Navigation Links
Mayo Clinic teams with glowing cats against AIDS, other diseases
Date:9/11/2011

ROCHESTER, Minn. -- Mayo Clinic researchers have developed a genome-based immunization strategy to fight feline AIDS and illuminate ways to combat human HIV/AIDS and other diseases. The goal is to create cats with intrinsic immunity to the feline AIDS virus. The findings -- called fascinating and landmark by one reviewer -- appear in the current online issue of Nature Methods.

Feline immunodeficiency virus (FIV) causes AIDS in cats as the human immunodeficiency virus (HIV) does in people: by depleting the body's infection-fighting T-cells. The feline and human versions of key proteins that potently defend mammals against virus invasion -- termed restriction factors -- are ineffective against FIV and HIV respectively. The Mayo team of physicians, virologists, veterinarians and gene therapy researchers, along with collaborators in Japan, sought to mimic the way evolution normally gives rise over vast time spans to protective protein versions. They devised a way to insert effective monkey versions of them into the cat genome.

"One of the best things about this biomedical research is that it is aimed at benefiting both human and feline health," says Eric Poeschla, M.D., Mayo molecular biologist and leader of the international study. "It can help cats as much as people."

Dr. Poeschla treats patients with HIV and researches how the virus replicates. HIV/AIDS has killed over 30 million people and left countless children orphaned, with no effective vaccine on the horizon. Less well known is that millions of cats also suffer and die from FIV/AIDS each year. Since the project concerns ways introduced genes can protect species against viruses, the knowledge and technology it produces might eventually assist conservation of wild feline species, all 36 of which are endangered.

The technique is called gamete-targeted lentiviral transgenesis -- essentially, inserting genes into feline oocytes (eggs) before sperm fertilization. Succeeding with it for the first time in a carnivore, the team inserted a gene for a rhesus macaque restriction factor known to block cell infection by FIV, as well as a jellyfish gene for tracking purposes. The latter makes the offspring cats glow green.

The macaque restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus's outer shield as it tries to invade a cell. The researchers know that works well in a culture dish and want to determine how it will work in vivo. This specific transgenesis (genome modification) approach will not be used directly for treating people with HIV or cats with FIV, but it will help medical and veterinary researchers understand how restriction factors can be used to advance gene therapy for AIDS caused by either virus.

The method for inserting genes into the feline genome is highly efficient, so that virtually all offspring have the genes. And the defense proteins are made throughout the cat's body. The cats with the protective genes are thriving and have produced kittens whose cells make the proteins, thus proving that the inserted genes remain active in successive generations.


'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert  

Related medicine news :

1. The West Clinic Joins Cancer Clinics of Excellence (CCE)
2. Stethoscope App gives iPhone New Clinical Skills
3. Mayo Clinic responsible for $22 billion in economic impact, including $9.6 billion in Minnesota
4. Sunquest Introduces Integrated Clinical Environment Physician Portal Solution in US
5. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
6. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
7. Sunquest Completes System-Wide Implementation at Cleveland Clinic Hospital Laboratories
8. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
9. NOVAVAX Presents Positive Clinical Results at The World Health Organization Conference, Geneva, Switzerland
10. UCLA Health System Presents: How to Successfully Implement a Clinical Portal
11. International Merchant Advisors CEO Mel Roseman to Discuss New Medical Marijuana Clinics Live on CBS Radio Networks Big Biz Show February 22, 2010 at 1:40 pm PST
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mayo Clinic teams with glowing cats against AIDS, other diseases
(Date:7/27/2017)... ... 2017 , ... Conventus, New Jersey’s premier professional liability insurer ... new educational series of webinars and podcasts to guide medical practices on understanding ... The first two episodes of the series, entitled “Pain Management and Opioids: New ...
(Date:7/27/2017)... Wayne, NJ (PRWEB) , ... July 27, 2017 ... ... C. Breiterman is now inviting new patients with sleep apnea in ... referral. Dental sleep medicine helps patients treat their sleep apnea with the use ...
(Date:7/27/2017)... , ... July 27, 2017 , ... For bicycling enthusiasts ... does challenge. The 24-hour race takes place against a backdrop of tree-lined hills at ... to run from July 28-30, Rad am Ring consists of some 73 curves, stretching ...
(Date:7/27/2017)... CA (PRWEB) , ... July 27, 2017 , ... ... the addition of a secure cloud-based polysomnography (PSG) distributed scoring solution to its ... accelerated diagnostics and sleep care management. The speed and functionality of scoring in ...
(Date:7/27/2017)... ... July 27, 2017 , ... GAFFEY ... internal promotion of Elrene Clinkscales to Vice President of Revenue Cycle Business Services ... reporting to Derek Morkel, chief executive officer (CEO). , Elrene has been with ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... Inc. ("Hill-Rom") (NYSE: HRC), today announced financial results for ... updated its financial outlook for fiscal 2017. ... quarter, Hill-Rom reported earnings of $0.09 per diluted share ... period. These results reflect after-tax special items, including a ... the non-cash write-down of assets associated with the planned ...
(Date:7/28/2017)... FLINT, Mich. , July 28, 2017 EnvoyHealth, ... (CMT) to pilot a program for CleverCap LITE, a ... CMT strives to deliver innovative health technology solutions ... adherence. CleverCap LITE ... The compact, high-tech bottle cover: ...
(Date:7/27/2017)... Holdings, Inc. (NYSE and SIX: ZBH) today reported financial results ... reported second quarter net sales of $1.954 billion, an ... an increase of 2.1% on a constant currency basis.  ... LDR Holding Corporation acquisition, second quarter 2017 revenues decreased ... on a constant currency basis. ...
Breaking Medicine Technology: