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Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
Date:7/1/2014

se new genes can be developed to treat this cancer."

This kidney cancer is one of the top 10 solid cancers in the U.S. Researchers expect 60,000 new cases to be diagnosed this year, with 13,000 deaths. While the prognosis for kidney cancer that has not spread is good, patients with advanced or metastatic cancer will develop drug resistance. Patients with untreated metastatic disease have a five-year overall survival rate of less than 10 percent.

The research team, which includes Mayo graduate student and lead author Christina von Roemeling, has already published several studies identifying some of the genes they discovered in the genetic analysis. In considering the importance of these discoveries to patients, they decided to publish all the genes at once in Oncotarget.

"We are releasing these discoveries to the scientific community so that a large effort can be mounted to find out more about these genes and how they can be effectively targeted," Dr. Copland says. "We owe patients speedy research that focuses on new treatments to save lives."

Targeted therapies used now to treat kidney cancer are often toxic, he adds.

"The study findings represent a very major advancement in therapeutic target identification for ccRCC and open new avenues for drug discovery and development. Novel therapeutic agents acting on these new targets should bring about a significant improvement in the prognosis of ccRCC patients," says co-author and Mayo oncologist Han Tun, M.D.

The researchers examined an equal number of samples (72) of normal kidney and kidney cancer tissues. They looked at over- and under-expression of RNA from the tissue, as well as protein production because genes express RNA to produce protein. They found almost 6,000 genes that fit that description. They isolated and tested 195 genes that are consistently elevated across patient sa
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Contact: Kevin Punsky
904-953-0746
Mayo Clinic
Source:Eurekalert

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