Navigation Links
Mayo Clinic researchers find genetic secrets to common kidney cancer
Date:5/18/2010

levels of mRNA for each gene in tissue samples taken from kidneys that were removed from 10 ccRCC patients. The kidneys were removed at the time of surgery and contained both normal tissue as well as tumor, so the scientists compared gene expression between the two to see what genes in the cancer were either over- or under-expressed, compared to normal cells.

Researchers found that 13,729 genes had altered expression in the cancer a figure Dr. Copland calls "just astounding, especially in trying to develop new treatments and in understanding the causes of kidney cancer." They used novel software that grouped these genes into meaningful biological pathways which helped them discover master genes. Each of these master genes regulates hundreds of "downstream" genes.

Researchers confirmed these gene expression findings in 20 kidneys removed from other ccRCC patients. Then, they validated gene expression at the protein level in kidneys taken from a different group of 50 ccRCC patients. To provide biological relevance, researchers then grew live normal kidney and ccRCC cells in a culture mediuam and conducted experiments.

Among the research findings are:

  • The top three biological pathways found included genes regulating normal kidney function and metabolic functions lost in ccRCC. Genes in immune pathways were also over-expressed.
  • A gene expression signature responsible for adipogenesis, which is the accumulation of globules of fat inside cells that is the reason for the "clear" appearance of ccRCC. Using a novel cell culture technique, they turned ccRCC cell lines into fat-acquiring "clear cells," mimicking what happens in patients. In patient-matched normal cells, fat is not produced.
  • The loss of four developmental transcriptional factor genes in ccRCC that are important for normal kidney development. One of these genes, GATA3, controls many genes through transcriptional regulation of cell growth, immune f
    '/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
2. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
3. Clinical course of subepithelial lesions
4. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
5. Landmark Textbook Aims to Improve Clinician, Consumer Understanding of Lesbian Health
6. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
7. Chiropractors at Lyn Lake Chiropractic Clinic Provide Minneapolis, MN, Resource As Official MyFoxTwinCities.com ASK THE EXPERTS Sponsor
8. Medpedia Launches New Clinical Trial Platform
9. Macomb County Announces New Location for Four Upcoming H1N1 Clinics
10. Most Antidepressants Miss Key Target of Clinical Depression
11. Dr. David Williams Announces Launch of New Online Digestion Clinic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... ... triggering cost increases for fully insured employer-sponsored health insurance plans, more employers are ... employees), according to data released from the 2014 United Benefit Advisors (UBA) Health ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... endpoint data collection, cloud analytics and workflow solutions today announced the complete ... Portugal, September 22-24, 2015. The esteemed faculty of worldwide pharmaceutical and industry ...
(Date:9/3/2015)... ... , ... AvePoint, the established leader in enabling enterprise collaboration across ... – AvePoint’s solution for facilitating two-way collaboration and external sharing without ever having to ... is the fifth consecutive year an AvePoint product has made the list. , The ...
(Date:9/3/2015)... ... September 03, 2015 , ... The new In-Office ... of Provo, Utah. The Clinicians Report is a leading information source to the ... throughout the U.S. Whiter Image's In-Office whitening kits were favorably validated for use ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... Local filmmakers ... April Hannah & Michael Habernig from Path 11 Productions have had great success in ... age podcast has featured Hay House authors, Teal Swan who is the well known ...
Breaking Medicine News(10 mins):Health News:Self-Funded Pharmacy Plans Becoming More Popular Among Large Employers 2Health News:Self-Funded Pharmacy Plans Becoming More Popular Among Large Employers 3Health News:Self-Funded Pharmacy Plans Becoming More Popular Among Large Employers 4Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 2Health News:ERT Announces Final Agenda, Faculty for European PRO / eCOA Congress 3Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 2Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 3Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 4Health News:Whiter Image Products Get Positive Rating From The Clinicians Report 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3
... may be able to help people// suffering from fibromyalgia. ... of Florida the cough medicine seemed to bring relief ... from fibromyalgia. ,Fibromyalgia syndrome occurs with extensive musculo-skeletal ... this diseases. More women than men report to be ...
... that asthmatic women have tendency of// irregular menstruation. ... severe stress, serious disease, anorexia nervosa, and drug addiction. ... women for 8 years to understand the possible link ... the research said that younger women with asthma and ...
... Scientists said that the problem of inability to read ... in visual processes as was thought in recent years. ... of perception than anything else. ,Dyslexia is one ... children, who have difficulty in verbal skills, abstract reasoning, ...
... researchers have established the association between adult urinary incontinence ... than 1000 Turkish women, the research says that the ... same for exhibiting lack of control in controlling urine ... may suffer from some faulty neural pathway that connects ...
... apnea syndrome affects a lot of people who are ... of having a difficult night, these people may have ... ,Obstructive sleep apnea syndrome (OSAS), also known as the ... problems, stroke, obesity, breathing problems, sexual dysfunction and clinical ...
... Women who had been diagnosed with breast cancer need to ... with lowering of levels of ovarian hormones and this could ... cancer patients who regularly exercised for about an hour daily. ... Health Study who were diagnosed with breast cancer of stages ...
Cached Medicine News:
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/hcb7bz/pharmaceutical ) has announced ... UK - November 16-18, 2015)" conference to their offering. ... including Columbia, Peru , Brazil ... Uruguay , Paraguay , Venezuela ... , Chile This seminar can be ...
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/cnq7tc/medical_device ) has ... Studies: Clinical Evidence (London, UK - November 10-11, ... This course has been designed specifically for ... required for medical devices and in-vitro diagnostic products. ... and the emphasis on high quality, appropriate clinical ...
(Date:9/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/r6wspz/drug_delivery_in ) ... report "Drug Delivery in Central Nervous System ... their offering. Advances in understanding ... opened new avenues and possibilities for improved drug ... systems, enzymes, and receptors that control the penetration ...
Breaking Medicine Technology:Pharmaceutical Regulatory Affairs in Latin America Seminar - London, UK - November 16-18, 2015 2Medical Device Studies: Clinical Evidence Course - London, UK - November 10-11, 2015 2Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies Report 2015-2024 2Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies Report 2015-2024 3
... Broadspire, a Crawford Company (NYSE: CRDA ; CRDB) ... provider, is proud to announce that Gary Anderberg, Ph.D., practice ... of Risk & Insurance magazine,s 2010 Risk Innovator ... a leader with Broadspire,s e-Triage system, which helps analyze claims ...
... Pa., Sept. 15 The GBS /CIDP ... symposium on Guillain-Barre Syndrome (GBS) and Chronic Inflammatory ... 5-7, 2010.  Over 400 medical professionals, current and former ... expected to attend the three-day event at the Dolce ...
Cached Medicine Technology:Broadspire’s Gary Anderberg Named a 2010 Risk Innovator 2Broadspire’s Gary Anderberg Named a 2010 Risk Innovator 3GBS/CIDP Foundation to Hold 11th International Symposium 2
... The Eppendorf Mastercycler Family offers fast temperature ... for optimal flexibility. Personal cards enable safe ... reliable transfer of individual protocols between different ... for PCR and come with a two-year ...
96 well thermocycler with unique High Temperature Range (HTR) Peltier technology for fastest available heating and cooling rates up to 4C/sec with High Pressure Lid for automated sealing of PCR plate...
... 40 or 96 temperature cyclers, the gradient block ... range of up to 14 or 22 across ... temperature difference of up to 2C between adjacent ... test up to 12 different annealing temperatures in ...
... performance, high sample throughput instrument at a highly ... Flexible block format, a newly designed flexible heated ... Includes a four year or 80,000 Cycle Warranty! ... connected and run through a PC using Gensoft, ...
Medicine Products: