Navigation Links
Mayo Clinic moves small-molecule drugs through blood-brain barrier
Date:6/4/2014

ROCHESTER, Minn. Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.

"Not only have we shown that we can transport eight different molecules, we think this method will be less disruptive or invasive because it mimics a normal physiological process," says Mayo Clinic neuroscientist Gobinda Sarkar, Ph.D., the corresponding author of the study. The researchers are able to transport the drugs without modifying any of the molecules involved. They say this development will aid in evaluation of potential new drugs for brain cancer.

The blood-brain barrier is meant to protect the brain from numerous undesirable chemicals circulating in the body, but it also obstructs access for treatment of brain tumors and other conditions. Too often the only recourse is invasive, which often limits a drug's effectiveness or causes irreversible damage to an already damaged brain. Nearly all of the drugs that could potentially help are too large to normally pass through the barrier. Additionally, other methods may damage the vascular system.

In this case, the synthetic peptide K16ApoE, once injected into a vein, binds to proteins in the blood to create entities that can pass for near-normal ligands to some receptors present on the blood-brain barrier. The 'pseudo-ligand' receptor interaction creates what the researchers believe to be transient pores through which various molecules can be transported to the brain. The molecules they've transported in this manner include cisplatin, methotrexate, cetuximab, three different dyes, and synthetic peptides Y8 and I-125. The researchers believe this is the least complicated, least expensive and most versatile method for delivering therapeutics to the brain. Previously, the researchers delivered antibodies targ
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. First targeted nanomedicine to enter human clinical studies
3. Clinical insight improves treatment with new lung cancer drug
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Mayo Clinic launches whole genome breast cancer study
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Mayo Clinic breast cancer study finds new type of mutation
9. Kroenke honored for outstanding contributions in clinical research training
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Association for Psychological Science, SAGE launch Clinical Psychological Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Jake W., 18, is completing his high ... Back2Basics Outdoor Adventures transition program known as Beyond the ... I can actually start on a real career path,” said ... done.” , He has six months of sobriety under his ... choose to continue on to the Beyond the Basics transition ...
(Date:8/30/2014)... 2014 “In 2013, a vehicle crash occurred ... says in a recently released article on 2013 Washington ... in an auto accident every 12 minutes, and a motorcyclist ... “Based on the 2013 statistics, between now and this same ... The threat of an auto accident is real and impending ...
(Date:8/30/2014)... FL (PRWEB) August 30, 2014 Zensah®, the ... Camo Compression Leg Sleeve . The camo sleeves are ... Leg Sleeve collection. The camo line includes classic colors ... and magenta. , Known as tibial stress syndrome, shin ... of the lower leg. Swollen and irritated muscles, stress fractures, ...
(Date:8/30/2014)... Barton Associates, an industry leading physician, ... , announces a new office location in Keene, NH, ... headquartered in Peabody, MA, with additional staffing centers in ... Jupiter, FL. , Barton Associates made the decision to ... crisis affecting the United States, a crisis that will ...
(Date:8/30/2014)... August 30, 2014 What challenges exist ... are the latest trends, concerns, and considerations? Sports ... Ken Pendleton recently spoke with Woody Wommack, Southeast Football ... current issues in football recruiting. Notably, Wommack spoke ... athletes, changes that he thinks are coming as a ...
Breaking Medicine News(10 mins):Health News:Startling Washington Auto Accident Statistics Discussed In Recently Released Article By The Jones Firm 2Health News:Camo Compression Leg Sleeves Provide Shin Splint Relief for Runners 2Health News:Barton Associates to Open a New Office Location in Keene, NH 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 2Health News:Woody Wommack of Rivals.com Discusses the World of NCAA Football Recruiting on SCI TV 3
... Now Available on Online Community to Facilitate Collaboration ... BEACH, Fla., May 8 With a growing ... short weeks since launch, e-Zassi.com has added an ... participants involved in the discovery, development and commercialization ...
... York City Raises Money for STAR (TM) ... Charcot-Marie-Tooth Association,s second annual "Honor a Star. Be a Star." ... achievement raised a record amount of over $350,000 at the ... Proceeds earned from event sponsorship, ticket sales and auction items ...
... One Global Health Threat"WASHINGTON, May 8 Today, HIV ... of Human Virology at the University of Maryland ... of the World Foundation for AIDS Research and Prevention, ... six objectives to end the HIV/AIDS pandemic. They ...
... -- Mindray Medical,International Limited (NYSE: MR ... devices worldwide announced today it filed with the,Securities ... 20-F that included,audited financial statements for the year ... Annual Report on Form 20-F is available online,at ...
... part of the Elekta Group, has been selected to ... the 2009 American Society of Clinical Oncology,s (ASCO) Annual ... County Convention Center, in Orlando, Florida. Chosen according to ... third consecutive year Impac Software ...
... May 8, 2009 AMERIGROUP Corporation (NYSE: ... the Deutsche Bank 34th Annual Healthcare Conference on May 18 ... Monday, May 18 at 2:25pm Eastern Time, can be accessed ... the investors, page. A replay will be available for 30 ...
Cached Medicine News:Health News:New Advanced Search and Matching Function Drives e-Zassi.com's Enhanced Functionality 2Health News:Charcot-Marie-Tooth Association's 'Honor a Star. Be a Star.' Gala Generates Over $350,000 for CMT Research 2Health News:A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier 2Health News:A Global Call to Action From HIV Co-Discoverers Robert Gallo and Luc Montagnier 3Health News:Mindray Files Annual Report on Form 20-F with U.S. Securities and Exchange Commission 2Health News:Impac Software Selected to Present at the Electronic Health Records Lab During 2009 ASCO Annual Meeting 2
(Date:8/29/2014)...  A Boston Scientific Corporation (NYSE: ... and preliminary long term stricture resolution of benign ... issue of the peer-reviewed journal, Gastroenterology. ... conducted in 11 countries and five continents, and ... (FCSEMS) after extended indwell (i.e., up to 12 ...
(Date:8/29/2014)... , Aug. 29, 2014 Thoratec Corporation ... device-based mechanical circulatory support therapies to save, support and ... in the 2014 Morgan Stanley Global Healthcare Conference on ... , President and Chief Executive Officer, will provide an ... Daylight Time (9:55 a.m., Pacific Daylight Time).   ...
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Peptide Cancer Therapeutics Market & Pipeline Insight ... The conventional methods developed to prevent and eradicate the ... treatment. These methods are confined to low specificity, safety ... researchers to look for a better solution. It has ...
Breaking Medicine Technology:Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2
... Sept. 23, 2011 A pharmaceutical company,s marketing strategy ... introducing a new brand in a space where the ... two-thirds of companies, the most frequent changes require shifting ... activities, such as professional relations, promotional literature, sampling, and ...
... 2011 Watson Pharmaceuticals, Inc. (NYSE: WPI ), ... Company intends to release its third quarter 2011 financial results ... the U.S. financial markets.  The Company will also host a ... November 1, 2011 to discuss its financial results and provide ...
Cached Medicine Technology:Pharmaceutical Marketing Strategy Balances Support Between New & Established Products in the Same Indication 2Watson to Host Conference Call and Webcast to Discuss Third Quarter 2011 Earnings 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: