Navigation Links
Mayo Clinic researchers formulate treatment combination lethal to pancreatic cancer cells
Date:4/20/2009

DENVER - A combination of two targeted therapies packs a powerful punch to kill pancreatic cancer cells in the laboratory, Mayo Clinic cancer researchers report. With further testing of these drugs that are from classes of pharmaceuticals already used in patients, the Mayo research may lead to new treatment opportunities for patients with pancreatic cancer, which is extremely difficult to treat.

In a study being presented at the annual meeting of the American Association for Cancer Research, Mayo Clinic Cancer Center investigators found that rapamycin and panobinostat (also known as LBH589) act synergistically when used in combination, destroying up to 65 percent of cultured pancreatic tumor cells.

The finding is particularly significant, says the study's first author, Mamta Gupta, Ph.D., because the three cell lines studied were all resistant to the effects of chemotherapy - as are many pancreatic tumors - and because the drugs studied are already available for treatment of patients. Panobinostat is approved as therapy for cutaneous T cell lymphoma (CTCL), and rapamycin is best known as an immunosuppressant to help prevent rejection of transplanted organs.

"We need new therapies and strategies for the treatment of pancreatic cancer because these tumors are resistant to almost all known treatments," says Dr. Gupta, a research associate in the Division of Hematology. "No targeted treatment has shown much value to date."

Dr. Gupta studied the combination of agents in pancreatic cancer cells because her previous research at Mayo Clinic had shown that this combination worked well in laboratory tests of non-Hodgkin's lymphoma. A phase one clinical trial to test this combination in patients with lymphoma will open soon at Mayo Clinic under the direction of Thomas Witzig, M.D.

"While our pancreatic cancer cell line results look very promising, these are laboratory, not clinical, studies," she says. "We are preparing to t
'/>"/>

Contact: Karl Oestreich
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Shared Health(R) Adds Practice Management Tools to Clinical Xchange(TM) Platform
2. Poniard Announces Publication of Results of Picoplatin Phase 2 Study in Journal of Clinical Oncology
3. Medarex Announces Clinical Data for MDX-1401 in Hodgkins Lymphoma at Annual Meeting of the American Association for Cancer Research
4. Chiltern Acquires Brazil-Based Clinical Research Organization Vigiun
5. Childrens Hospitals and Clinics of Minnesota Launches Series of Events to Benefit Cardiac Care
6. US releases updated clinical guidelines for HIV-associated opportunistic infections
7. University of Ottawa Heart Institute is North Americas First Clinical Site for Ultra-sophisticated X-Ray
8. Medifocus Inc. Reports Improved Clinical Efficacy for its Phase II, Randomized Clinical Study for the Treatment of Early Stage Breast Cancer Tumors
9. Leading Clinical Technology Organization M2S Inc. Announces the Appointment of Jeffrey Yablon as Senior Vice President, Business Development
10. Telik Announces Preclinical Presentations at AACR Annual Meeting
11. Clinical Diagnostic Lab Testing Market to Grow Over 90% through 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 As a board-certified orthopedic ... new offering of platelet-rich plasma (PRP) and ... is known for its world-class care of injury-caused ... surgical experience lacking in many other physicians offering regenerative ... are utilized for pain management and rehabilitation. Dr. Meier ...
(Date:4/17/2015)... 17, 2015 Baptist Health and The ... a partnership agreement designed to transform oncology care in ... have agreed to create a joint cancer program to ... translational research. Baptist MD Anderson Cancer Center is anticipated ... single destination for highly coordinated, multidisciplinary cancer care for ...
(Date:4/17/2015)... 2015 Connie Casad, M.D., a well-known ... advocate with 30 years of practice experience in Dallas, ... level of service for her patients with the availability ... recommended wellness books with a brief synopsis on each ... her interest in providing this service, Dr. Casad said, ...
(Date:4/17/2015)... 2015 Oxytocin is a ... and thought to help mothers bond to their newborn, ... substantiate this, new studies performed, at NYU Langone Medical ... reported by Medical News Today on April 16, 2015, ... maternal social behavior. The study reveals that, when oxytocin ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Ticket Down is a ... their 2015 Summer Tour. , The life of last-minute show announcements ... the popular group perform during the early part of 2015, but ... Will Wait,” “Little Lion Man,” “The Cave,” and “Believe,” will perform ... on June 2 at MCU Park at Coney Island in Brooklyn, ...
Breaking Medicine News(10 mins):Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 2Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 3Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 2Health News:Baptist Health and MD Anderson Finalize Agreement to Transform Cancer Care in Region 3Health News:Connie Casad, M.D. Provides Patients Recommended List of Wellness Books on Website 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 2Health News:Oxytocin Now Found to Help Diet Doc Patients Whose Weight Has Gotten out of Control Due to Emotional Eating Disorders 3Health News:Mumford and Sons Tickets in Clarkston/Detroit, Raleigh, Columbia/Baltimore, Chicago, Mansfield/Boston, Brooklyn, Calgary and Edmonton Now On Sale 2
... to a new study it is observed that reducing blood ... half. It is already known that hypertension (high blood pressure) ... a study carried out by doctors in Dallas, the effect ... ,A group of patients with systolic hypertension - ...
... National Cancer Institute has announced the a new study ... 20 centers around the United States. The study is ... effective in uncovering lung cancer before symptoms start.// ... and there are currently 90 million current and former ...
... to a latest study it is shown that ... a part of their brain responsible for handling ... they often demonstrate// deficits in higher-order thinking abilities, ... response inhibition. These problems lead to the typical ...
... future, infra-red light may enable assessment of blood chemistry ... potential spin-offs for health on the ground.// One of ... Institute, is needle-free blood tests. The space researchers want ... For this purpose, they are looking at near infrared ...
... new study, young women with a self-attacking antibody are ... (aPL) fight a person's own body tissue. //Generally, antibodies ... chance of blood clots, which can lead to an ... researchers conducted a study to determine the connection of ...
... benefits of consuming soy protein has been less explored. According to ... you can use the high protein content of soy in your ... low in saturated fat and cholesterol. If one wants to reduce ... be a good notion to replace soy for some common animal ...
Cached Medicine News:
(Date:4/17/2015)...  Over the next five years, the marijuana industry in ... predicting that 14 more states will legalize recreational marijuana and ... for legal cannabis grew 74 percent in 2014 to $2.7 ... market could grow more than fourfold to $11 billion in ... on marijuana. Cannabiz Mobile Inc. (OTCBB: LGBI) is ...
(Date:4/17/2015)... Today, the Pharmaceutical Research and Manufacturers ... biopharmaceutical companies as "We Work For Health Champions" ... community service. Established in 2009, the ... by the biopharmaceutical industry to honor employees who ... have also shown an outstanding commitment to their ...
(Date:4/17/2015)...   IBA Molecular, a global leader in ... it has signed a definitive agreement to sell its ... to Illinois Health and Science (IHS). Under IHS ownership, IBAM ... headquartered in Dulles, Virginia , and ... product and footprint synergies. IBA Molecular is jointly owned ...
Breaking Medicine Technology:Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3Health Care System to Acquire IBA Molecular North America 2Health Care System to Acquire IBA Molecular North America 3
... Provider Network presented checks totaling $80,000 to the two ... the Strata Conference in Santa Clara, California. The global ... Once again, the team of "Market Makers" ... Players include David Vogel, CEO and Chief Scientist of ...
... Food and Drug Administration (FDA) has cleared InTone™, a ... "InTone is a true medical breakthrough, and welcome ... issues," said Herschel "Buzz" Peddicord, president & CEO of ... we believe we can effectively treat this condition in ...
Cached Medicine Technology:Heritage Provider Network Awards $80,000 to the Progress Prize Winners in the $3Million Heritage Health Prize Contest at the Strata Conference in Santa Clara, California 2Heritage Provider Network Awards $80,000 to the Progress Prize Winners in the $3Million Heritage Health Prize Contest at the Strata Conference in Santa Clara, California 3Medical Breakthrough for Incontinence From InControl Medical, LLC Cleared by FDA 2
The workhorse electric system....
... The BD Safety Knife with BD Xstar ... shield that protects the blade in prodedure ... is based on a grind-less process for ... yields outstanding sharpness and consistency. The ...
... Safety Knife with BD Xstar Blade includes ... protects the blade in prodedure and handling. ... on a grind-less process for manufacturing surgical ... sharpness and consistency. The arch style, ...
... The BD Safety Knife with BD ... retractable shield that protects the blade in ... technology is based on a grind-less process ... process yields outstanding sharpness and consistency. ...
Medicine Products: