Navigation Links
Mayo Clinic researchers find gene they believe is key to kidney cancer
Date:5/20/2010

JACKSONVILLE, Fla. Researchers at Mayo Clinic's campus in Florida have discovered a key gene that, when turned off, promotes the development of common kidney cancer. Their findings suggest that a combination of agents now being tested in other cancers may turn the gene back on, providing a much-needed therapy for the difficult-to-treat cancer.

Clear cell renal cell carcinoma (ccRCC), the most common kind of kidney cancer, accounts for just 3 percent of all cancers in the United States, but is the sixth leading cause of cancer death. No current treatment has had a measurable effect on the spread of the cancer, oncologists say.

In the May 20, 2010 issue of Oncogene, researchers describe a gene called GATA3 that has been silenced in ccRCC and is a key gene also lost in breast cancer. GATA3 controls many genes and proteins that regulate cell growth, and one of them, a receptor known as the type III transforming growth factor- receptor (TRIII), is absent in a number of cancers.

According to the study's senior investigator, John Copland, Ph.D., a cancer biologist at the Mayo Clinic campus at Florida, these findings will surprise many in the cancer field. "Cancer researchers know that GATA3 is essential for immune T cell development and function," he says. "As well, very recent studies show that GATA3 is also critical to breast cancer development, where GATA3 expression is limited to mammary luminal epithelial cells. GATA3 is lost during breast cancer progression and its loss is a strong predictor of poor clinical outcome in luminal breast cancer. GATA3 also plays an important role in renal development and differentiation during embryogenesis, but little is known about the role of GATA3 in the adult human kidney."

"Now it looks like GATA
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Information Association (DIA) Announces New Clinical Safety and Pharmacovigilance Certificate Program
2. FDA Issues Guidance to Help Streamline Medical Device Clinical Trials
3. Clinical course of subepithelial lesions
4. Pluromed Announces Completion of Enrollment in LeGoo™ Cardiac Bypass Clinical Trial
5. Landmark Textbook Aims to Improve Clinician, Consumer Understanding of Lesbian Health
6. NHLBI funds preclinical tests on devices for infants and children with congenital heart defects
7. Chiropractors at Lyn Lake Chiropractic Clinic Provide Minneapolis, MN, Resource As Official MyFoxTwinCities.com ASK THE EXPERTS Sponsor
8. Medpedia Launches New Clinical Trial Platform
9. Macomb County Announces New Location for Four Upcoming H1N1 Clinics
10. Most Antidepressants Miss Key Target of Clinical Depression
11. Dr. David Williams Announces Launch of New Online Digestion Clinic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 For Dr. Iris Hunter, ... money; it’s an extension of her life’s mission. Her extensive ... as the owner of FirstLight HomeCare, make it clear that ... to me that my work makes a difference in the ... entrepreneurial spirit, so after much research, I felt ready to ...
(Date:10/22/2014)... California (PRWEB) October 22, 2014 Hay House ... Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written ... of Yoga & Recovery. This book is meant to ... in a life of recovery. , Recovery 2.0 is ... 12 Steps; Recovery 2.0 is a guide for what comes ...
(Date:10/22/2014)... Weight Your Body’s Way , In a world where a ... certainly can be difficult to choose the right weight loss ... doing it the healthy way? Set aside the fads and ... exercise regularly, and choose foods with the most nutritional benefits. ... to exercise more and eat less. Despite the number of ...
(Date:10/22/2014)... Steven Reinberg HealthDay Reporter , ... add weight and length may be showing a genetic propensity ... adults, certain genes have been linked to increased body fat, ... fat and lean muscle, the researchers said. At 1 ... By ages 2 and 3, however, these genes were linked ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Measures taken by ... in Ebola-ravaged Liberia may have limited the spread of ... report. The Firestone Natural Rubber Co. provides health ... residents of nearby densely populated communities. Between Aug. ... suspected Ebola cases among those 80,000 people. That incidence ...
Breaking Medicine News(10 mins):Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2
... refugees in unofficial camps are living in slum conditions redolent ... the Journal of Epidemiology and Community Health. , The research ... Gaza Displacement Centre in Beirut, Lebanon in May 2003. , ... lived in, access to outside air, the presence of mould ...
... release is also available in Spanish . ... expert on nutrition, studied the health benefits of the ... studies on the benefits of olive oil have been ... and Greece (the main olive-oil-producing countries), the incidence of ...
... increase , , THURSDAY, Jan. 17 (HealthDay News) -- The ... three decades, according to a new report released Thursday. ... Jones, senior research associate at the Guttmacher Institute, a ... will be published in the March issue of the ...
... Jan. 17 Cardiva Medical, Inc., a,privately held ... System is pleased to announce the addition of ... Cardiva as Vice President,of Finance and Chief Financial ... Business Development and Marketing., "We are very ...
... Pa., Jan. 16 With Gov. Ed,Rendell refusing to ... Exec. Dir. of the more than 65,000-member Council 13,AFSCME, ... is,mobilizing retiree members to fight back. AFSCME recently sent ... call the governor and to send,provided postcards urging him ...
... SEATTLE, Jan. 16 Hagens Berman Sobol Shapiro has ... ) and,Schering-Plough (NYSE: SGP ), manufacturers of Zetia ... Merck and Schering-Plough,violated state consumer protection laws arising from ... is the combination of Zetia and Zocor, a statin ...
Cached Medicine News:Health News:Palestinian refugees living in 'slum conditions' 2Health News:Consuming extra virgin olive oil helps to combat degenerative diseases such as cancer 2Health News:U.S. Abortion Rate Falls to Lowest Level in Decades 2Health News:U.S. Abortion Rate Falls to Lowest Level in Decades 3Health News:Cardiva Medical, Inc. Appoints Two New Officers: Malcolm Farnsworth as Vice President of Finance and Chief Financial Officer and Tara Zerby as Vice President of Business Development and Marketing 2Health News:AFSCME to Gov. Rendell: Don't Cut Health Benefits for State Retirees! 2Health News:Hagens Berman Sobol Shapiro Announces Investigation Into Marketing of Vytorin and Zetia 2Health News:Hagens Berman Sobol Shapiro Announces Investigation Into Marketing of Vytorin and Zetia 3
(Date:10/22/2014)... , Oct. 22, 2014   Foundation ... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ) ... genomic profiling to biopharmaceutical companies conducting clinical trials in ... the terms of the collaboration, Foundation Medicine will license ... Foundation Medicine,s FoundationOne® assay at the WuXi Genome Center ...
(Date:10/20/2014)... 2014  Luoxis Diagnostics, Inc., a subsidiary of ... that its academic collaborators will present several peer-reviewed ... its novel RedoxSYS Diagnostic System, a first-in-class platform ... in response to injury or illness.  A poster ... clinical marker will be presented by Christopher ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., a ... antibodies, today announced the appointment of Marco ... Londei will lead the preclinical and clinical development ... "We are pleased to welcome Dr. Londei to ... , President and Chief Executive Officer of AnaptysBio. ...
Breaking Medicine Technology:Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 2Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 3Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 4Luoxis to Highlight RedoxSYS at Two Upcoming Scientific Conferences 5AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... Workers Ensure Emergency Deliveries are Transported , ... chapter of the American Red Cross are hard at work ... endure that could potentially put Philadelphia,s blood supply at risk. ... up a picket line yesterday when their issues were ignored ...
... , , SALT LAKE CITY, Dec. 4 ... signed a sole-source vendor agreement to provide therapy equipment and ... in Tennessee and Georgia. , "We are pleased to ... Larry K. Beardall, executive vice president of sales and marketing ...
Cached Medicine Technology:Striking Red Cross Workers Raise Public Awareness of Unsafe Working Conditions 2
... neurodiagnostic for basic and advanced ... a large 12.1" XGA (1024 ... and the latest in technology ... speed, advanced NCS capabilities, advanced ...
... is a non-invasive and painless method of ... Cadwell Laboratories manufactures two magnetic stimulation devices, ... Stimulator (HSMS). The Hight Speed ... rates up to 25 Hz at full ...
... illuminated hand-held potential vision tester measures retinal ... glaucoma. Potential vision testing requires two ... or RAM (formerly known as the Illuminated ... (clip with a pinhole disc and hinged ...
... MOBEE headboxes are ... Xltek's line of portable ... with a robust new ... latest software, XLTEK's standard ...
Medicine Products: