Navigation Links
Mayo Clinic researchers find gene they believe is key to kidney cancer
Date:5/20/2010

3 regulates the expression of genes that are critical to cancer control in the kidney, and silencing it appears to be very important to the growth of kidney cancer and probably to others tumors, as well," he says. "No one could have guessed that would be the case in kidney cancer. This is a completely novel finding."

Adds first author Simon Cooper, Ph.D., a molecular biologist at Mayo Clinic, "This research is particularly exciting because GATA3 may be a good therapeutic target. Two classes of drugs known as histone methyltransferase inhibitors and histone deacetylase inhibitors are designed to remove the brakes that cancer puts on key genes, like GATA3, that are silenced during cancer."

The researchers say that GATA3 is silenced through methylation of the GATA3 gene, a chemical modification that commonly occurs in cancer due to a widespread genetic instability that activates methyltransferases and histone deacetylases (HDACs). This process occurs when methyltransferase and HDAC enzymes work together to attach or remove chemical groups from genes, effectively silencing them. The drugs used in this study work together to reverse methylation and deacetylation.

The HDAC inhibitor used in this study is currently being examined in clinical trials for other cancers. It is similar to HDAC inhibitors that are already approved by the Food and Drug Administration for use in cutaneous T cell lymphoma. Dr. Cooper says that data from this study proves that these drugs synergize to restore GATA3 function, but they still need to be tested in kidney cancer animal models to provide a rationale for proceeding to a cancer clinical trial in kidney cancer.

This study results from a 2003 discovery by Dr. Copland and his team that the loss of TRIII plays a critical role in kidney cancer cell growth. TRIII appears to be a tumor suppressor gene that blocks tumor growth. Although it is well known that the ligand, transforming growth factor beta (TGF-) bin
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
2. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
3. Clinical course of subepithelial lesions
4. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
5. Landmark Textbook Aims to Improve Clinician, Consumer Understanding of Lesbian Health
6. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
7. Chiropractors at Lyn Lake Chiropractic Clinic Provide Minneapolis, MN, Resource As Official MyFoxTwinCities.com ASK THE EXPERTS Sponsor
8. Medpedia Launches New Clinical Trial Platform
9. Macomb County Announces New Location for Four Upcoming H1N1 Clinics
10. Most Antidepressants Miss Key Target of Clinical Depression
11. Dr. David Williams Announces Launch of New Online Digestion Clinic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Data Integrity Problems on the Rise: , ... Partners/Suppliers, **FDAnews Webinar**, May 19, 2015 — 1:30 p.m. ... integrity issues have become a common and ever increasing ... issues within manufacturing operations or partner networks can be ... remediating them can be even more difficult. , ...
(Date:4/27/2015)... Cannabix Technologies Inc. (CSE: BLO) (OTC ... Iannapollo has become an Advisor to Cannabix Technologies, developer ... and workplace testing. Mr. Iannapollo is an expert on ... experience in the oil and gas industry, working for ... employer, and DOT compliance policies and strategies. He also ...
(Date:4/27/2015)... The global coagulation analyzers market ... in developed countries; however, it is expected to ... China, India and Brazil in the next five ... driven by factors such as increasing adoption of ... high-throughput hemostasis analyzers, developments in high-sensitivity point-of-care coagulation ...
(Date:4/27/2015)... 2015 The Global Pharmaceutical Packaging Market ... CAGR of 5.9% during the period 2015 – 2019. ... materials healthcare packaging market, mainly due to their cost ... market is extremely fragmented with the presence of ... of the market with the rest being occupied by ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 On the ... the dramatic nighttime skyline of beautiful Los Angeles, CA, ... host, star of “The Real Housewives of Orange County” ... Durkin Entertainment’s EcoLuxe Lounge and the “Salute to the ... center for substance abuse founded by Wickstrom, Rossi felt ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 2Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 3Health News:FDAnews Announces — Data Integrity Problems on the Rise: Confronting Data Integrity Issues Within Your Operations or Your Partners/Suppliers Webinar, May 19, 2015 4Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 2Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 3Health News:Rocco Iannapollo becomes an Advisor to Cannabix Technologies 4Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 2Health News:Coagulation Analyzers Market Concluded to Reach $3.58 billion by 2019 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 2Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 4Health News:Per Wickstrom Shares His Vision of Choices Recovery with Reality TV Star Gretchen Christine Rossi 2
... are worried about whether sporadic outbreaks of bird flu could ... impact of the H5N1 bird flu infection has been minimal ... a million lives, worldwide. ,The bird flu virus ... it has not inherited genetic changes that would enable human ...
... the cards that will be a landmark on the EM ... project which will come up// in two phases that will ... cancer patients. Bangalore and Ahmedabad will follow suit with ... Foundation chairman, had a meeting with the chief minister to ...
... of the leading insomnia drug companies. But at present it is ... this October. There's a range of insomnia drugs on the market, ... for some of the people who depend on Ambien for a ... supply for the French pharmaceutical company of late. A string of ...
... division, Loyola University Health System, Maywood, Ill has noted that ... NCAA Tournament // on the television screens turns even the ... is important to prevent injuring oneself even as you enjoy ... especially painful and require months of rehabilitation, so it’s best ...
... claimed two more lives, as informed by regulators who issued ... combination from the market. The drug combination, also called Mifeprex ... in any of those cases//. ,The Food and Drug ... infection previously implicated in four deaths of women who had ...
... Health Service in Wales will end this financial year ?71m ... that confirmed by the National Health Service in Wales will ... also been confirmed by the assembly government. It is a ... budget for the Welsh NHS is around ?4.9bn. ...
Cached Medicine News:Health News:Ambien and the Other Insomnia Drugs 2
(Date:4/27/2015)... , April 27, 2015 ... completed filing of a Pre-Marketing Notification Application (510k) with ... BRH-A2 Wound Management System. BRH Medical expects feedback from ... the US market with BRH-A2 following FDA pre-market clearance. ... Motti Oderberg , CEO for BRH Medical, ...
(Date:4/27/2015)... , April 27, 2015 TWi Pharmaceuticals, ... into a Settlement Agreement with Takeda Pharmaceutical Company ... Inc., Takeda Pharmaceuticals America, Inc. (individually and collectively, ... litigation related to TWi,s generic dexlansoprazole delayed release ... 60 mg dosage strengths. An Abbreviated New Drug Application ...
(Date:4/24/2015)... NASHUA, New Hampshire , und ... 2015 (Stand Nr. 4410) iCAD, ... führender Anbieter von moderner Bildanalyse, Lösungen für ... Behandlung von Krebserkrankungen, hat heute die sofortige ... ® Electronic Brachytherapy (eBx ® ) ...
Breaking Medicine Technology:BRH Medical, Ltd., Announces Filing of a Pre-Market Submission with the US Food and Drug Administration (FDA) for the BRH-A2 Tissue Management System 2TWi Announces Settlement with Takeda on Dexilant(R) Litigation 2Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 2Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 3Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 4Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 5Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 6
... YORK, Jan. 20, 2011 Reportlinker.com announces that ... its catalogue: Hospital Radiography & ... This is the most comprehensive ... radiology modality types (General Radiology, Mammography, R&F, Angiography, ...
... 2011 CyberKnife Center of Miami ( www.cyberknifemiami.com ... FACRO, FASTRO, announces a presentation regarding CyberKnife Treatment ... Association of Neurosurgeon,s Annual Meeting, on January 28, ... http://photos.prnewswire.com/prnh/20110120/FL32893 ) The presentation is ...
Cached Medicine Technology:Reportlinker Adds Hospital Radiography & Fluoroscopy Census 2CyberKnife Center of Miami to Present at 38th Annual Caribbean Association of Neurosurgeon's Conference 2
This new dedicated VICTOR2 model is for fluorescence and luminescence measurements....
... VICTOR2 V measures ... polarization, luminescence, time-resolved ... absorbance. A red-sensitive ... assay. All technologies ...
... is the modular VICTOR2 ... high density TR-fluorometry, stacker ... The extra high density ... excitation beam for TRF ...
Flexible and sensitive fluorescence/luminescence microplate reader for endpoint and kinetic...
Medicine Products: