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Mayo Clinic reports possible new therapy for patients with platinum-resistant ovarian cancer
Date:10/23/2007

linical Cancer Research, 11:5935, 2005). The present Phase II trial was designed to extend this work and better determine this therapys effectiveness against platinum-resistant cancers.

Dr. Bible and his co-investigators treated 18 platinum-resistant Caucasian patients with this combination therapy. Of the 18 patients, all of whom were receiving the therapy as a second-line treatment after disease progression, one patient experienced complete response (all signs of cancer gone) and five other patients experienced partial responses (tumor regression). The 33 percent overall response rate (6 of 18 patients) is about twice as high as seen using traditional chemotherapy regimens.

The researchers also offered the combination therapy to five patients with platinum-sensitive (original therapy resulted in no recurrence for greater than 12 months) ovarian cancer. Of these women, one experienced complete response and three others partial response.

We now need to expand this trial to validate these interim results in additional patients, says Dr. Bible. Were also looking for ways to further boost the anti-cancer effects of the combination, in hopes of developing even more effective approaches to ovarian cancer.


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Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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