Mayo Genomic Discovery: Protecting Kidney Function During Hea... (pressure and BNP lowered it further. ...)

Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure

Date:6/15/2009

pressure and BNP lowered it further.

The Mayo investigators discovered an alternative splicing (AS) of BNP in messenger RNA (produced by the same gene). When they shortened the amino acid sequence of ASBNP for testing, they found that it had the same therapeutic benefits as BNP, but without the side effects to blood pressure. Positive impacts include increasing the kidney filtration rate, suppressing harmful protein production, and keeping water and salt flowing from the body. Potentially, this new drug would be given by IV to patients who are being treated in the hospital.

"There's an important reduction of kidney function every time one of these acute heart failure episodes happens," says Dr. Simari. "And by stopping one or more of those decrements, we hope there will be an overall improvement in long-term maintenance of kidney function."

Others on the team include Shuchong Pan, M.D., Ph.D.; Horng Chen, M.D.; Guido Boerrigter, M.D.; Candace Lee; Laurel Kleppe; Amir Lerman, M.D.; Margaret Redfield, M.D.; John Burnett, Jr., M.D.; all from Mayo Clinic, and Deborah Dickey, Ph.D.; Jennifer Hall, Ph.D.; and Lincoln Potter, Ph.D., all from the University of Minnesota. The research was funded by Mayo Clinic, the National Institutes of Health, and Anexon, Inc.

Mayo Clinic and five of the investigators associated with this research have a financial interest in the technology studied in the research. In accordance with the Bayh-Dole Act, that technology has been licensed to Anexon. Mayo Clinic and Drs. R. Simari and Dr. S. Pan have received royalties from the licensing of that technology of greater than the federal threshold for significant financial interes
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