Navigation Links
Mayo Clinic researchers say breast cancer survival improves Herceptin used with chemotherapy
Date:12/12/2009

SAN ANTONIO Using Herceptin with chemotherapy, instead of after, clearly improves treatment of women with HER2+ breast cancer, and should be the new standard of care, says a Mayo Clinic researcher who led what is regarded to be a key clinical trial determining the best use of Herceptin.

Patients using Herceptin and chemotherapy at the same time had a relative 25 percent reduction in the risk of recurrence of cancer or death, compared with women who used Herceptin after chemotherapy, says Edith Perez, M.D., chair, North Central Cancer Treatment Group (NCCTG) Breast Committee and a breast cancer researcher at the Mayo Clinic campus in Jacksonville, Fla. She presented the findings of the study at the Cancer Therapy & Research Center-American Association for Cancer Research (CTRC-AACR) 2009 San Antonio Breast Cancer Symposium.

These findings may have global implications for women being treated for HER2+ breast cancer, which makes up 20 percent to 25 percent of all cases, Dr. Perez says.

In the United States, for example, Herceptin is approved for use on either a sequential or concurrent treatment schedule with adjuvant chemotherapy (that is, chemotherapy following surgery). In much of the rest of the world, Herceptin is used sequentially, she says.

"The results of this trial have been eagerly awaited in the U.S. and in many nations as this is the only trial developed to define the optimal way to incorporate Herceptin in the context of adjuvant chemotherapy," Dr. Perez says. "The goal was to decrease the risk of cancer recurrence, and we have shown that concurrent use is the best way to achieve that."

"This could mean that up to 10,000 women around the world each year may have a better outcome if Herceptin is used along with chemotherapy. Given that, I believe this study will lead to a global re-evaluation of how Herceptin is used," she says.

Every year, approximately 250,000 women worldwide are eligible to be treated with Herceptin for invasive HER2+ breast cancer, says Dr. Perez.

Some data on part of the study, the (NCCTG) clinical trial N9831, have been released before, such as in 2005 in the New England Journal of Medicine. But this is the first time that mature outcome information on patients given sequential vs. concurrent treatment is available. The trial enrolled women who had surgery to treat Stage I-III invasive HER2+ breast cancer.

The study is the only phase III randomized clinical trial to assess chemotherapy alone (Arm A) versus either sequential (Arm B) or concurrent (Arm C) incorporation of Herceptin in patients. Chemotherapy used in the study was doxorubicin and cyclophosphamide then paclitaxel, and was administered for approximately six months. Herceptin was given for 52 weeks.

Two different comparisons were made in the study. The first looked at outcomes in Arm A (1,087 women) compared to Arm B (1,097 women) and found that five-year disease-free survival (defined as no cancer recurrence) was increased from 72 percent (Arm A) to 80 percent (Arm B). Researchers also tabulated 222 events (cancer recurrence or death) in Arm A compared to 164 events in Arm B.

The second comparison looked at 954 women enrolled in Arm B with 949 women enrolled in Arm C. Researchers found that patients in Arm C fared the best overall. Their five-year disease-free-survival increased to 84 percent, compared to 80 percent in Arm B.

"The study demonstrated that adding Herceptin clearly improves disease-free survival, with improvement if given after chemotherapy, but even more improvement if started concurrent with taxane-based chemotherapy," Dr. Perez says. "So, our recommendation for practice and regulatory agencies around the world is that Herceptin be given concurrent with adjuvant chemotherapy."


'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Clinical trial advances new approach to re-sensitizing breast cancer
2. HealthWyse Clinical and Financial Point of Care Software Addresses OASIS-C Regulations and More
3. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
4. Macomb County Announces New Location for Four Upcoming H1N1 Clinics
5. Most Antidepressants Miss Key Target of Clinical Depression
6. Regenerus Life Enhancement Programme from The Diagnostic Clinic Will Take the Fear Out of Ageing
7. Quantros(TM) Unveils Clinical Cafe, Social Networking Website for Healthcare Professionals Focused on Safety, Quality and Compliance
8. Pharmacyclics, Inc. Reports Interim Safety and Clinical Data from a Phase I/II Clinical Trial of its Oral HDAC Inhibitor PCI-24781 in Lymphoma at the American Society of Hematology Annual Meeting
9. Free Health Clinic Event Is Not Just for the Sick
10. Childrens Hospitals and Clinics of Minnesota Receives National Recognition for Quality and Efficiency
11. Centegra H1N1 Vaccination Clinics Continue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... WASHINGTON D.C. (PRWEB) , ... July 25, 2017 ... ... therapists and their clients, today announced it will be exhibiting and providing demos ... Convention at the Walter E. Washington Convention Center in Washington D.C. from August ...
(Date:7/25/2017)... ... July 25, 2017 , ... USHEALTH Group, Inc. has ... prestigious CEO World Awards®. The coveted annual CEO World Awards program encompasses the ... studies, corporate social responsibility, and milestones from every major industry in the world. ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... SignatureCare ... scholarship will be awarded for the fall semester to a deserving student. Get ... Centers Spring 2017 scholarship was awarded to Mariana Castillo who is a nursing student ...
(Date:7/24/2017)... Peru (PRWEB) , ... July 24, 2017 , ... ... for $1,000 total in scholarship awards to be awarded annually to and divided ... demonstrate an interest in bringing awareness to Amazonian plant medicine. To apply for ...
(Date:7/24/2017)... , ... July 24, 2017 , ... ... two organizations that already work hand-in-hand on an Innovation Collaboration program, have signed ... access, quality, experience and cost of the care members and patients receive. The ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... -- Eli Lilly and Company (NYSE: LLY ) has ... pending patent litigation in the U.S. District Court for the ... Cialis ® (tadalafil) unit dose patent. This patent was ... of the agreement, Cialis exclusivity is now expected to end ... unit dose patent for Cialis is valid and infringed by ...
(Date:7/11/2017)... -- Dr. Echenberg, founder of Echenberg Institute, is announcing a new safe and ... painful intercourse and other painful pelvic pain conditions such as pelvic floor ... ... ... -based start-up company, VuVatech LLC, fills a void in the women,s ...
(Date:7/10/2017)...  The tenth annual BioPharm America™ will ... at the Sheraton Boston Hotel, September 26–27. The event ... decision makers and innovative biotech startup companies. The event ... two impactful days. BioPharm America is now part of ... opportunities with 4,500+ life science industry influencers participating in ...
Breaking Medicine Technology: