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Mayo Clinic researcher says improved detection of bladder tumors reduces cancer recurrence
Date:4/25/2009

CHICAGO -- Making tumors inside the bladder fluoresce red under blue light allows physicians to more easily find and remove them, substantially reducing the rate at which these cancers come back, says a Mayo Clinic physician who is presenting results of a large, multicenter international clinical trial.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Lance Mynderse describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/)Mayo Clinic News Blog. These materials are also subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for the post is hvxaua1.

The findings, which are being reported at the annual meeting of the American Urological Association, show that this new diagnostic technique found more of the most common bladder tumors than the traditional white-light detection method in almost 17 percent of the patients, and demonstrated a 22 percent relative reduction in the recurrence rate within nine months of the procedure.

"This is the first demonstration that photodynamic diagnosis (PDD) cystoscopy along with the study drug (hexaminolevulinate) improves immediate detection, but more importantly reduces tumor recurrence rates of papillary bladder tumors; this is a significant improvement in treatment for our patients," says urologist Lance Mynderse, M.D., (http://www.mayoclinic.org/bio/10475311.html), who practices at Mayo Clinic's campus in Rochester, Minn. The 766-patient phase III study was conducted in 28 U.S. and European centers, and its principal investigator is Barton Grossman, M.D., of The University of Texas M.D. Anderson Cancer Center. Dr. Mynderse is presenting study results as spokesman for the lead enrolling site in North America.

Bladder cancer (

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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