Navigation Links
Mayo Clinic research improves diagnosis and potential treatment of neuromyelitis optica
Date:12/2/2011

ROCHESTER, Minn. -- Mayo Clinic researchers have identified critical steps leading to myelin destruction in neuromyelitis optica (NMO), a debilitating neurological disease that is commonly misdiagnosed as multiple sclerosis (MS). The findings could lead to better care for the thousands of patients around the world with NMO. The paper was published in the journal, Proceedings of the National Academy of Sciences, USA.

NMO is an inflammatory autoimmune disease of the central nervous system that damages the optic nerves and spinal cord, causing vision loss, weakness, numbness and, sometimes, arm and leg paralysis and loss of bowel and bladder control. NMO was historically misdiagnosed as a severe variant of MS until 2005 when a team led by Vanda A. Lennon, M.D., Ph.D., a Mayo Clinic research immunologist, identified an antibody unique to NMO, and discovered that its unexpected target was the major water channel of the central nervous system (aquaporin-4). A blood test emerging from this discovery has revolutionized the diagnosis of NMO, allowing its distinction from multiple sclerosis and introducing more appropriate treatments.

The NMO antibody targets astrocytes, which are 10 times more numerous in the brain and spinal cord than neurons. In addition to providing nutrients to neurons and supporting the repair and scarring process, other critical functions of astrocytes include regulation of tissue water and electrical activities of neurons, and the stabilizing the protective covering of nerves (myelin). By attacking the water channels on astrocytes, the antibody disrupts all related dynamic functions of the astrocyte and in acute attacks kills many astrocytes.

The new findings advance the understanding of the basic mechanisms of NMO, critical to the ultimate development of optimal treatment or even a cure. Key findings include:

  • The antibody associated with NMO affects two forms of the aquaporin-4 water channe
    '/>"/>

Contact: Brian Kilen
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Newly established neuroscience clinical trials center could bring treatments to patients faster
2. 2011 ASH Annual Meeting to highlight latest hematology research, clinical care breakthroughs
3. BMC resident receives American Society for Clinical Pathology awards
4. First whole-genome sequencing clinical trials for triple-negative breast cancer presented
5. Researchers validate preclinical effectiveness of TB drug target
6. Use of retail medical clinics rises 10-fold over 2-year period, study finds
7. AAOS issues new clinical practice guideline for treating common elbow fractures in children
8. First MacLean Center Prize in Clinical Ethics awarded to Dartmouths John Wennberg
9. New screening method can detect a range of clinical conditions from a single dried blood spot
10. CDC and Prevention awards Mayo Clinic an international medical education grant
11. Mayo Clinic study confirms smoke-free workplaces reduce heart attacks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 23, 2015 The U.S. Pharmacopeial Convention ... Director of Clinical Pharmacy Services at North Carolina State’s ... of the 2015 Beal Award for Distinguished Volunteer Service—the ... relied on the contributions of volunteer experts to direct ...
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the ... created for kids with cancer. The Chemo Duck App, available on ... with enjoyable games to help children of all ages living with ... to keep kids entertained, educated and at ease while waiting for ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) ... to “Live Fearless.” , The “Faces of Fearless” ... about how they or someone they know has faced a ... the moment. By telling these types of stories through livefearlessmn.com, ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Thousand of ... Medical Care recalled its GranuFlo and NaturaLyte dialysis concentrates ... underway in U.S. District Court, District of Massachusetts, Bernstein ... 20th, the Court has remanded a case filed by ...
(Date:1/22/2015)... York, NY (PRWEB) January 22, 2015 ... College of Sports Medicine flagship journal Medicine & ... with L-Citrulline before exercise may help reduce gastrointestinal ... exercise. 1 , Participants in the double-blind, ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... Following today,s startling survey by,the Centers for ... youth,suicide in more than 15 years, the 125-year-old ... of expert tips and resources to help,youngsters, parents ... warning,signs, life-saving tips, and free resources to prevent ...
... cancer killer, study says , , THURSDAY, Sept. 6 (HealthDay News) ... 1950s coincided with a steady rise in the incidence of ... common form of the disease, a new study finds. , ... of lung cancer. But between 1950 and 2007, adenocarcinoma became ...
... that separate the minority of successful HIV antibodies from ... implications for future attempts to design an HIV vaccine. ... in the journal Nature. , This study is ... HIV occurs, says Dennis Burton, a professor at The ...
... YORK, Sept. 6 H.E.A.R.T 911 is a,non-profit, ... fire fighters and construction trade union workers, all ... September 11th attacks and,surviving family members of those ... respond nation-wide to situations that arise during,natural or ...
... Workshop Features CML Expert, Jorge Cortes, M.D., WHITE ... on leukemia, will discuss novel treatment approaches for chronic,myelogenous ... A,Model in Cancer Therapy. The program is scheduled for ... The program is being offered by The Leukemia ...
... IS SEPTEMBER 8, 2007 Veterinarians Remind Americans to,Vaccinate their ... to highlight the issue,that despite advances in prevention, rabies ... sixty thousand people die of rabies in the,world each ... the United States. Wildlife, like raccoons and skunks, ...
Cached Medicine News:Health News:Jump in Youth Suicide Prompts National Children's Charity KidsPeace to Issue Tips on Prevention, Warning Signs 2Health News:Jump in Youth Suicide Prompts National Children's Charity KidsPeace to Issue Tips on Prevention, Warning Signs 3Health News:Jump in Youth Suicide Prompts National Children's Charity KidsPeace to Issue Tips on Prevention, Warning Signs 4Health News:Filtered Cigarettes Blamed for Huge Rise in Type of Lung Cancer 2Health News:Filtered Cigarettes Blamed for Huge Rise in Type of Lung Cancer 3Health News:Filtered Cigarettes Blamed for Huge Rise in Type of Lung Cancer 4Health News:Scripps Research scientists shed new light on how antibodies fight HIV 2Health News:Scripps Research scientists shed new light on how antibodies fight HIV 3Health News:Retired NYPD Lieutenants William E. Keegan, Jr., Owen McCaffery and John Moran and Tom Thees, a former COO in the financial industry, announce today the formation of H.E.A.R.T (Healing Emergency Aid Response Team) 911. 2Health News:The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia 2Health News:The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia 3Health News:MultiVu Video Feed: PUBLIC HEALTH EXPERTS CONVENE TO DISCUSS THE TREATMENT AND PREVENTION OF RABIES 2
(Date:1/23/2015)... 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released a ... leaders and a new study analyzing the impact of increased cost ... nationwide coalition working to educate policy makers and the public on ... was focused on how the Iowa healthcare ...
(Date:1/23/2015)... , Jan. 23, 2015  Immune Therapeutics, Inc. today announced ... for the compounding, packaging and distributing of its naltrexone tablets. ... the United States . KRS Global ... naltrexone tablets in various strengths for individual patients in response ...
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned ... market share and grab a foothold in the hydroponic, hemp ... capabilities and a presence in the sector, and recently partnering ... growth of hemp and medical marijuana, iMD is committing to ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... -- China Medical Technologies, Inc. (the "Company") (Nasdaq: ... ("IVD") company, today announced that its subsidiary, Beijing GP ... sixth in the Deloitte Technology Fast 50 China 2010 ... molecular diagnostic businesses of the Company. The ...
... Oct. 21 Investigators from Texas Children,s Hospital ... North America came together in Houston to analyze ... the Berlin Heart EXCOR® Pediatric Ventricular Assist Device ... more about the study, see: http://bit.ly/bfrA1J ...
Cached Medicine Technology:China Medical Technologies Announces its Subsidiary, GP Medical, Ranked Sixth in Deloitte Technology Fast 50 China 2010 Program 2Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 2Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 3Texas Children's Hospital Hosts North American Investigators on Berlin Heart Trial 4
15" overall length, 9" handle....
15" overall length, 5" handle....
9.5" overall length, 4.5" handle....
15" overall length, 9" handle....
Medicine Products: