Navigation Links
Mayo Clinic researchers find common gene disorder doubles risk of lung cancer, even among nonsmokers
Date:5/26/2008

er among patients with COPD may be a result of lung tissue damage from emphysema, or chronic infection or inflammation of the lungs, or both," she says.

Individuals who are 1ATD carriers should have lung function checked on a routine basis and should avoid potential lung carcinogens. "We found people who carry these genes are more vulnerable to carcinogen-containing tobacco smoke, even secondhand smoke, than noncarriers," says Dr. Yang.

In this study, a team of 12 researchers looked at three different groups: 1,443 patients with lung cancer treated at Mayo Clinic from 1997 to 2003; a control group of 797 residents in the community; and a second control group of 902 siblings of the lung cancer patients. They found that:

The 1ATD carrier rate among 1,443 genotyped patients with lung cancer was 13.4 percent, compared to 7.8 percent among unrelated control participants.

All 1ATD gene carriers were at a similarly greater risk of developing lung cancer, regardless of smoking status. Those who had never smoked were at a 2.2-fold higher risk; light smokers had a twofold greater risk; and moderate to heavy smokers had a 2.3-fold increased risk. Although there's no absolute definition, less than 20 pack-years of smoking cigarettes is defined as light; more than 40 pack-years as heavy. A pack-year is the number of packs of cigarettes smoked per day multiplied by the number of years the person has smoked.

A history of COPD increased lung cancer risk significantly for light, moderate and heavy smokers, but affected those who had never smoked the most X an almost sixfold increased risk.

Increased lung cancer risk among 1ATD carriers is independent of a family history of lung or other cancers.

The estimated attributable risk for 1ATD carriers in this study among those who never smoked and among heavy smokers was 11 percent to 12 percent, suggesting that the genetic disorder might explain a significant proportion
'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bioniche Presents Pre-Clinical Research at Two International Conferences
2. Unlocking the promise of clinical and translational science
3. The Oregon Clinic Extends Patient Care Services Across Metro Portland with Time Warner Telecoms Metro Ethernet Service
4. China Biologic Products Announces Approval for the Relocation of Fang Cheng Plasma Collection Station and for the Procurement of Excess Clinical Plasma
5. CME Publication Gives Clinicians a Leg Up in Treating Disorders of the Lower Extremities
6. New Anticoagulation Management Software Helps Clinics Enhance Efficiency and Improve Patient Safety
7. Mayo Clinic Research Shows U.S. Intensive Care Units Prevention of Pneumonia in Critically-ill Patients Generally Strong; Identifies Area of Improvement
8. Rochester Coalition and Mayo Clinic Challenge Railroads Contention That Hazmat Rail Shipments Pose no Risk
9. Forty-Two Free Clinics Across State Share $1 Million in Grants From Blue Cross Blue Shield of Michigan
10. Clinical Solutions Subscribes to NetSuite for Global Healing of Disparate Operations
11. Shared Health(R) and Novo Innovations Partner for Improved Information-Sharing of Clinical Health Records
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... An article ... pizza maker Paul LaRocco has gone through to open a pizzeria in Westchester. Mr. ... process tends to take several months, but the current process, having already gone on ...
(Date:8/28/2015)... ... ... For Dallas, the time is nearing for the annual Heart Walk, and North ... American Heart Association hosts their well-known Heart Walk to raise money in awareness and ... be made. Walkers can participate in the cause and someone can also donate, even ...
(Date:8/28/2015)... Baltimore, MD (PRWEB) , ... August 28, 2015 , ... ... reduction system from Merz, received FDA clearance for results that last for two ... clearance is exciting news for patients who are looking for a long-lasting, effective solution ...
(Date:8/28/2015)... ... August 28, 2015 , ... On May 30th, 2015, Best Drug ... of the “Music With A Mission” benefit concert in Mendon, IL. Held in the ... raise money to support music education programs in the underfunded local school districts of ...
(Date:8/28/2015)... ... August 28, 2015 , ... Saint Petersburg, FL —Pocket Protein™, ... fat, carbs, sugar, gluten, lactose or caffeine in a convenient 2 oz. pouch ... CPG Editor’s Choice Awards. , Five consumer packaged goods (CPG) products were selected ...
Breaking Medicine News(10 mins):Health News:Article on Building Approval Process for LA Business Highlights the Need for a Bridge Between Businesses and City Officials, says Fire Protection Group Inc. 2Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
... impact predicted to be mild , TUESDAY, Dec. 8 (HealthDay ... impact of the H1N1 swine flu pandemic during the autumn-winter ... , "As more detailed data have become available, we ... this disease is. Early on, it was difficult to measure ...
... following was released today by Randall Terry, Director, Operation Rescue ... team members will travel to 13 Cathedrals in 9 states ... at the Boston Cathedral, the seat of Cardinal O,Malley, the ... Kerry families. , They will ask Catholic Bishops: "Your ...
... ... MDRX ) Chief Executive Officer Glen Tullman will host a webcast ... to introduce two new innovations: Allscripts Professional(TM) EHR 9.0 ... Record for small- and medium-sized physician groups; and Allscripts Remote ...
... HUNTINGTON BEACH, California and AMSTERDAM, December 8 ,Agendia, ... will be presenting six studies focusing on MammaPrint(R) at the ... conferences in,breast cancer research worldwide. The SABCS will take place ... Antonio, Texas, USA. , Agendia,s studies ...
... , CINCINNATI, Dec. 8 ... leading provider of document workflow solutions for hospitals, today announced ... technology to improve quality and operating efficiency by providing their ... their healthcare enterprise. The implementation of the Company,s enterprise ...
... YORK, Dec. 8 Parenting a family of any size or ... is that in this "second family," the parenting does not involve ... , According to William Bryan, Ph.D., cofounder of Active Seniors ... define this particular phenomenon that affects 10 million households where an ...
Cached Medicine News:Health News:Swine Flu Pandemic May Be Less Severe Than Expected 2Health News:Abortion, Bishops, and Healthcare: Announcing 'Deaf at the Cathedral' Tour in Nine States. 2Health News:Allscripts Launches New Innovations in Live Event 2Health News:Allscripts Launches New Innovations in Live Event 3Health News:Allscripts Launches New Innovations in Live Event 4Health News:Allscripts Launches New Innovations in Live Event 5Health News:Allscripts Launches New Innovations in Live Event 6Health News:Agendia to Present Broad Array of Data at 2009 San Antonio Breast Cancer Symposium 2Health News:Agendia to Present Broad Array of Data at 2009 San Antonio Breast Cancer Symposium 3Health News:Moses Cone Health System Selects Streamline Health to Enhance the Electronic Medical Record 2Health News:Moses Cone Health System Selects Streamline Health to Enhance the Electronic Medical Record 3Health News:Moses Cone Health System Selects Streamline Health to Enhance the Electronic Medical Record 4Health News:'Sandwich Generation' Avoids Unnecessary Stress While Tending to Aging Senior Parents 2
(Date:8/28/2015)... According to a new market ... Prostate) Type (Protein & Genetic Biomarkers) Profiling Technology (Proteomics, ... Geography - Global Forecast to 2020", published by MarketsandMarkets, ... 17,689.0 Million USD by 2020 at a CAGR of ... Browse 191 Tables and 38 F ...
(Date:8/28/2015)... Research and Markets ( ... "Investigation Report on China,s Tobramycin Market, 2010-2019" report ... antibiotic whose eye drop and ointment are the most ... or inflammation caused by eye infection. Currently, dozens of ... to produce tobramycin, among which the Top 5 are ...
(Date:8/28/2015)... Research and Markets ( ... "Investigation Report on China,s Insulin Aspart Market, ... Developed by Novo Nordisk, insulin aspart (under the ... for the treatment of diabetes. Compared with human ... analog, starts working fast and reports higher peak ...
Breaking Medicine Technology:Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 2Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 3Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 4Cancer Biomarkers Market Worth 17,689.0 Million USD by 2020 5Investigation Report on China's Tobramycin Market, 2015-2019 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2
... SOUTH SAN FRANCISCO, Calif., May 6 Exelixis,Inc. ... for the first quarter,ended March 31, 2008., ... were $27.9 million,compared to $28.1 million for the ... consistent with 2007, but reflect the completion of,revenue ...
... DIEGO, May 6 TriLink BioTechnologies (TriLink), ... has been awarded a,Phase II Small Business ... continue its investigation of modified dNTPs to ... studies demonstrated that TriLink,s,unique dNTP modifications enhanced ...
Cached Medicine Technology:Exelixis Announces First Quarter 2008 Financial Results 2Exelixis Announces First Quarter 2008 Financial Results 3Exelixis Announces First Quarter 2008 Financial Results 4Exelixis Announces First Quarter 2008 Financial Results 5Exelixis Announces First Quarter 2008 Financial Results 6TriLink Awarded a Phase II Grant for a Second Hot Start PCR Project 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: