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Mayo Clinic researchers find gene they believe is key to kidney cancer
Date:5/20/2010

ds TRIII on the cell membrane, TRIII's growth inhibitory activity is TGF- independent, another novel finding.

They found that TRIII was not expressed in patient ccRCC tissues that they examined; in the laboratory, when it was re-expressed in human ccRCC cell lines, the kidney cancer cells died. "We believe TRIII is a tumor suppressor which is lost in a number of cancers," says Dr. Copland. "In ccRCC, every patient tumor that we have examined has lost the expression of this receptor as well as GATA3."

"Interestingly, the TRIII gene is regulated, not by one, but two different promoters. Our team is the first to clone the human TRIII promoters which allowed us to delete regions and discern how TRIII expression is regulated," explains Dr. Cooper. They eventually located a region that led to the discovery that GATA3 positively regulates TRIII expression in normal renal cells. This is the first transcription factor discovered to positively regulate the human TRIII gene.

"Now that we understand why TRIII is not expressed in kidney cancer, we can potentially turn the gene back on by reactivating GATA3 using methyltransferase and HDAC inhibitors," Dr. Copland says.


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Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic
Source:Eurekalert

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