Navigation Links
Mayo Clinic wins grant to gauge genetic risk of heart attacks, adverse drug reactions
Date:8/17/2011

ROCHESTER, Minn. -- Mayo Clinic researchers will receive more than $3 million in a four-year grant from the National Human Genome Research Institute to translate recent genomic discoveries into tools for individualized medicine. Recent advances in the genetics of heart and blood vessel diseases will be integrated into electronic medical records so doctors can more accurately determine patients' risk of heart attacks, blood vessel diseases and adverse reactions to heart medications.

"We will develop genetic risk scores for heart attack and adverse drug reactions as well as tools to communicate genomic risk to both patients and care providers," says Iftikhar Kullo, M.D., Mayo cardiologist and co-principal investigator on the award. "The goal is to accelerate the translation of recent advances in genetics and pharmacogenetics to the clinical practice, leveraging the electronic medical record."

The grant is part of the second phase of the Electronic Medical Records and Genomics Network, also known as eMERGE, a multisite effort to use data from a large number of medical records to enable genome-wide association studies. Mayo researchers will work with other eMERGE sites.

"This is an opportunity to expand the number and scope of conditions that we can look at across a larger consortium of practices," says Christopher G. Chute, M.D., Dr. P.H., Mayo Clinic biomedical informatics researcher and co-principal investigator. "We are beginning to integrate genomic information into electronic medical records with the goal of providing tools for physicians to meet the needs of the patient."

The first phase of eMERGE, which wrapped up earlier this year, demonstrated that information on disease characteristics in electronic medical records and patients' genetic information can be used in large genetic studies. So far, the network has identified genetic variants associated with dementia, cataracts, high-density lipoprotein-cholesterol, red blood cell traits, type 2 diabetes and cardiac conduction defects.

In phase II, investigators will identify genetic variants associated with 21 more diseases and medically relevant traits using genome-wide association studies across the entire eMERGE network. About 32,000 participants' DNA will be analyzed in each study. A genome-wide association study is a powerful technique in which researchers study hundreds of thousands of genetic variants in people with and without certain health conditions to identify genes that cause or contribute to diseases.

Mayo Clinic is one of seven institutions in the eMERGE network that received a grant. A total of $25 million was awarded.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. The West Clinic Joins Cancer Clinics of Excellence (CCE)
2. Stethoscope App gives iPhone New Clinical Skills
3. Mayo Clinic responsible for $22 billion in economic impact, including $9.6 billion in Minnesota
4. Sunquest Introduces Integrated Clinical Environment Physician Portal Solution in US
5. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
6. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
7. Sunquest Completes System-Wide Implementation at Cleveland Clinic Hospital Laboratories
8. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
9. NOVAVAX Presents Positive Clinical Results at The World Health Organization Conference, Geneva, Switzerland
10. UCLA Health System Presents: How to Successfully Implement a Clinical Portal
11. International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Networks Big Biz Show February 22, 2010 at 1:40 pm PST
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... Canada (PRWEB) , ... February 13, 2016 , ... In ... foot forward. They’ll groom themselves to perfection, go out of their way to be ... date – just take a look at any online dating profile. , A ...
(Date:2/12/2016)... DC (PRWEB) , ... February ... ... Siemens Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop ... The partnership will recruit top students from U.S. universities who will draw ...
(Date:2/12/2016)... ... , ... As a former television executive, owner Tal Rabinowitz knows how stressful ... decompress, Rabinowitz found herself drawn to a casual meditation class while working at NBC ... implementing a 20-minute-per-day meditation practice with her team. After her tenure at NBC, she ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... , ... Erlanger Agency has announced a new partnership in its ongoing community ... on the fight against breast cancer, fundraising for a local woman named Carmen, who ... Carmen is a loving single mother of two boys who also serves as caregiver ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Governor Andrew M. Cuomo today announced a major expansion ... Western New York . This announcement, made ... includes a major expansion of Athenex,s North American headquarters ... , as well as the creation of a state-of-the-art, ... . The combined projects are expected to yield ...
(Date:2/11/2016)... Feb. 11, 2016 Potrero Medical, Inc., the developer ... announce the appointment of George M. Rapier, III , ... Antonio, TX , WellMed is one of the nation,s ... and HMO members in Texas and ... out of his own internal medicine practice, he has been ...
(Date:2/11/2016)... Ga. , Feb. 11, 2016  MiMedx Group, ... company utilizing human amniotic membrane and other birth tissues, ... platforms to develop and market advanced products and therapies, ... Capital Markets, 2016 Global Healthcare Conference in ... Chairman and CEO, Michael J. Senken , Chief ...
Breaking Medicine Technology: