Navigation Links
Mayo collaboration finds source of breast drug side effect
Date:9/27/2010

ROCHESTER, Minn. -- Mayo Clinic researchers and their international colleagues have discovered genetic variants that lead to severe arthritis for a subset of women when taking aromatase inhibitors to treat their breast cancer. This serious side effect is so painful that many women halt their lifesaving medication. The findings appear today in the online issue of Journal of Clinical Oncology.

"Many women stop taking aromatase inhibitors due to the accompanying joint pain," says James Ingle, M.D., Mayo Clinic oncologist and senior author of the study. "We used the latest genetic technology in a very large group of women and discovered totally new clues to the cause of the main reason women stop this potentially lifesaving drug. Our findings open the door to finding ways to identify women who will develop these side effects and treat those who do, thus allowing more women to take this therapy and decrease their chances of breast cancer recurrence." Aromatase inhibitors are most often used as adjuvant therapy for postmenopausal women with early stage breast cancer.

How the Research Was Conducted

The researchers -- including investigators from the United States, Canada and Japan -- conducted a genome-wide association study to identify gene variants called single nucleotide polymorphisms (SNPs) that are associated with musculoskeletal pain. They selected patients who were enrolled in a prospective clinical trial, MA27, conducted by the NCIC Clinical Trials Group in Canada in collaboration with the NCI-sponsored North American Breast Cancer Groups comparing two aromatase inhibitor drugs. Two controls were matched with each patient and each patient who was selected experienced arthritis-like side effects within the first two years of treatment, or had already dropped out of the trial because of the pain. Researchers studied 293 separate cases, comparing them to 585 controls.

They found four likely SNPs on chromosome 14
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Alexza and Biovail Form Collaboration to Develop and Commercialize AZ-004 (Staccato(R) Loxapine) in North America
2. Web Content Management Enables Government Transparency, Participation, and Collaboration Online
3. MedPage Today(R) and Milwaukee Journal Sentinel Develop Journalism Content Collaboration for Enterprise Medical Reporting
4. NIH-FDA Joint Briefing on Regulatory Science Collaboration
5. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
6. Carefx Delivers Expert Insights on Health Data Sharing, Collaboration, Quality and Meaningful Use
7. Improved doctor-pharmacist collaboration needed: study
8. Tackling cardiovascular disease surge worldwide requires collaboration
9. French-Based Non-Profit AIDES is Starting a New Collaboration With Goodby, Silverstein & Partners
10. European collaboration seeks to create World Wide Web for robots
11. Johns Hopkins School of Medicine enters collaboration with New York Stem Cell Foundation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Glendale, AZ (PRWEB) January 22, 2015 Padre ... a long supporter of Pro Player Health Alliance ... with Padre Murphy's in getting everyone, including NFL greats, treated ... one of the leading groups supporting the cause in the ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... 2015 Carinsurancesavings.biz has released a new blog ... dismemberment insurance . , Purchasing an accidental death and ... advantageous. This type of rider provides benefits if the insured ... considered a lesser form of life insurance. , AD&D ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... annual revenues in the past three years. Today, the business ... , According to the sales manager of the company, this ... in 2015. This point can be reflected on the discounted ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... Ideal for ADA-Compliant Wall Fixtures; One-Fourth the Power of ... 25 OptoElectronix today announced a unique LED-based lighting ... SSL (solid state lighting) for commercial lighting fixtures. It ... bulb at just one-fourth the power and has a ...
... ... Interactive Multimedia category for its Orthopedic Patient Education Library. , ... Margate, FL (PRWEB) June 25, 2009 -- ... best of American business. All organizations operating in the U.S.A. were eligible to submit ...
... ... fiber syrup), Yum-Yum Zymes; and Brown Rice Protein in Chocolate, Vanilla and Berry flavors at ... Center/The Venetian Resort Hotel Las Vegas, July 9-11, 2009. , ... Los Angeles, CA (PRWEB) June 25, 2009 -- Jarrow Formulas®, ...
... Foundation for VoIP Communications at Additional Invacare Locations , ... Corp., a leading global manufacturer of wheelchairs and home ... manage its new European communications network. A fully managed ... to employees at the company,s 20 sales and production ...
... 25, 2009 -- Many parents worry about their child,s exposure ... wide variety of personal care products, children,s toys, and medical ... has been associated with negative changes in endocrine function. ... Journal of Pediatrics examines the possibility that in utero ...
... be faced with harsh decisions , , FOLSOM, Pa., ... Pennsylvania families should not have to worry about losing health ... -- and urged the General Assembly to adequately fund the ... , "The nation is experiencing one of the most ...
Cached Medicine News:Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 2Health News:OptoElectronix Offers Lighting Manufacturers A Unique Integrated LED Light Engine With 1,000 Lumens Light Output 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 2Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 3Health News:iHealthSpot, Inc Named Winner in the 2009 STEVIE' AWARDS (American Business Awards) 4Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 2Health News:Jarrow Formulas, Inc. to Unveil Children's Natural Health Products at Upcoming Natural MarketPlace 2009 Show in Las Vegas 3Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 2Health News:Verizon Private IP Quadruples Network Capacity for Invacare's European Operations 3Health News:Pennsylvania Governor Rendell Urges General Assembly to Support Children's Health Insurance Program 2
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ CM: ... CytoSorb® extracorporeal cytokine adsorber to reduce deadly inflammation ... receipt of $385,642, net of transaction costs, in ... Technology Business Tax Certificate Transfer Program sponsored by ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... BRUSSELS, Belgium, Sept. 15 ,Drais Pharmaceuticals, Inc. and ... a global agreement to develop and commercialize UNBS,5162, ... for cancer. UNBS 5162 was discovered by Unibioscreen ... United States in cancer patients with,advanced solid tumors ...
... Researchers at the Barbara,Ann Karmanos Cancer Institute ... a HER2 DNA vaccine that has shown to ... study was reported in the September 15 issue,of ... for Cancer,Research., ( http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELO ,GO), Wei-Zen ...
Cached Medicine Technology:Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 2Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer 3DNA Vaccine Developed at the Karmanos Cancer Institute Fights HER2-Positive Cancers 2
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
Medicine Products: