Navigation Links
Mayo Clinic-led study: 2 drugs do not improve kidney function in acute heart failure patients
Date:11/18/2013

DALLAS -- Two drugs tested in a larger trial did not improve kidney function in acute heart failure patients, contrary to results of smaller studies. The results were presented today at the American Heart Association's Scientific Sessions 2013 in Dallas and simultaneously published in the Journal of the American Medical Association. Previous smaller studies showed that low-dose dopamine or low-dose nesiritide could improve kidney function and reduce fluid overload that is often present in hospitalized acute heart failure patients by increasing urine production.

In the Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE-AHF) randomized 26-site trial in the U.S. and Canada, researchers analyzed data on 360 hospitalized acute heart failure patients with kidney dysfunction from September 2010 to March 2013. Compared to placebo, researchers found that neither dopamine nor nesiritide, when also used with diuretic (water pills) therapy, was better at increasing urine volume or improving levels of serum cystatin-C, an indicator of kidney function, at the end of a 72-hour treatment.

"Kidney-enhancing therapies in acute heart failure continue to elude us," says Horng Chen, M.B., B.Ch., lead author and Mayo Clinic cardiologist. "In the past five years, all the major acute heart failure therapeutic clinical trials have not demonstrated beneficial effects of the therapies tested. This could be partly because the definition of acute heart failure is broad, and hence it includes a diverse group of patients."

Therefore, one take-away from the results of ROSE-AHF is that future studies in acute heart failure may need to target specific subgroups of these patients. For example, some patients have preserved ejection fraction, where the heart's lower chambers are stiff and cannot relax enough to fill fully between beats, and others may have reduced ejection fraction, where the heart is weak, Dr. Chen says.

Heart failur
'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-990-1182
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mayo Clinic-led study unravels biological pathway that controls the leakiness of blood vessels
2. Ability to metabolize tamoxifen affects breast cancer outcomes, Mayo Clinic-led study confirms
3. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
4. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
5. Study: Insomnia takes toll on tinnitus patients
6. Study: No link between depression, nasal obstruction
7. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
8. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
9. OHSU study: Misdiagnosis of MS is costing health system millions per year
10. UW study: Sleep apnea associated with higher mortality from cancer
11. Study: Heart damage after chemo linked to stress in cardiac cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... 2014) Population Council scientists and their partners have found ... can prevent the transmission of multiple sexually transmitted infections ... HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus ... that the gel is effective against multiple strains of ... vagina against all three viruses of at least eight ...
(Date:4/17/2014)... The world is less than 40 years away from ... people and governments, according to a top scientist at ... time in human history, food production will be limited ... water and energy," said Dr. Fred Davies, senior science ... issues could become as politically destabilizing by 2050 as ...
(Date:4/17/2014)... Belfast,s Vice-Chancellor, Professor Patrick Johnston, whose work has transformed ... a Fellow of the European Academy of Cancer Sciences., ... independent advisory body of highly distinguished oncologists and cancer ... caused by cancer in Europe. , Professor Johnston, whose ... move from the bottom of the UK league table ...
(Date:4/16/2014)... April 15, 2014 The Translational Genomics Research Institute ... annual Founders Dinner for their support of TGen,s research ... place March 28 in Scottsdale. , Catherine Ivy, Founder ... received TGen,s John S. McCain Leadership Award, named for ...
(Date:4/16/2014)... that fertility treatments are the leading cause of increases ... risk of premature birth, these results are not inevitable, ... . The article identifies six changes in policy ... births and prematurity, including expanding insurance coverage for in ...
Breaking Medicine News(10 mins):Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:TGen honors Catherine Ivy and Craig Jackson with Leadership; Collaborative Spirit awards 2Health News:Preterm births, multiples, and fertility treatment 2Health News:Preterm births, multiples, and fertility treatment 3
... Inc. (Nasdaq: SMBL ) announced today Steven Hughes, ... make a presentation at the Roth Capital Partners 21st Annual ... EST on Tuesday, February 17, 2009.Smart Balance,s presentation will be ... be able to ask questions, but listeners to the webcast ...
... from the clinical research community have already pledged ... American National Standards Institute (ANSI), coordinator ... is working to facilitate the use of electronic ... The Institute seeks the active engagement and financial ...
... Feb. 13 Dynatronics Corporation (Nasdaq: DYNT ) ... months ended December 31, 2008. Operating results showed significant improvement ... Pre-tax profit for the quarter ended December 31, 2008, improved ... the second quarter of the prior fiscal year. Net income ...
... BETHESDA, Md., Feb. 13 Micromet, Inc. (Nasdaq: MITI ), ... the ROTH 21st Annual Orange County Growth Stock Conference at the Ritz-Carlton ... The ROTH 21st Annual Orange County Growth Stock Conference, ... 4:30 pm Pacific Time, Place: The Ritz-Carlton ...
... SAN FRANCISCO, Feb. 13, 2009 New techniques used ... in the wild are yielding surprising results about hormones ... the social structure of a broader range of mammals. ... present findings at the AAAS meeting that examine social ...
... Applauds Senator Rockefeller and Representative Filner for Introducing ... Federation of Government Employees (AFGE) today applauded the ... the Senate Committee on Veterans, Affairs and Representative ... Veterans, Affairs for authoring legislation to amend Section ...
Cached Medicine News:Health News:ANSI Seeks Funding to Ensure that Electronic Health Records Will Support Clinical Research Activities 2Health News:ANSI Seeks Funding to Ensure that Electronic Health Records Will Support Clinical Research Activities 3Health News:ANSI Seeks Funding to Ensure that Electronic Health Records Will Support Clinical Research Activities 4Health News:Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results 2Health News:Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results 3Health News:Dynatronics Reports Profitable Second Quarter - Signaling Significant Improvement Over Prior Year Results 4Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 2Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 3Health News:Micromet To Present at the ROTH 21st Annual Orange County Growth Stock Conference 4Health News:Findings raise new questions about evolution of hormones in mammals 2Health News:Veterans' Affairs Employee Union Urges Congress to Strengthen Collective Bargaining Rights at VA Hospitals 2
(Date:1/15/2014)... plc (LSE: SHP, NASDAQ: SHPG ) announces that it ... the announced tender offer for all of the outstanding shares of ... the waiver, the transaction is no longer conditional on OFT approval, ... 2014 following the currently scheduled expiration time, subject to the satisfaction ...
(Date:1/15/2014)...  Manufacturers, suppliers and distributors of innovative medical-related products ... most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the Medical ... most litigious industry sectors of cases involving IP ...
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: ... concerning composition of matter, biological targets, mechanism of action, ... This patent application describes a novel ... (VSRNAs) which interfere with the basic homeostatic cellular processes ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
... Medical - SECRITT I Study to Evaluate Preventive Treatment ... Potentially Life Threatening Vulnerable Plaques, ... cardiology team led by Professor Patrick W. Serruys,successfully placed ... coronary artery of a 64-year-old man at Erasmus Medical,Center ...
... -- 10:00 a.m. EDT, 7:00 a.m. PDT ... -- 877-548-7901 ... http://www.isispharm.com , SAN DIEGO, June 30 Isis Pharmaceuticals,(Nasdaq: ISIS ) will conduct a ... TV-1102 clinical trial,and the ATL / TEVA / Isis relationship., -- ATL and TEVA announced clinical ...
Cached Medicine Technology:Patient Receives vProtect(TM) Luminal Shield in First-Ever Vulnerable Plaque Clinical Trial 2Patient Receives vProtect(TM) Luminal Shield in First-Ever Vulnerable Plaque Clinical Trial 3Isis Pharmaceuticals Conference Call Notice 2
... ML1 Manual Lensometer combines the traditional ... advantages, such as LED illumination and ... light source provides a clear green ... operated and completely cordless, the ML1 ...
... The Ultramatic RX Master Phoroptor ... - continues to be the industry standard ... that unmistakable feel of quality. The smooth ... of play in the mechanisms. The precise, ...
The Maverick Over-The-Wire balloon catheter delivers a new level of performance to meet the changing demands of interventional cardiology....
... The Illuminated Phoroptor features lighted dials ... to perform refractions in the darkened setting ... pen light and leave the lights off ... features lighted sphere, cylinder power and cylinder ...
Medicine Products: