Navigation Links
Mayo Clinic moves small-molecule drugs through blood-brain barrier
Date:6/4/2014

ROCHESTER, Minn. Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.

"Not only have we shown that we can transport eight different molecules, we think this method will be less disruptive or invasive because it mimics a normal physiological process," says Mayo Clinic neuroscientist Gobinda Sarkar, Ph.D., the corresponding author of the study. The researchers are able to transport the drugs without modifying any of the molecules involved. They say this development will aid in evaluation of potential new drugs for brain cancer.

The blood-brain barrier is meant to protect the brain from numerous undesirable chemicals circulating in the body, but it also obstructs access for treatment of brain tumors and other conditions. Too often the only recourse is invasive, which often limits a drug's effectiveness or causes irreversible damage to an already damaged brain. Nearly all of the drugs that could potentially help are too large to normally pass through the barrier. Additionally, other methods may damage the vascular system.

In this case, the synthetic peptide K16ApoE, once injected into a vein, binds to proteins in the blood to create entities that can pass for near-normal ligands to some receptors present on the blood-brain barrier. The 'pseudo-ligand' receptor interaction creates what the researchers believe to be transient pores through which various molecules can be transported to the brain. The molecules they've transported in this manner include cisplatin, methotrexate, cetuximab, three different dyes, and synthetic peptides Y8 and I-125. The researchers believe this is the least complicated, least expensive and most versatile method for delivering therapeutics to the brain. Previously, the researchers delivered antibodies targ
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. First targeted nanomedicine to enter human clinical studies
3. Clinical insight improves treatment with new lung cancer drug
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Mayo Clinic launches whole genome breast cancer study
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Mayo Clinic breast cancer study finds new type of mutation
9. Kroenke honored for outstanding contributions in clinical research training
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Association for Psychological Science, SAGE launch Clinical Psychological Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... 30, 2015 , ... Ross A. Clevens, MD, FACS has been ... of Plastic Surgery. This is Dr. Clevens’ second appointment by the prestigious school. ... developing a strong presence and a valuable mentoring program for medical students. ...
(Date:7/30/2015)... ... July 30, 2015 , ... Western University of Health Sciences ... Special Olympics World Games, the largest sports and humanitarian event in the world this ... , The World Games, held July 25 through August 2, 2015, benefited from the ...
(Date:7/30/2015)... ... 30, 2015 , ... Ocean Hills Recovery has officially been accredited by CARF ... No recommendations means CARF found no areas in the OHR program that needed improvement, ... of all facilities receive. In addition, Ocean Hills was granted the maximum certification period ...
(Date:7/30/2015)... ... 30, 2015 , ... New research finds some distinct differences in the way ... on the Surviving Mesothelioma website. , Researchers with the National Institutes of Health, ... cases of mesothelioma occurring between 1990 and 2010. Two percent of these cases (207) ...
(Date:7/30/2015)... ... 30, 2015 , ... Political unrest is the number one ... new survey by leading international insurance provider Clements Worldwide. The "Clements Worldwide Risk ... the largest sources of financial losses among respondents. , Twenty-eight percent of top ...
Breaking Medicine News(10 mins):Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 2Health News:Leading Melbourne Facial Plastic Surgeon Reappointed by UCF 3Health News:WesternU Makes Big Impact at Special Olympics 2Health News:WesternU Makes Big Impact at Special Olympics 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2Health News:Study Finds Mesothelioma Behaves Differently in Younger People, According to Surviving Mesothelioma 2Health News:New Clements Worldwide Global Risk Survey Shows Political Risk and Instability Top Managers' Concerns 2Health News:New Clements Worldwide Global Risk Survey Shows Political Risk and Instability Top Managers' Concerns 3
... blood sugar namely blindness, malfunction of the kidneys are known. ... have now come out with astonishing details that a raise ... than 100 adults with type 1 diabetes hwo had four ... mouth, having a sweet taste in their mouth and needing ...
... the globe as 95% of the AIDS victims dwell ... Special Session on HIV/AIDS, physicians demanded to bring down ... the AIDS victims in developing countries. ,Dr. Anne-Valerie ... as Medicines Sans Frontieres, or MSF), MSF provides healthcare ...
... Heart Association's 41st Annual Conference on Cardiovascular Disease Epidemiology ... new cousin counterpart to heart disease-Asthma. It is found ... ,Carlos Iribarren, MD, MPH, PhD, of Kaiser Permanente, in ... had a risk of 33% towards developing the heart ...
... number of psychological benefits, including fighting stress-related physical and ... found no psychological benefit from the use of ginseng. ... the sport and exercise psychology lab at the Oregon ... Engles, PhD, conducted the study and found that there ...
... the major cause of morbidity in most of the ... reluctant to take extra vitamins or iron pills, as ... were effective for improving the iron status of young ... iron deficiency in children of low-to-middle income groups. These ...
... is an inherited disease of the nervous system due ... causing symptoms such as involuntary movements and balance problems ... speech as well. ,All these days, until now, ... a mutated form of the protein 'huntingtin' which is ...
Cached Medicine News:Health News:Asthma! A new warning for heart disease 2
(Date:7/29/2015)... OSAKA, Japan , ... -- ... confirmed,   including Core ... EPS    ... Underlying revenue +6.1% year-to-year (reported revenue growing +8.5% to 446.3 billion yen) ...
(Date:7/29/2015)... , July 29, 2015  Unilife Corporation ("Unilife" or ... a developer, manufacturer and supplier of injectable drug delivery ... strategy that provides the Company with flexibility and control ... Unilife has signed an equity purchase agreement for up ... ("LPC"), a Chicago -based institutional investor, ...
(Date:7/29/2015)... COPENHAGEN, Denmark , July 29, 2015  Ascendis ... biotechnology company that applies its innovative TransCon technology to ... will host a conference call on July 30, 2015, ... results from a Phase 2 pediatric study of once-weekly ... release of the top-line results before the market opens ...
Breaking Medicine Technology:Takeda Reports 1st Quarter Results of FY2015 with Underlying Revenue Growth of +6.1% 2Takeda Reports 1st Quarter Results of FY2015 with Underlying Revenue Growth of +6.1% 3Takeda Reports 1st Quarter Results of FY2015 with Underlying Revenue Growth of +6.1% 4Takeda Reports 1st Quarter Results of FY2015 with Underlying Revenue Growth of +6.1% 5Unilife Announces Multifaceted Financing Strategy 2Unilife Announces Multifaceted Financing Strategy 3Unilife Announces Multifaceted Financing Strategy 4Unilife Announces Multifaceted Financing Strategy 5Ascendis Pharma A/S to Report Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone and Host Conference Call on Thursday, July 30, 2015 at 9:00 a.m. Eastern Time 2
... STXS ) today announced that executive management will ... Tuesday, September 28, 2010 at 8:30 a.m. ET in New ... of the Company,s business strategy and recent corporate developments. ... A live audio and slides webcast of Stereotaxis, presentation may ...
... Instrumentation Laboratory (IL), today announced it will host the ... 2010 at the Grand Hyatt Nusa Dua, in Bali, Indonesia. ... local time.  The forum will focus on the latest clinical ... practicing in the Asia Pacific region are welcome to attend. ...
Cached Medicine Technology:Stereotaxis to Present at the JMP Securities Healthcare Conference 2Stereotaxis to Present at the JMP Securities Healthcare Conference 3Instrumentation Laboratory to Host 2nd Asia Pacific Hemostasis Forum 2Instrumentation Laboratory to Host 2nd Asia Pacific Hemostasis Forum 3Instrumentation Laboratory to Host 2nd Asia Pacific Hemostasis Forum 4
Reptilase-Time from Bothrops atrox...
Pefakit PiCT UFH Controls...
Pefakit PiCT LMWH Calibrators...
APTT (Ellagic Acid) - 10 ml...
Medicine Products: