Navigation Links
Mayo Clinic wins grant to gauge genetic risk of heart attacks, adverse drug reactions
Date:8/17/2011

ROCHESTER, Minn. -- Mayo Clinic researchers will receive more than $3 million in a four-year grant from the National Human Genome Research Institute to translate recent genomic discoveries into tools for individualized medicine. Recent advances in the genetics of heart and blood vessel diseases will be integrated into electronic medical records so doctors can more accurately determine patients' risk of heart attacks, blood vessel diseases and adverse reactions to heart medications.

"We will develop genetic risk scores for heart attack and adverse drug reactions as well as tools to communicate genomic risk to both patients and care providers," says Iftikhar Kullo, M.D., Mayo cardiologist and co-principal investigator on the award. "The goal is to accelerate the translation of recent advances in genetics and pharmacogenetics to the clinical practice, leveraging the electronic medical record."

The grant is part of the second phase of the Electronic Medical Records and Genomics Network, also known as eMERGE, a multisite effort to use data from a large number of medical records to enable genome-wide association studies. Mayo researchers will work with other eMERGE sites.

"This is an opportunity to expand the number and scope of conditions that we can look at across a larger consortium of practices," says Christopher G. Chute, M.D., Dr. P.H., Mayo Clinic biomedical informatics researcher and co-principal investigator. "We are beginning to integrate genomic information into electronic medical records with the goal of providing tools for physicians to meet the needs of the patient."

The first phase of eMERGE, which wrapped up earlier this year, demonstrated that information on disease characteristics in electronic medical records and patients' genetic information can be used in large genetic studies. So far, the network has identified genetic variants associated with dementia, cataracts, high-density lipoprotein-cholesterol, red blood cell traits, type 2 diabetes and cardiac conduction defects.

In phase II, investigators will identify genetic variants associated with 21 more diseases and medically relevant traits using genome-wide association studies across the entire eMERGE network. About 32,000 participants' DNA will be analyzed in each study. A genome-wide association study is a powerful technique in which researchers study hundreds of thousands of genetic variants in people with and without certain health conditions to identify genes that cause or contribute to diseases.

Mayo Clinic is one of seven institutions in the eMERGE network that received a grant. A total of $25 million was awarded.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. The West Clinic Joins Cancer Clinics of Excellence (CCE)
2. Stethoscope App gives iPhone New Clinical Skills
3. Mayo Clinic responsible for $22 billion in economic impact, including $9.6 billion in Minnesota
4. Sunquest Introduces Integrated Clinical Environment Physician Portal Solution in US
5. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
6. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
7. Sunquest Completes System-Wide Implementation at Cleveland Clinic Hospital Laboratories
8. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
9. NOVAVAX Presents Positive Clinical Results at The World Health Organization Conference, Geneva, Switzerland
10. UCLA Health System Presents: How to Successfully Implement a Clinical Portal
11. International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Networks Big Biz Show February 22, 2010 at 1:40 pm PST
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... , ... December 02, 2016 , ... U.S. Surgeon General, ... with Mediaplanet, Dr. Murthy explains how he was inspired to practice medicine at an ... that medicine is about more than making diagnoses and prescribing medicine,” he states. “It ...
(Date:12/2/2016)... ... ... More than half of American teens report losing their virginity before they ... child about sex related topics, less than 60 percent spoke about deeper themes like ... launch of its second edition of the “Sexual Wellness” campaign, aiming to address the ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... diagnostic imaging systems and the first company to offer robotic imaging to ... at their tradeshow booth # 941 for the American Association of Equine Practitioners ...
(Date:12/2/2016)... California (PRWEB) , ... December 02, 2016 , ... "Pro3rd ... allow FCPX editors to create versatile lower third titles with just a few clicks ... Pro3rd Accents Volume 2 includes 30 lower third animations. Choose from various styles with ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... ... Technologist/Clinical Laboratory Scientist & Author of Type 2 Diabetes: The Owner’s Manual, ... The Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec 2, 2016 Research and ... Database" newsletter to their offering. ... , , R&D ... Merie Publishing,s proprietary R&D Drug Pipeline Database provides 24/7 online access ... drugs on the market and on investigational drug candidates in research ...
(Date:12/2/2016)... -- bioLytical Laboratories, un líder mundial en test rápidos de enfermedades ... Test , a los miembros de la Kenya Pharmaceutical Association. ... ... HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la Clinton Health ...
(Date:12/2/2016)... GARDENS, N.Y. , Dec. 2, 2016  LifeVac, ... will be included in the Emergency Response Training and ... are very excited to have LifeVac become part of ... Lih , Founder and CEO of LifeVac. "Having an ... LifeVac safely and effectively will help leverage our efforts ...
Breaking Medicine Technology: