Navigation Links
Mayo Clinic reports new findings on noninvasive test for pancreatic cancer
Date:5/11/2011

ROCHESTER, Minn. - Pancreatic cancer has one of the highest mortality rates of any of the major cancers, and of the 43,000-plus Americans diagnosed with the disease each year, more than 94 percent die within five years of diagnosis. One reason for this high number of deaths is a lack of effective screening tools for catching the disease early. Now, in an effort to try to gain the upper hand on this deadly form of cancer, Mayo Clinic researchers believe they have found a new way to test for pancreatic cancer with DNA testing of patients' stool samples. The research was presented at the 2011 Digestive Disease Week conference, held May 7󈝶 in Chicago.

"We know with colon cancer that we can detect some molecular signatures of cancers and pre-cancers, and we were interested in trying to determine if we could do the same thing, specifically with a stool test, for pancreas cancer," says John Kisiel, M.D., Mayo Clinic gastroenterologist, who presented the study's findings.

The study focused on detecting methylations in stool samples of 127 patients, 60 diagnosed with pancreatic cancer and 67 who were not diagnosed with cancer. Methylation is a type of DNA modification strongly associated with cancers and pre-cancers. The research team wanted to test if they could reliably detect any types of methylated genes in the stool samples of those in the study group who had already been diagnosed with pancreatic cancer.

"We found that a marker was reliably detected in both tissue samples and in the stools of pancreatic cancer patients, and that it compared favorably with another kind of marker - the mutation of a gene called KRAS," says Dr. Kisiel. "When we looked at those two markers together, the combined accuracy of both markers was significantly better than with either marker alone." Overall, the methylated marker (called BMP3) and the mutated KRAS genes were detected in 70 percent of those in the study who had pancreatic cancer.

The screening detected the markers regardless of the stage of cancer or the location of the cancer within the pancreas. These findings may lead to more early detection of pancreatic cancer, which could significantly increase the survival rate for those who have the disease. The stool tests are also noninvasive, and samples can be collected by patients at home and sent to their doctor, without an office or clinic visit.

Ultimately, the researchers hope to expand on this initial study to create effective stool screenings for all the cancers that affect the gastrointestinal tract. "We now can reliably detect a methylation marker in stool that we know is present in curable stage cancers and similar markers have been found in pre-cancers," says Dr. Kisiel. "This is going to lead us to try to test additional patient tumor specimens for additional diagnostic markers of this type so that we can develop a panel of markers that could cover all the cancers and pre-cancers throughout the GI tract."


'/>"/>

Contact: Brian Kilen
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Watching how cancer patients interact online could help clinicians provide better services
2. Mayo Clinic researchers find new treatment for constipation
3. Mayo Clinic studies how much practice makes perfect when performing colonoscopies
4. Cedars-Sinais mobile medical clinics receive $500,000 grant from California Community Foundation
5. TGen licenses first drug for patient use in clinical care
6. Mayo Clinic CPR efforts successful on man with no pulse for 96 minutes
7. ENERCA clinical recommendations for sickle cell disease management and prevention in children
8. Mayo Clinic finds new genetic cause of neurodegeneration
9. Mayo Clinic finds robotic surgery effective for removing hard-to-reach throat cancer
10. UofL nursing faculty honored for race track clinic success
11. Tierney named 2011 Clinical and Translational Research Distinguished Investigator
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited to ... Recovery® program to drive cancer patients to and from their cancer treatments. Comfort ... quality of life and ongoing independence. Getting to and from medical treatments is ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Investment Group (TGIG), has initiated cultivation and processing operations at its production facility, ... Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of proactive ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... -- Dublin ... the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global market ... its applications in various applications. The report deals with ... main industries: pharmaceutical and biotechnology, food and beverage, and ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
Breaking Medicine Technology: