Navigation Links
Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
Date:5/14/2012

ROCHESTER, Minn. -- Alterations to the "on-off" switches of genes occur early in the development of prostate cancer and could be used as biomarkers to detect the disease months or even years earlier than current approaches, a Mayo Clinic study has found. These biomarkers known as DNA methylation profiles also can predict if the cancer is going to recur and if that recurrence will remain localized to the prostate or, instead, spread to other organs. The study, published in the journal Clinical Cancer Research, is the first to capture the methylation changes that occur across the entire human genome in prostate cancer.

The discovery could someday help physicians diagnose prostate cancer earlier and make more effective treatment decisions to improve cure rates and reduce deaths. It also points to the development of new drugs that reverse the DNA methylation changes, turning the "off" switch back "on" and returning the genetic code to its normal, noncancerous state.

"Our approach is more accurate and reliable than the widely used PSA (prostate-specific antigen) test," says senior author Krishna Donkena, Ph.D., a Mayo Clinic molecular biologist.

The PSA test detects any prostate abnormality, whether inflammation, cancer, infection or enlargement, while the DNA methylation changes are specific to prostate cancer, she says.

Though the instructions for all the cell's activities lie within the genes, whether a particular gene is turned "off" or "on" is determined by the presence or absence of specific chemical tags or methyl groups methylation along the underlying DNA of cells. When this process of DNA methylation turns off the activity of tumor suppressor genes, cancer develops.

Dr. Donkena and her colleagues analyzed the methylation status of 14,495 genes from 238 prostate cancer patien
'/>"/>

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Automated insulin dosage titration system demonstrates positive clinical study results
2. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
3. Analysis Finds Clinical Trials Often Small, of Poor Quality
4. URMC clinical trial tests new regimen for hypertension
5. Mayo Clinic: Obesity epidemic fueling rise in rheumatoid arthritis among women
6. Association for Psychological Science, SAGE launch Clinical Psychological Science
7. Awards celebrate clinical research that can improve health and alleviate suffering
8. Kroenke honored for outstanding contributions in clinical research training
9. Mayo Clinic breast cancer study finds new type of mutation
10. NYU Langone experts present research, clinical advances at neurosurgeons meeting
11. Mayo Clinic offers newly approved treatment for acid reflux disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... 25, 2013 According to an article in ... a Feeling,” nearly 30 million Americans tan indoors each year ... despite knowing the health risks. New research suggests ... addictive effect on the brains of some tanners (Go to ... article so I can’t say that I fully support this ...
(Date:5/25/2013)... Chandler, AZ (PRWEB) May 25, 2013 ... whitening service page in partnership with JD Media Surge, ... whitening methods are now available and, depending on the ... home. During a routine visit, the best method will ... whitening is performed during a visit. A special peroxide-based ...
(Date:5/25/2013)... (HealthDay News) -- Many viruses and parasites that affect ... -- a bacteria-borne illness than can result in liver ... parks, according to a veterinarian. These germs ... the air, said Dr. Susan Nelson, a clinical associate ... of these serious diseases can be fatal, even with ...
(Date:5/25/2013)... St Louis, MO (PRWEB) May 25, 2013 ... goal for the Diet Doc team of weight management professionals. ... weight fast and effectively, Diet Doc’s hCG diets ... uncontrollable factors like abuse during childhood like bullying, more control ... not directly capable of dealing with the underlying factors of ...
(Date:5/25/2013)... 25, 2013 By working diligently for ... the integration of the 2012 Lamborghini Aventador into their ... latest entrant in the list of vehicles lined by ... is all set to thrill automobile lovers in the ... and spectacular looks, the 2012 Lamborghini Aventador comes with ...
Breaking Medicine News(10 mins):Health News:Sun Damage – Are UV Rays Addictive? 2Health News:Chandler Dentist Launches Teeth Whitening Service Page on Website in Partnership with JD Media Surge, LLC 2Health News:Hidden Dangers Dog Dog Parks 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 3Health News:Rim Fitments Provider SizeItUp Launches The Database Integration For The 2012 Lamborghini Aventador 2
... of Archives of Surgery,Individuals with diabetes appear to spend ... more ventilator support and have more complications during hospitalization ... million Americans have diabetes, with one-third remaining undiagnosed, according ... complications more frequently and do worse after an acute ...
... of Chikungunya, the ruling Left Democratic Front (LDF) ... 'politically correct' low-cost health cover plan . ... dumped its BPL (below poverty line) health cover pact ... public sector insurance partner. ,When asked about the delay ...
... or removal of the tonsils, none reported an ongoing ... . ,Together with the sense of smell ... taste contributes considerably to flavor perception during eating and ... enjoyment of foods and beverages, according to background information ...
... player Ben Czislowski was in for a shock when it was ... a rival's tooth dangerously embedded in his forehead . ... had the tooth removed last week by a doctor who made ... Matt Austin, who broke his jaw in a nasty head clash ...
... review of studies,School-based sexual abuse prevention programs can teach ... behaviors. ,However, the programs have a downside: ... strangers, the review cautions. ,,It was a concern ... the review, but we were pleased that there was ...
... recent study in JAMA reports that the risk of ... who adopted a diet very high in vegetables, fruit and ... compared to women who followed a diet of five or ... diet). ,'Considerable evidence from preclinical studies indicates that plant-derived ...
Cached Medicine News:Health News:Diabetes may Lead to More Complications 2Health News:Kerala Government Battles With Chikungunya On All Counts 2Health News:Patients Undergoing Tonsillectomy Shows No Change of Taste 2Health News:Lost And Found -Tooth In A Sportsman's Head 2Health News:School-based Sexual Abuse Prevention Programs 2Health News:School-based Sexual Abuse Prevention Programs 3Health News:Breast Cancer Risk is not Reduced by a Diet Rich in Fruit and Vegetables 2
(Date:5/23/2013)... 2013 3SBio Inc. (NASDAQ: ... China -based biotechnology company focused ... announced today that, at an extraordinary general meeting ... in favor of the proposal to authorize and ... merger dated February 8, 2013, among Decade Sunshine ...
(Date:5/23/2013)... Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced today ... Executive Officer of Neurocrine Biosciences, will be presenting at the ... in Boston.   The live presentation takes place ... 8:20 a.m. Pacific Time.  The presentation will be webcast and ... . If you are unable to attend ...
(Date:5/23/2013)... , May 23, 2013 Nephros, Inc. (OTC ... medical device company that develops and sells high performance ... its rights offering.  In addition, the concurrent temporary reduction ... expired on May 17, 2013. Nephros estimates ... from the rights offering.   A portion of the proceeds ...
Breaking Medicine Technology:3SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3Nephros Announces Completion of Rights Offering 2Nephros Announces Completion of Rights Offering 3Nephros Announces Completion of Rights Offering 4
... -- Winner Medical Group Inc. (Nasdaq: ... medical dressings, medical disposables and non-woven fabric made ... announced that Mr. Jianquan Li, Winner Medical,s founder, ... the Distinguished Contribution award for 2010 by the ...
... 30, 2011 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... will present a company overview at Needham,s 10th Annual Healthcare ... at the New York Palace Hotel. A live ... "Investors & Media" section of the Company,s Web site, ...
Cached Medicine Technology:Winner Medical CEO Awarded and Appointed Position by CNITA 2Winner Medical CEO Awarded and Appointed Position by CNITA 3Winner Medical CEO Awarded and Appointed Position by CNITA 4
... leading provider of Telemedicine monitoring and ... outstanding service commitment to patients and ... transtelephonic testing devices that provide enhanced ... using standard telephone lines. TransMedEx's product ...
... is a leading provider of telemedicine ... with state-of-the-art technology deliver accurate, reliable ... healthcare professionals and clients in improving ... and ECG technology to gather patient ...
... CardioNet has developed a new, integrated ... allows heartbeat-by-heartbeat, ECG monitoring, analysis and ... Our service is initially focused on ... with arrhythmia. Time is of the ...
... The Solo microplate incubator is an ... incubating a single microplate up to ... incubates applications requiring higher temperatures up ... solution offering low cost and high ...
Medicine Products: