Navigation Links
Mayo Clinic researcher says improved detection of bladder tumors reduces cancer recurrence

CHICAGO -- Making tumors inside the bladder fluoresce red under blue light allows physicians to more easily find and remove them, substantially reducing the rate at which these cancers come back, says a Mayo Clinic physician who is presenting results of a large, multicenter international clinical trial.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Lance Mynderse describing the research, are available on the Mayo Clinic News Blog ( Clinic News Blog. These materials are also subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for the post is hvxaua1.

The findings, which are being reported at the annual meeting of the American Urological Association, show that this new diagnostic technique found more of the most common bladder tumors than the traditional white-light detection method in almost 17 percent of the patients, and demonstrated a 22 percent relative reduction in the recurrence rate within nine months of the procedure.

"This is the first demonstration that photodynamic diagnosis (PDD) cystoscopy along with the study drug (hexaminolevulinate) improves immediate detection, but more importantly reduces tumor recurrence rates of papillary bladder tumors; this is a significant improvement in treatment for our patients," says urologist Lance Mynderse, M.D., (, who practices at Mayo Clinic's campus in Rochester, Minn. The 766-patient phase III study was conducted in 28 U.S. and European centers, and its principal investigator is Barton Grossman, M.D., of The University of Texas M.D. Anderson Cancer Center. Dr. Mynderse is presenting study results as spokesman for the lead enrolling site in North America.

Bladder cancer ( is a dangerous, very time-consuming and expensive cancer to treat, primarily because non-muscle invasive bladder tumors recur in up to 70 percent of patients, Dr. Mynderse says. "Once a cancer develops anywhere in the bladder, it can come back in another place, rather like skin cancer recurrences," he says. As a result, patients need to be re-examined every three to six months, and that means physicians need to examine the bladder from within, using a thin tube known as a cystoscope that has a lens and uses white light to illuminate the area. Additional testing is commonly performed and includes urine tests and radiographic studies. Once a tumor is detected, it is removed and then analyzed by histopathology.

The study compared use of the traditional white-light cystoscopy with photodynamic diagnosis using a special light source and lenses that can switch from white to blue light. The blue light is designed for use with the study drug (hexaminolevulinate), which is instilled into a patient's bladder prior to the therapeutic procedure. This acts as a prodrug that initiates a series of biochemical reactions in malignant cells which result in significant, preferential accumulation of photoactive porphryins. When the blue light is turned on, the tumors emit a red fluorescence. "The cancers appear bright red compared to normal tissue, which is a lighter blue-green," Dr. Mynderse says. "It is quite dramatic. One sees bladder tumors in a whole new light."

This study enrolled patients with higher risk of tumor recurrence who had either multiple papillary noninvasive bladder cancers or papillary tumors that had recurred within a year of being treated. All patients received an examination with white-light cystoscopy, and half were randomized to receive the agent and blue-light examination. Investigators found that this new technology detected at least one additional Ta/T1 tumor in 16.9 percent of the 278 patients randomized to blue light.

There was also a 46 percent increase in detection of high-risk bladder cancers known as carcinoma in situ (CIS), using the blue-light technique, Dr. Mynderse says.

The researchers then looked at 402 patients with Ta/T1 tumors who completed the study, and found a significant reduction in tumor recurrence in patients diagnosed with fluorescence cystoscopy (36 percent), compared with patients in the white-light group (46 percent). "Using the blue light, it is much easier to tell when we have removed all the tumor in the bladder," Dr. Mynderse says. "When no fluorescence remains, we really have improved our effectiveness in ridding the patient of the cancer."

The American Cancer Society estimated that almost 69,000 new cases of bladder cancer were diagnosed in the U.S. in 2008, and about 14,000 people died of the disease. Bladder cancer is much more common in men, and smoking is the greatest risk factor.

The study was funded by Photocure ASA, a Norwegian pharmaceutical company that developed the fluorescent agent hexaminolevulinate (Hexvix) used in the study. Karl Storz Endoscopy-America, Inc, based in Germany, provided the Photodynamic Diagnosis (PDD) endoscopy instruments that were used. Use of fluorescence cystoscopy has been approved in Europe and is under consideration in the United States by the Food and Drug Administration.


Contact: Traci Klein
Mayo Clinic

Related medicine news :

1. Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation
2. Drug inhibits neuroblastoma blood supply in pre-clinical tests
3. Educating referring clinicians about advanced imaging leads to drop in imaging exams
4. Mayo clinic study finds gene bringing together animal and human research in alcoholism
5. Mayo Clinic Study Finds Gene Bringing Together Animal and Human Research in Alcoholism
6. Sickle cell treatment developed at LA BioMed approved for phase 3 clinical trial
7. Wound Management Technologies, Inc. Announces the Presentation of Evidence Based Clinical Studies at the Symposium on Advanced Wound Care Conference in Dallas
8. Only 10 Seconds to Care by Dr. Wendy S. Harpham helps heal clinician-patient bonds
9. InfoLogix Selected by Gwinnett Medical Center to Transform Clinical Care Through Next-Generation Mobile Communications Solution
10. FDA Gives Clinical Trial Green Light on Drug to Treat Alzheimers Disease
11. TOPICA Begins Phase 2 Clinical Trial of Potent Antifungal, Luliconazole, in Athletes Foot
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
Breaking Medicine Technology: