Navigation Links
Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
Date:7/1/2014

se new genes can be developed to treat this cancer."

This kidney cancer is one of the top 10 solid cancers in the U.S. Researchers expect 60,000 new cases to be diagnosed this year, with 13,000 deaths. While the prognosis for kidney cancer that has not spread is good, patients with advanced or metastatic cancer will develop drug resistance. Patients with untreated metastatic disease have a five-year overall survival rate of less than 10 percent.

The research team, which includes Mayo graduate student and lead author Christina von Roemeling, has already published several studies identifying some of the genes they discovered in the genetic analysis. In considering the importance of these discoveries to patients, they decided to publish all the genes at once in Oncotarget.

"We are releasing these discoveries to the scientific community so that a large effort can be mounted to find out more about these genes and how they can be effectively targeted," Dr. Copland says. "We owe patients speedy research that focuses on new treatments to save lives."

Targeted therapies used now to treat kidney cancer are often toxic, he adds.

"The study findings represent a very major advancement in therapeutic target identification for ccRCC and open new avenues for drug discovery and development. Novel therapeutic agents acting on these new targets should bring about a significant improvement in the prognosis of ccRCC patients," says co-author and Mayo oncologist Han Tun, M.D.

The researchers examined an equal number of samples (72) of normal kidney and kidney cancer tissues. They looked at over- and under-expression of RNA from the tissue, as well as protein production because genes express RNA to produce protein. They found almost 6,000 genes that fit that description. They isolated and tested 195 genes that are consistently elevated across patient sa
'/>"/>

Contact: Kevin Punsky
904-953-0746
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. First targeted nanomedicine to enter human clinical studies
3. Clinical insight improves treatment with new lung cancer drug
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Mayo Clinic launches whole genome breast cancer study
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Mayo Clinic breast cancer study finds new type of mutation
9. Kroenke honored for outstanding contributions in clinical research training
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Association for Psychological Science, SAGE launch Clinical Psychological Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... ... 2015 , ... A leader in Primary Care Continuing Medical Education (CME), ... Su Barnwell as its new Director of Program Management. , Su has over 16 ... worked for Primary Care Network (PCN) as the Director, Program Implementation as well as ...
(Date:8/5/2015)... ... 05, 2015 , ... As the nation’s premier nonprofit organization ... support in order to reduce the incidence of brain aneurysms and improve outcomes ... has awarded the most funding in the 20-year history of the organization. , ...
(Date:8/5/2015)... ... August 05, 2015 , ... The President of Wisdom Natural ... of this year’s 50 Most Influential Women in Arizona by AZ Business Magazine. ... long-standing dedication to the well-being of consumers through Wisdom Natural Brands’ groundbreaking products ...
(Date:8/4/2015)... ... ... review site BestMillionaireDatingSites.com recently refreshed its list of the top dating platforms for wealthy ... service in the segment. , A representative from the site said, “You certainly cannot ... right dating platform so that they can make the most of it and find ...
(Date:8/4/2015)... ... August 04, 2015 , ... How cool is it ... inspires you via geolocation? The new "Now" feature will soon allow you to do ... able to inspire each other using the now feature. , Users will soon get ...
Breaking Medicine News(10 mins):Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 2Health News:Leading Continuing Medical Education (CME) Provider, Continuing Education Company (CEC), hires expert Su Barnwell as Director of Program Management 3Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 2Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 3Health News:Brain Aneurysm Foundation Awards Largest Amount of Research Funding at 9th Annual Brain Aneurysm Foundation Research Grant Awards Symposium Sept 10th in Houston, Texas 4Health News:Carol May Named One of the Most Influential Woman in Arizona 2Health News:Carol May Named One of the Most Influential Woman in Arizona 3Health News:Carol May Named One of the Most Influential Woman in Arizona 4Health News:BestMillionaireDatingSites.com Publishes Reviews of the Best Dating Sites for Wealthy Singles 2Health News:Ahhaa App Soon to Release the "Now" Feature 2
... could offer new treatments for other autoimmune disorders, study ... believe they have finally answered a basic question about ... body does the wheat protein gluten enter one,s system? ... Gastroenterology identifies the CXCR3 receptor in the ...
... July 24 Tepha, Inc., a developer of,medical ... polymers, announced,today that it has appointed John Hartnett ... Chief Operating Officer. Mr. Hartnett joins Tepha,following an ... he,progressed from field sales, to marketing management, and, ...
... (Becton,Dickinson and Company) (NYSE: BDX ) today reported ... quarter ended June 30, 2008,representing an increase of 14.5 ... rate reflects the favorable impact on all segments,from foreign ... 7 percentage points of the increase in quarterly revenues., ...
... Cancellations and Higher Operating Costs to Affect ... ... 7, 2008, DENVER, July 24 Air Methods Corporation,(Nasdaq: ... an update on second quarter 2008 results., Based on preliminary ...
... alliance of animal,lovers is attacking one of America,s most ... America is struggling with a weight problem. About ... Unfortunately, our pets -- they really,do look like us ... Campaign to End Obesity, a public/private partnership that includes,Harvard ...
... for its module cleanrooms. The feature is a utility panel ... cleanroom appearance. , ... Burnsville, Minn. (PRWEB) July 24, ... systems, announced today that they are now offering a utility panel ...
Cached Medicine News:Health News:Intestinal Gluten Receptor Is Gateway for Celiac Disease 2Health News:Tepha Announces Appointment of John Hartnett as Executive Vice President and Chief Operating Officer 2Health News:BD Announces Results for Third Fiscal Quarter 2Health News:BD Announces Results for Third Fiscal Quarter 3Health News:BD Announces Results for Third Fiscal Quarter 4Health News:BD Announces Results for Third Fiscal Quarter 5Health News:BD Announces Results for Third Fiscal Quarter 6Health News:BD Announces Results for Third Fiscal Quarter 7Health News:BD Announces Results for Third Fiscal Quarter 8Health News:BD Announces Results for Third Fiscal Quarter 9Health News:BD Announces Results for Third Fiscal Quarter 10Health News:BD Announces Results for Third Fiscal Quarter 11Health News:BD Announces Results for Third Fiscal Quarter 12Health News:BD Announces Results for Third Fiscal Quarter 13Health News:BD Announces Results for Third Fiscal Quarter 14Health News:BD Announces Results for Third Fiscal Quarter 15Health News:Air Methods Provides 2nd Quarter Update and Date of Quarterly Conference Call 2Health News:Air Methods Provides 2nd Quarter Update and Date of Quarterly Conference Call 3Health News:Air Methods Provides 2nd Quarter Update and Date of Quarterly Conference Call 4Health News:PetFit Challenge Helps Keep Pets - and Pet Owners - Healthy 2Health News:Gerbig Engineering Announces Availability of Cleanroom Utility Panel 2
(Date:8/4/2015)... York , August 4, 2015 ... titled " Non-invasive Prenatal Testing (NIPT) Market (BambniTest, Harmony, ... Others) - Global Industry Analysis, Size, Volume, Share, Growth, ... According to a new market report published by Transparency ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ...
(Date:8/4/2015)... Aug. 4, 2015 BioElectronics Corporation (OTC ... Musculoskeletal Pain Therapy medical devices, announced today that ... ActiPatch 7-day trial device has been published in ... Management http://www.futuremedicine.com/doi/full/10.2217/PMT.15.35 .  More than 5,000 ... submitted an assessment.  Chronic pain ...
(Date:8/4/2015)... DUBLIN , Aug. 4, 2015 Research ... of the "Alcohol Ethoxylate Market by Application (Household ... Geographies Global Market Trends, Forecasts to 2019" report ... of alcohol ethoxylate was valued at $5,124.9 million in ... of about 3.5% from 2014 to 2019. The data ...
Breaking Medicine Technology:Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 2Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 3Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 4Non-invasive Prenatal Testing (NIPT) Market Expected to Reach USD 2.38 Billion in 2022: Transparency Market Research 5BioElectronics' Landmark 5,000+ Chronic Pain Patient Study Published in Pain Management Medical Journal 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 2Global Alcohol Ethoxylate Market 2015 - Market Trends, Forecasts to 2019 for the $5.1 Billion Industry 3
... Regenerate Skeletal Muscle More,Efficiently than Male Cells, PITTSBURGH, April ... have a greater ability to regenerate skeletal,muscle tissue than ... Pittsburgh of UPMC. , The study, which is being ... Cell Biology, is the first ever to report a ...
... 10, 2007 /PRNewswire-FirstCall/ -- Kosan,Biosciences Incorporated announced data ... pipeline, including its Hsp90,inhibitor, epothilone and nuclear export ... American Association for Cancer Research,(AACR), being held in ... on Kosan's programs are as follows. The,location for ...
Cached Medicine Technology:The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 2The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem,Cells Work Better 3Kosan Announces Data Presentations at Upcoming AACR Annual Meeting 2Kosan Announces Data Presentations at Upcoming AACR Annual Meeting 3
... Topical, Bactericide, Microbicide for professional degerming, ... in skin disinfectants combining quaternary and ... synergistic blend of emollients and surfactants. ... gram-positive organisms tested in 30 seconds. ...
Aplicare's disposable 1-ounce pouches are designed for individual application and are ideal for reducing waste. They are used in nursing homes, home healthcare settings, blood banks, laboratories, em...
... multi-purpose topical solution is for ... Prep Spray is labeled for ... of cross contamination. The controlled ... method to the final step ...
... two and four ounce bottles ... the needs of procedural kit ... itself has been custom molded ... the cap perfectly. This product ...
Medicine Products: