Navigation Links
Mayo Clinic researchers find genetic secrets to common kidney cancer
Date:5/18/2010

unction and inhibition of adipogenesis. Its loss is known to be critical to development of breast cancer. These four genes are known to control hundreds of other genes.
  • That ccRCC cells behave like stem cells undifferentiated cells that have the ability to become any type of cell in the body. ccRCC, but not normal kidney cells, has the capacity to undergo development of fat-producing cells or bone-making cells, depending on which laboratory culture medium they are placed in.
  • A gene expression signature for a biological process called epithelial-mesenchymal transition (EMT), a characteristic feature of invasive cancer and cells undergoing proliferation. EMT may be important for kidney cancer development.
  • The stem cell-like properties found in ccRCC may explain why this cancer is so resistant to treatment, says Dr. Tun. But it also suggests that newer classes of drugs designed to target stem cells may offer a new alternative to treatment for this cancer, he says.

    Additionally, one of the study's biggest surprises is that immune genes are being expressed in ccRCC cells, which may be the reason why ccRCC is one of the few cancers that responds to immunotherapy, says Dr. Tun. One such gene, TLR2, can help control the chronic inflammation that is integral to the disease process. Down-regulating these immune genes may therefore be another good strategy.

    "Based on these findings, we propose a cancer model for the development of ccRCC," says Dr. Copland. "Developmentally, kidneys are mesenchymal in origin and develop by biological processes, which include mesenchymal epithelial transition (MET). In our model, normal renal epithelial cells experience loss of normal renal function (dedifferentiation) and EMT as well as preferential adipogenic differentiation.

    "We think that these processes turn normal kidney cells into cancer cells with stem cell-like qualities. Since our samples came from patients with early-stage c
    '/>"/>

    Contact: Kevin Punsky
    punsky.kevin@mayo.edu
    904-953-0746
    Mayo Clinic
    Source:Eurekalert

    Page: 1 2 3 4

    Related medicine news :

    1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
    2. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
    3. Clinical course of subepithelial lesions
    4. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
    5. Landmark Textbook Aims to Improve Clinician, Consumer Understanding of Lesbian Health
    6. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
    7. Chiropractors at Lyn Lake Chiropractic Clinic Provide Minneapolis, MN, Resource As Official MyFoxTwinCities.com ASK THE EXPERTS Sponsor
    8. Medpedia Launches New Clinical Trial Platform
    9. Macomb County Announces New Location for Four Upcoming H1N1 Clinics
    10. Most Antidepressants Miss Key Target of Clinical Depression
    11. Dr. David Williams Announces Launch of New Online Digestion Clinic
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:5/25/2015)... After the sensational buzz surrounding their past two ... Trivedi Master Wellness™ agrees to hold another ... “Consciousness is Power.” Presently, the Live-Streaming event is scheduled ... routinely allotted time from 10:00pm PST/1:00pm EST to 6:00pm ... to the public and accessible on the web through ...
    (Date:5/24/2015)... The Rolling Stones Zip Code summer stadium ... Petco Park. This iconic group is ready for their ... had a warmup show in Los Angeles at the Henry ... this beloved band not only played their Sticky Fingers album ... "Jumping Jack Flash," "Moonlight Mile" and "All Down the ...
    (Date:5/24/2015)... 24, 2015 EnviroLeather™ by LDI, ... Plus” – a classic, rugged leather grain with ... difficult stains, including ink, to be easily removed. ... suitable for corporate, healthcare, hospitality and education environments. ... EnviroLeather’s goal of developing products that are more ...
    (Date:5/24/2015)... May 24, 2015 ... CEO - The students were ... at the fourth annual A Day ... at Geneva National in Lake Geneva. ...     -Badger High School,         Jonathan Alfonso,         Bridget ...
    (Date:5/23/2015)... With the implementation of the Affordable ... increasingly difficult to provide their employees with a viable ... insurance for employees stand to face strict penalties. Never ... part of a business’s success or failure. In an ... USA Doctors has created a varying level of less ...
    Breaking Medicine News(10 mins):Health News:Hundreds of People Are Thrilled to Hear that Trivedi Master Wellness™ Promises to Hold Another Workshop in June 2015 2Health News:Hundreds of People Are Thrilled to Hear that Trivedi Master Wellness™ Promises to Hold Another Workshop in June 2015 3Health News:The Rolling Stones Tickets in San Diego, Orlando, Minneapolis, Dallas, Pittsburgh, Indianapolis, Atlanta, Detroit, Milwaukee, Kansas City, Columbus, Nashville & Raleigh 2Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 2Health News:Online USA Doctors Now Offers Cost-Saving Alternative Healthcare for Businesses 3
    ... Pa., April 15 Law Offices of Howard ... Inverness Medical,Innovations, Inc. ("Inverness Medical" or the "Company") ... savings plan (the "Plan"),imprudently invested in Inverness Medical ... duties to the Plan,s participants,in violation of the ...
    ... president and chief financial officer also appointed, PLANO, ... and chief executive officer of LifeCare Holdings, Inc., a,20-facility ... Texas.,Chief Financial Officer Phillip B. Douglas has been promoted ... chief accounting officer,will now serve as CFO., McAlister ...
    ... study reports that inner-city children with asthma may ... below current air quality standards. The study, available ... pollution levels on asthma symptoms and lung function ... National Institutes of Health (NIH) and the Environmental ...
    ... As taxpayers scramble to file on,time, hundreds ... Illinois Governor and,Congressional delegation to make wiser ... pours into Illinois annually from federal tax,sources ... restrict educators from mentioning contraceptives,or condoms except ...
    ... oral drug could benefit many with the autoimmune disease, researchers ... pill designed to reduce the number of attacks in people ... Italian researchers report. , The pill was effective in preventing ... the pill for three years, according to research that was ...
    ... Than One Week Away, AARP Members,Gather On Wednesday ... Philadelphia., PHILADELPHIA, April 15 With a ... the nation will be,watching Sen. Barack Obama and ... Party,s presidential nomination during a debate Wednesday,night in ...
    Cached Medicine News:Health News:LifeCare Holdings, Inc. Names McAlister Chairman and CEO 2Health News:Air pollution affects respiratory health in children with asthma 2Health News:Youth and Adults Throughout Illinois Urge Governor Blagojevich and Congress: Invest Our Tax Dollars Wisely 2Health News:Youth and Adults Throughout Illinois Urge Governor Blagojevich and Congress: Invest Our Tax Dollars Wisely 3Health News:Pill Reduces Relapses in MS Patients 2Health News:AARP to Host Discussion and Debate Watch Event 2Health News:AARP to Host Discussion and Debate Watch Event 3
    (Date:5/21/2015)... 2015  (MUSE Booth # 1510)What:Automating continuous vital ... is invaluable in any hospital setting, but particularly ... requirement and mainstream in healthcare, the integration of ... is gaining traction in MEDITECH facilities.During MUSE 2015 ... Project Manager & Clinical Analyst at McLaren Huron ...
    (Date:5/21/2015)... , 21. Mai 2015 /PRNewswire/ ... DPRX ), ein Unternehmen für Arzneimittel ... die Entwicklung und Vermarktung von Locilex® ... kündigte heute eine wissenschaftliche Posterpräsentation an, ... des Unternehmens vorstellt, OneStep-1 und OneStep-2, ...
    (Date:5/21/2015)... CHICAGO , May 21, 2015  Heidrick & ... executive search , leadership consulting and ... life sciences expertise among global practices announcing the addition ... Chicago office. Dietlin ... has worked globally and across R&D, Medical and Commercial ...
    Breaking Medicine Technology:Hospital Streamlines ICU Efficiency with Timely Data Integration 2Hospital Streamlines ICU Efficiency with Timely Data Integration 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7Heidrick Increases Healthcare and Life Sciences Expertise 2
    ... June 1 Shionogi Pharma, Inc., a U.S.-based group company ... two pivotal studies of the investigational new drug PSD502, a topical metered ...  These data were presented at the 2010 American Urological Association (AUA) Annual ... , , ...
    ... , June 1 OrthoDynamix announces a ... Biter is the first ever disposable biter used for ... every procedure affords the ultimate tissue interaction.  Moreover, the ... capsule structures.  Besides the jaw,s ability to bend 180 degrees, the ...
    Cached Medicine Technology:Pivotal Data for the Investigational Treatment PSD502 for Primary Premature Ejaculation in the United States to be Presented at Major Medical Meeting 2Pivotal Data for the Investigational Treatment PSD502 for Primary Premature Ejaculation in the United States to be Presented at Major Medical Meeting 3Pivotal Data for the Investigational Treatment PSD502 for Primary Premature Ejaculation in the United States to be Presented at Major Medical Meeting 4
    ... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
    ... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
    ... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
    ... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
    Medicine Products: