Navigation Links
Mayo Clinic research improves diagnosis and potential treatment of neuromyelitis optica
Date:12/2/2011

ROCHESTER, Minn. -- Mayo Clinic researchers have identified critical steps leading to myelin destruction in neuromyelitis optica (NMO), a debilitating neurological disease that is commonly misdiagnosed as multiple sclerosis (MS). The findings could lead to better care for the thousands of patients around the world with NMO. The paper was published in the journal, Proceedings of the National Academy of Sciences, USA.

NMO is an inflammatory autoimmune disease of the central nervous system that damages the optic nerves and spinal cord, causing vision loss, weakness, numbness and, sometimes, arm and leg paralysis and loss of bowel and bladder control. NMO was historically misdiagnosed as a severe variant of MS until 2005 when a team led by Vanda A. Lennon, M.D., Ph.D., a Mayo Clinic research immunologist, identified an antibody unique to NMO, and discovered that its unexpected target was the major water channel of the central nervous system (aquaporin-4). A blood test emerging from this discovery has revolutionized the diagnosis of NMO, allowing its distinction from multiple sclerosis and introducing more appropriate treatments.

The NMO antibody targets astrocytes, which are 10 times more numerous in the brain and spinal cord than neurons. In addition to providing nutrients to neurons and supporting the repair and scarring process, other critical functions of astrocytes include regulation of tissue water and electrical activities of neurons, and the stabilizing the protective covering of nerves (myelin). By attacking the water channels on astrocytes, the antibody disrupts all related dynamic functions of the astrocyte and in acute attacks kills many astrocytes.

The new findings advance the understanding of the basic mechanisms of NMO, critical to the ultimate development of optimal treatment or even a cure. Key findings include:

  • The antibody associated with NMO affects two forms of the aquaporin-4 water channe
    '/>"/>

Contact: Brian Kilen
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Newly established neuroscience clinical trials center could bring treatments to patients faster
2. 2011 ASH Annual Meeting to highlight latest hematology research, clinical care breakthroughs
3. BMC resident receives American Society for Clinical Pathology awards
4. First whole-genome sequencing clinical trials for triple-negative breast cancer presented
5. Researchers validate preclinical effectiveness of TB drug target
6. Use of retail medical clinics rises 10-fold over 2-year period, study finds
7. AAOS issues new clinical practice guideline for treating common elbow fractures in children
8. First MacLean Center Prize in Clinical Ethics awarded to Dartmouths John Wennberg
9. New screening method can detect a range of clinical conditions from a single dried blood spot
10. CDC and Prevention awards Mayo Clinic an international medical education grant
11. Mayo Clinic study confirms smoke-free workplaces reduce heart attacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... October 20, 2014 JZ Fitness, an ... coaching, corporate wellness programming, authorship, international lecturing and community ... to announce the release of the JZ Fitness nutrition ... years of coaching thousands of individuals on nutrition, Jenn ... that does not require calorie counting or cumbersome food ...
(Date:10/20/2014)... Rockynol Retirement Community broke ... 14. The $11 million project will include the latest ... kitchen with full-service restaurant style dining. , “We are ... class Assisted Living apartments,” said Kara Hanzie, Rockynol Executive ... quality of care and this investment is proof of ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The ... member hospital ROI on membership dues at 12.5. In other ... $12.50 in value to member hospitals. The calculation used to ... Dues. , “This is the first time we’ve actually ... the methodology is really sound,” said Bill Ryan , ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury law ... greater Phoenix area and across Arizona reports record demand ... automobile accidents. Statistics have indicated a steady increase in ... such, Hastings and Hastings has seen a steady increase ... have been injured through no fault of their own ...
(Date:10/19/2014)... Having been working in the garment industry for decades, ... According to James, one of the company’s top designers, many ... high-low skirts that add beauty to them. Chiffon floor length ... unveiled its new selection of 2014 long prom dresses. ... items are available in over 20 popular designs. The company ...
Breaking Medicine News(10 mins):Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... Legendary Recording Artist Chaka Khan, LOS ANGELES, ... the 1-millionth visitor to BODY WORLDS today. This ... record-breaking run for BODY WORLDS,at the California Science ... Chaka Khan and a group of middle school,students ...
... Escalon Medical,Corp. (Nasdaq: ESMC ) today announced ... State Food and Drug Administration within the,People,s Republic ... series,of products in that country. The PacScan(R) series ... both cataract and refractive,surgery. The E/Z- Scan(R) series ...
... Calif., April 3, 2008 IPC,The Hospitalist Company, ... of,hospitalist services, announced that it was added to ... Adam Singer, M.D., Chief Executive Officer, commented, "This ... publicly traded company. The,addition to the Russell 2000(R) ...
... 3, 2008 With spring here and,summer fast approaching, ... said, attractive feet are a MUST!, YogaToes(R) are ... feel great. YogaToes(R) beautify feet with passive exercise that,helps ... by tight,shoes, high heels and overexertion., "Women aren,t ...
... again in the,Texas Medical Center as Houston-based LifeGift becomes ... one of a handful in the nation --,with its ... that facility is expected to help save the lives ... "This building will provide us to the opportunity serve ...
... ... http://www.cryocath.com , MONTREAL, April 3 /PRNewswire-FirstCall/ ... cardiac arrhythmias, today,announced that data on the Company,s Arctic Front(R) catheter ... Meeting,of the German Cardiac Society in Mannheim, Germany, March 27-29, 2008.,CryoCath ...
Cached Medicine News:Health News:California Science Center Welcomes 1-Millionth BODY WORLDS Visitor 2Health News:Escalon(R) Announces China Registration for Sonomed PacScan(R) and E/Z-Scan(R) Series of A-scan, Pachymeter and B-Scan Systems 2Health News:Escalon(R) Announces China Registration for Sonomed PacScan(R) and E/Z-Scan(R) Series of A-scan, Pachymeter and B-Scan Systems 3Health News:IPC The Hospitalist Company Added to Russell 2000 Index 2Health News:New Ten-Minute Foot Exercisers Beautify Feet for Spring and Summer Sandal Season 2Health News:Houston-Based LifeGift Becomes State's Only Stand-Alone Organ and Tissue Recovery Agency 2Health News:CryoCath Reports Data Presented at the 74th Annual Meeting of the German Cardiac Society 2Health News:CryoCath Reports Data Presented at the 74th Annual Meeting of the German Cardiac Society 3
(Date:10/20/2014)... octubre de 2014  PneumRx, Inc. ( www.pneumrx.com ... pulmonología intervencional, anunció hoy la conclusión de la ... antes de lo programado. El Estudio Clínico RENEW es ... investigación (IDE) aprobada por la FDA (Administración de ... de reducción de volumen pulmonar PneumRx RePneu, un ...
(Date:10/20/2014)... , Oct. 20, 2014  ResMed (NYSE: ... the ResMed Data Exchange program, a comprehensive suite ... equipment (HME) and other health care providers. ... access to critical patient information. It integrates valuable ... and U-Sleep™ patient management platforms with customers, in-house ...
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
Nidek LM-990A accomplishes precise measurement, quick response and easy operation....
Autolensmeter with color 5.7 inch LCD screen and built in printer....
... The CF-60UVi is a diversified ... color, FAG, ICG (optional) with ... angle in the market), 40 ... in one picture and 30 ...
... AL200 is designed to eliminate the subjective ... error and providing repeatable, objective measurements every ... screen and icon-based operating system ensure fast ... operators to optimal lens positioning and, in ...
Medicine Products: