Navigation Links
Mayo Clinic researchers find drug duo kills chemotherapy-resistant ovarian cancer cells
Date:12/7/2011

JACKSONVILLE, Fla. -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida. Their report, published online in Gynecologic Oncology, suggests that this combination (ixabepilone and sunitinib), might offer a much needed treatment option for women with advanced ovarian cancer. When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it.

"Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance which may be what this combination of agents is doing would be a boon to treatment of this difficult cancer," says study co-author Gerardo Colon-Otero, M.D., a hematologist-oncologist who cares for ovarian cancer patients.

The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. The study's senior investigator, cancer biologist John Copland, Ph.D., has identified RhoB as a key modulator for drug response in other tumor types, but says its role in ovarian cancer was unknown before this study.

"Now we find that with this combination of drugs, RhoB is increased and cells die," he says.

The study was possible because Dr. Copland and his laboratory colleagues, including co-author Laura Marlow, created and characterized two new ovarian laboratory cell lines. They were derived from tumor tissue specimens taken from a patie
'/>"/>

Contact: Kevin Punsky
Punsky.Kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pycnogenol® found to improve memory and test scores in college students in new clinical trial
2. American Society of Clinical Oncology issues annual report on progress against cancer
3. Novocure establishes initial Clinical Centers of Excellence for Treatment of Recurrent Glioblastoma Multiforme with Tumor Treating Fields Therapy
4. Mayo Clinic research improves diagnosis and potential treatment of neuromyelitis optica
5. Newly established neuroscience clinical trials center could bring treatments to patients faster
6. 2011 ASH Annual Meeting to highlight latest hematology research, clinical care breakthroughs
7. BMC resident receives American Society for Clinical Pathology awards
8. First whole-genome sequencing clinical trials for triple-negative breast cancer presented
9. Researchers validate preclinical effectiveness of TB drug target
10. Use of retail medical clinics rises 10-fold over 2-year period, study finds
11. AAOS issues new clinical practice guideline for treating common elbow fractures in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... ABILENE, Texas (PRWEB) May 27, 2015 ... addition of three FDA-approved dermal filler treatments in Abilene, ... designed to reduce the appearance of glabellar lines, better ... lines. Belotero Balance® is designed to treat smoker’s ... mouth to the chin, while Radiesse® improves the appearance ...
(Date:5/27/2015)... CA (PRWEB) May 27, 2015 Coco Libre ... will be able to reach for Organic Coconut Water to ... Libre will be available at VIP areas, artist greenrooms, corporate ... be available at area hotels and on festival shuttle buses. ... partner this year,” said Noa Elan, Director of Strategic Partnerships ...
(Date:5/27/2015)... Genius Monkey is pleased to announce that ... they have boosted sales for the Utah Honda Dealers ... for seven Utah-based dealers. , Until recently, the ... media. In 2014 the Utah Honda dealers changed their ... Monkey , shifted their marketing campaigns more towards targeted ...
(Date:5/27/2015)... West Des Moines, Iowa (PRWEB) May 27, 2015 ... and time ticking away, a poll conducted during the ... the 200 webinar poll participants, 75% are currently in ... and a little over 15% were confidently prepared for ... timeline that was shown during the webinar, those who ...
(Date:5/27/2015)... 27, 2015 Decorview , a ... is offering free design advice to homeowners looking to ... , “Light pollution caused by streetlights, outdoor signs, full ... night’s sleep, said Kim Rush, VP of sales and ... across North America with recently installed LED streetlights– the ...
Breaking Medicine News(10 mins):Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Coco Libre Puts Organic Coconut Water on the Line-up at BottleRock Napa 2Health News:Genius Monkey Boosts Utah Honda Dealers Website Traffic 142% 2Health News:Employers are On Track for ACA Reporting According to Businessolver Poll 2Health News:Decorview Helps Homeowners Combat Light Pollution 2
... The surge of funds for bioterrorism preparedness over the ... public health resources in general, according to research from ... departments does spur epidemiologic activity that is key in ... communicable disease like influenza or tuberculosis, at the local ...
... , ... have combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis ... ... srl have combined their industry leading technologies to provide the most sensitive tools for monitoring ...
... ... ... ... ...
... less likely to buy pizza, soda when the price went up, ... the cost of junk food increases, people consume less of it, ... habits and health of 5,115 young adults, aged 18 to 30, ... During those 20 years, a 10 percent increase in price was ...
... ... ... 2010 -- Students interested in pursuing a career in health care or business have ... vocational trainer – has opened a campus in Richmond, BC (see http://www.cdicollege.ca/British_Columbia/Richmond/Campus ). ...
... ... Next Great Young Chef Contest. , ... York, NY (PRWEB) March 9, 2010 -- KIWI Magazine has launched it,s second annual Next Great ... panel of prestigious judges will help to pick the next generation of culinary experts. To enter, ...
Cached Medicine News:Health News:Study: Federal funds support health depts., but leadership is key 2Health News:Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies 2Health News:MedQuist Wins Contract with Detroit Medical Center for Emergency Medicine Transcription at Six Healthcare Organizations 2Health News:MedQuist Wins Contract with Detroit Medical Center for Emergency Medicine Transcription at Six Healthcare Organizations 3Health News:MedQuist Wins Contract with Detroit Medical Center for Emergency Medicine Transcription at Six Healthcare Organizations 4Health News:Cost of Junk Food May Influence Consumption 2Health News:CDI College Opens a New Campus in Richmond 2Health News:KIWI Magazine Announces the Next Great Young Chef Contest--for Kids Who Love to Cook 2
(Date:5/27/2015)... WINNIPEG, Manitoba , May 27, 2015 /PRNewswire-USNewswire/ ... American customers, the Canadian International Pharmacy Association ... prescription medications online from licensed Canadian pharmacies. Approximately 64% ... health maintenance medications from a non-U.S. pharmacy due ... medications are not covered under their insurance plan.   ...
(Date:5/27/2015)... Calif. , May 27, 2015  Genomic Health, Inc. ... , Chief Operating Officer and Chief Financial Officer, will present ... New York City on Monday, June 1 at ... live and subsequently archived webcast of the presentation, go to ... http://investor.genomichealth.com .  Please connect to the web site at ...
(Date:5/27/2015)... DUBLIN, Ohio , May 27, 2015 /PRNewswire/ ... present a new series of health economic outcomes ... evaluating real-world treatment patterns when developing value-based reimbursement ... , vice president and chief medical officer of ... and pharmaceutical companies alike have known for more ...
Breaking Medicine Technology:Canadian International Pharmacy Association (CIPA) Survey of Americans Finds 64% Purchase Medications from Canada Due to Affordability 2Canadian International Pharmacy Association (CIPA) Survey of Americans Finds 64% Purchase Medications from Canada Due to Affordability 3Genomic Health to Present at the Jefferies 2015 Global Healthcare Conference 2Genomic Health to Present at the Jefferies 2015 Global Healthcare Conference 3New Studies Reinforce Important Role Real-World Patient Data Can Play in Developing Value-based Reimbursement Strategies 2New Studies Reinforce Important Role Real-World Patient Data Can Play in Developing Value-based Reimbursement Strategies 3
... WIRE)--Jun 27, 2007 - Annals of,Internal Medicine has ... the impact of genistein on bone loss. The ... in Osteopenic,Postmenopausal Women-A Randomized Trial," appears in the ... and efficacy of,genistein for the dietary management of ...
... - Opexa,Therapeutics, Inc. (NASDAQ:OPXA), a company involved ... presented,poster presentations at the 5th International Society ... Cairns, Queensland, Australia,from June 17-20 and at ... for Cellular Therapy (ISCT) in Sydney, Australia ...
Cached Medicine Technology:New Proof of Genistein's Efficacy and Safety for Osteopenia and,Osteoporosis Published in Annals of Internal Medicine 2New Proof of Genistein's Efficacy and Safety for Osteopenia and,Osteoporosis Published in Annals of Internal Medicine 3Opexa Advances Monocyte Derived Islet Technology to Proof of,Principle in stz-induced NOD/SCID Mice 2Opexa Advances Monocyte Derived Islet Technology to Proof of,Principle in stz-induced NOD/SCID Mice 3
... FDT is a breakthrough in visual field ... used in pre-test.,Introducing FDT, the first visual ... and compact enough to be used even ... of research and clinical trials behind it ...
... results. The Kowa AP-340 a new concept ... system of ultimate simplicity. Quick, comfortable procedure ... a compact, unique design profile weighing just ... features.The integration of CRT display and instrumentation ...
... Endoprosthesis is an innovative device designed to ... patients with abdominal aortic aneurysms (AAA). It ... graft with an outer self-expanding Nitinol support ... material durability. The function of the endoprosthesis ...
... Using a cast saw to remove a ... create anxiety in patients. Occasionally patients are cut ... DE-FLEX Protective Strip enables healthcare professionals to remove ... removal aid provides protection against cuts and burns ...
Medicine Products: