Corporation announces the launch of updated, interactive functionality to the ... content features a unique interface that grants users a more in-depth view ... can zoom in to see high-resolution product photos and, on key products, ...
... , , , ... Nine hospital and health system clients of healthcare information technology ... ) have been named 2009 Most Wired award winners, according ... the July issue of Hospitals & Health Networks magazine. , ...
... , , WASHINGTON, July ... and public policy will look for ways to combat the ... a summit today co-convened by The AMERIGROUP Public Policy Institute ... Developing Families Center in Northeast, Washington, D.C., an integrated family ...
... , The National Comprehensive Cancer Network ... the Comparative Effectiveness of health care technologies in cancer care. This ... Effectiveness in Cancer Care to be held in December 2009 , ... The National Comprehensive Cancer Network (NCCN) ...
... , WALTHAM, Mass., July 22 ... on medical technology market intelligence, the recent Centers for ... hospital-acquired infections are resulting in adoption of antimicrobial-coated access ... MRG,s US Markets for Vascular Access Devices 2009 ...
Cached Medicine News:Health News:Transcept Pharmaceuticals to Present at BMO Capital Markets Healthcare Conference on August 5, 2009 2Health News:Transcept Pharmaceuticals to Present at BMO Capital Markets Healthcare Conference on August 5, 2009 3Health News:Transcept Pharmaceuticals to Present at BMO Capital Markets Healthcare Conference on August 5, 2009 4Health News:Baxa Launches Enhanced Online Product Content 2Health News:Nine CareTech Solutions Client-Hospitals Named 2009 Most Wired Winners 2Health News:Nine CareTech Solutions Client-Hospitals Named 2009 Most Wired Winners 3Health News:Nine CareTech Solutions Client-Hospitals Named 2009 Most Wired Winners 4Health News:AMERIGROUP Public Policy Institute, Black Leadership Forum, Inc. Convene Summit to Examine Preterm Birth Policy Solutions 2Health News:AMERIGROUP Public Policy Institute, Black Leadership Forum, Inc. Convene Summit to Examine Preterm Birth Policy Solutions 3Health News:NCCN Will Convene National Policy Summit on Comparative Effectiveness in Cancer Care 2Health News:NCCN Will Convene National Policy Summit on Comparative Effectiveness in Cancer Care 3Health News:Following CMS Cuts to Reimbursement for Medical Errors, New Devices Aimed at Reducing Nosocomial Infections Emerge 2Health News:Following CMS Cuts to Reimbursement for Medical Errors, New Devices Aimed at Reducing Nosocomial Infections Emerge 3
(Date:12/24/2014)... Mich. , Dec. 24, 2014  Diplomat Pharmacy, ... independent specialty pharmacy, is proud to announce Jennifer ... quality at Diplomat, will take office as the president ... The formal induction ceremony will take place Feb. 28, ... will be held at the Renaissance Center in ...
(Date:12/24/2014)... YORK and LONDON , ... global orthopedic industry are expected to grow at an ... in terms of value and volume. Hip, knee and ... developed world while in emerging economies they have a ... rates are challenging the use of composites. Non-metallic orthopedic ...
(Date:12/24/2014)... Dec. 23, 2014 Echo Therapeutics, Inc. ... company focused on skin permeation, continuous glucose monitoring ... W. Hollander has been appointed Chief Executive ... more than 20 years of experience in the ... most recently served as Vice President, Business Development, ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... 4, 2011 Cumberland Pharmaceuticals Inc. (Nasdaq: ... new senior credit agreement with Bank of America.  Pursuant to ... of credit to $10 million, which is expandable to $20 ... has been extended to December 2014. The new ...
... Mo., Aug. 4, 2011 Purdue Pharma, L.P., ... antiseptic to Children International , a U.S.-based ... world. To view the multimedia assets ... (Photo: http://photos.prnewswire.com/prnh/20110804/MM46982 ...
Cached Medicine Technology:Cumberland Pharmaceuticals Inks New Bank Financing Deal With Bank of America 2Purdue Pharmaceuticals Donates Medical Supplies to Protect Poor Children From Infection 2Purdue Pharmaceuticals Donates Medical Supplies to Protect Poor Children From Infection 3
0.5 mm wide x 1.5 mm long. Angled 20 degrees. Octagonal handle....
2 mm wide curved tip. Round handle....
8 mm downcutting Royce blade. Angled shaft. 60 mm from angle to tip....
3 mm disposable Lance blade. Can fit in to the N0521 Storz handle....
Medicine Products: