Navigation Links
Mayo Clinic researchers identify enzyme involved in deadly brain tumors
Date:1/17/2013

ROCHESTER, Minn. -- One of the most common types of brain tumors in adults, glioblastoma multiforme, is one of the most devastating. Even with recent advances in surgery, radiation and chemotherapy, the aggressive and invasive tumors become resistant to treatment, and median survival of patients is only about 15 months. In a study published in Neuro-Oncology, researchers at Mayo Clinic identify an important association between the naturally occurring enzyme Kallikrein 6, also known as KLK6, and the malignant tumors.

"Our study of Kallikrein 6 showed that higher levels of this enzyme in the tumor are negatively associated with patient survival, and that the enzyme functions by promoting the survival of tumor cells," says senior author Isobel Scarisbrick, Ph.D., of Mayo Clinic's Department of Physical Medicine and Rehabilitation.

The findings introduce a new avenue for potential treatment of deadly glioblastomas: targeting the function of KLK6. The tumor cells became more susceptible to treatment when researchers blocked the receptors where the KLK6 enzyme can dock and initiate the survival signal.

Researchers looked at 60 samples of grade IV astrocytomas -- also known at this stage as glioblastomas -- as well as less aggressive grade III astrocytomas. They found the highest levels of KLK6 were present in the most severe grade IV tumors. Looking at the tumor samples, researchers found higher levels of KLK6 associated with shorter patient survival. Those with the highest levels lived 276 days, and those with lower levels lived 408 days.

"This suggests that the level of KLK6 in the tumor provides a prognosticator of patient survival," Dr. Scarisbrick says.

The group also investigated the mechanism of the enzyme to determine whether it plays a significant role in tumor growth. Researchers also found glioblastoma cells treated in a petri dish with KLK6 become resistant to radiation and chemotherapy treatment. <
'/>"/>

Contact: Bryan Anderson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. First targeted nanomedicine to enter human clinical studies
3. Clinical insight improves treatment with new lung cancer drug
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Mayo Clinic launches whole genome breast cancer study
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Mayo Clinic breast cancer study finds new type of mutation
9. Kroenke honored for outstanding contributions in clinical research training
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Association for Psychological Science, SAGE launch Clinical Psychological Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... November 29, 2014 The holiday season is ... recently announced its new collection of fashionable party dresses. What’s ... off, on all these brand new outfits; the special offer ... is a renowned online supplier and it has received a ... new items are specially designed to flatter various body shapes; ...
(Date:11/28/2014)... 2014 Pathways Home Health & ... This national movement was created to encourage people to ... local charities and causes. This online event, celebrated ... kickoff of the holiday shopping season. #GivingTuesday is to ... Cyber Monday is to online commerce. , The goal ...
(Date:11/28/2014)... is always making changes to its infrastructure architecture as ... effective, and secure experience. Most recently, the company announced ... to setup local servers for each country or continent. ... the globe. , 2. The ability to setup a ... millions of users in one network. , 3. The ...
(Date:11/28/2014)... November 28, 2014 Junk-A-Car ( http://www.junkacar.com ... expanding their service offerings to help drivers, especially those ... and Washington, D.C. metropolitan areas deal with the especially ... a large part of the country. , With the ... in hundreds of totaled, crashed and junk ...
(Date:11/28/2014)... Novatus, a leading provider of contract ... provides customers with greater reporting capabilities, more searchable ... we continue to evolve and grow the Novatus ... improved performance in response to requests from our ... the enhancements that we have made to Advanced ...
Breaking Medicine News(10 mins):Health News:Trendy Party Dresses For The Coming Holiday Season From Balfleet.com 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 3Health News:Brosix Infrastructure Architecture Changes to Benefit Users 2Health News:Junk-A-Car Expanding Service to Assist U.S. Car Owners That May be Affected by Severe Winter Storms 2Health News:Novatus Releases v5.1 with New Advanced Reporting Capabilities 2
... Swedish medical university Karolinska Institutet have determined the first ... interaction between the mammalian egg coat and sperm. The ... glimpse into the molecular architecture of animal egg coats, ... medicine and the possibility of developing novel contraceptives. , ...
... skin, intestinal mucosa or blood, have a lifespan of only ... replenishment of specialized cells is indispensable. This is the task ... cells. , Stem cells have two main characteristics: ... cell types that make up their respective tissue a ...
... AARP CEO Bill Novelli today released the following statement in ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ... are in dire economic times that will only get worse ... immediate choice is between letting these corporations go under -- ...
... 4 Cardinal Health and the,Texas Hospital Association (THA) ... to safeguard patients and combat deadly health care associated,infections ... Texas Hospital Association and its marketing subsidiary, HealthShare,recently endorsed ... help combat HAIs, improve patient care and dramatically reduce,infection-related ...
... Getting back in the gym and,erasing years of ... amounts of,weight because your health depends on it is ... joining forces with NBC,s hit weight loss,program The ... of,their lives by creating a co-branded protein product, The ...
... Diagnostics, a segment of BD (Becton, Dickinson and Company) (NYSE: ... Food and Drug Administration (FDA) Premarket Approval (PMA) for the ... designed to enhance cervical cancer screening for cytology laboratories using ... squamous carcinoma, adenocarcinoma and their usual precursor conditions. ...
Cached Medicine News:Health News:Crystallography reveals the 3-D structure of mammalian sperm receptor 2Health News:Dormant stem cells for emergencies 2Health News:Dormant stem cells for emergencies 3Health News:AARP: Health Care and Pension Reform Critical to Economic Recovery 2Health News:AARP: Health Care and Pension Reform Critical to Economic Recovery 3Health News:Texas Hospital Association Endorses MedMined(TM) Services to Help Fight Hospital Acquired Infections 2Health News:Texas Hospital Association Endorses MedMined(TM) Services to Help Fight Hospital Acquired Infections 3Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 2Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 3Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 4Health News:BD Receives FDA Approval for the BD FocalPoint(TM) GS Imaging System to Enhance the Detection of Cervical Cancer 2
(Date:11/26/2014)... Nov. 26, 2014  Cohen, Placitella & Roth, ... investors who purchased Nymox Pharmaceutical Corporation ("Nymox" or ... period from January 31, 2011 through November 2, ... and certain of its officers and directors publically ... of Sections 10(b) and 20(a) of the Securities ...
(Date:11/26/2014)... 2014   Regulus Therapeutics Inc . (NASDAQ: ... and development of innovative medicines targeting microRNAs, today announced ... CEO of Regulus, will present a company overview at ... at the New York Palace Hotel on Wednesday, December ... be webcast at the time of the presentation and ...
(Date:11/26/2014)... -- Investor-Edge has initiated coverage on the following ... PLC (NASDAQ: HZNP ), Endocyte Inc. (NASDAQ: ... ), and Theravance Inc. (NASDAQ: THRX ). Free ... http://investor-edge.com/register . On Tuesday, November 25, 2014, the ... Industrial Average edged 0.02% lower, to finish the day at ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 2Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... UBM Canon Medical Device Media Group,s ... the " Technological Advances in Implantable Devices " virtual event ... 5 p.m. Eastern.  The event is dedicated to cutting-edge trends ... conference and trade show offers the opportunity to learn from ...
... N.J., Feb. 1, 2011 Soligenix, Inc. (OTC Bulletin ... a late-stage biopharmaceutical company, announced today that it has ... and Chief Medical Officer. Dr. Horgan is a board-certified ... experience in the care of patients with inflammatory bowel ...
Cached Medicine Technology:UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 2UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4
... a floor model centrifuge to do, but just ... PR-7000M delivers up to 50% more force in ... faster and more efficiently., Tremendous Capacity ... liters, PR-7000M accommodates 30 microplates, up to 408 ...
Inquire...
Inquire...
Inquire...
Medicine Products: