Navigation Links
Mayo Clinic-led study: 2 drugs do not improve kidney function in acute heart failure patients
Date:11/18/2013

DALLAS -- Two drugs tested in a larger trial did not improve kidney function in acute heart failure patients, contrary to results of smaller studies. The results were presented today at the American Heart Association's Scientific Sessions 2013 in Dallas and simultaneously published in the Journal of the American Medical Association. Previous smaller studies showed that low-dose dopamine or low-dose nesiritide could improve kidney function and reduce fluid overload that is often present in hospitalized acute heart failure patients by increasing urine production.

In the Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE-AHF) randomized 26-site trial in the U.S. and Canada, researchers analyzed data on 360 hospitalized acute heart failure patients with kidney dysfunction from September 2010 to March 2013. Compared to placebo, researchers found that neither dopamine nor nesiritide, when also used with diuretic (water pills) therapy, was better at increasing urine volume or improving levels of serum cystatin-C, an indicator of kidney function, at the end of a 72-hour treatment.

"Kidney-enhancing therapies in acute heart failure continue to elude us," says Horng Chen, M.B., B.Ch., lead author and Mayo Clinic cardiologist. "In the past five years, all the major acute heart failure therapeutic clinical trials have not demonstrated beneficial effects of the therapies tested. This could be partly because the definition of acute heart failure is broad, and hence it includes a diverse group of patients."

Therefore, one take-away from the results of ROSE-AHF is that future studies in acute heart failure may need to target specific subgroups of these patients. For example, some patients have preserved ejection fraction, where the heart's lower chambers are stiff and cannot relax enough to fill fully between beats, and others may have reduced ejection fraction, where the heart is weak, Dr. Chen says.

Heart failure occurs when the heart doesn't pump blood as well as it should. Acute heart failure -- when heart failure patients require hospitalization -- is the most common cause of hospitalization in patients 65 years and older in the U.S., according to the American Heart Association.

"The study shows that as a one-size-fits-all therapy for acute heart failure patients with renal dysfunction, neither dopamine nor nesiritide improved the ability to get rid of excess fluid while protecting the kidneys in patients hospitalized for heart failure," says senior author Margaret Redfield, M.D., Mayo Clinic cardiologist. "The ROSE-AHF study suggests that these two drugs may have different effects in different types of heart failure. Future heart failure studies need to carefully assess the effect of therapies in specific types of patients as drugs may help some patients and not others."


'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-990-1182
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Mayo Clinic-led study unravels biological pathway that controls the leakiness of blood vessels
2. Ability to metabolize tamoxifen affects breast cancer outcomes, Mayo Clinic-led study confirms
3. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
4. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
5. Study: Insomnia takes toll on tinnitus patients
6. Study: No link between depression, nasal obstruction
7. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
8. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
9. OHSU study: Misdiagnosis of MS is costing health system millions per year
10. UW study: Sleep apnea associated with higher mortality from cancer
11. Study: Heart damage after chemo linked to stress in cardiac cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... Valentine’s Day is nearly upon ... the big day. A great outfit, flawless hair, and a sparkling personality are all ... resign themselves to a night at home with Rover. (Actually, man’s best friend might ...
(Date:2/13/2016)... (PRWEB) , ... February 13, 2016 , ... ... Infusion Nurses Society (INS) states that vein visualization technology should be used to ... healthcare facilities around the world, the INS Standards mandate the use of vein ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... According ... hernia surgeries are beginning to account for a significant portion of hernia repairs throughout ... Towfigh of the Beverly Hills Hernia Center notes that this trend has not only ...
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , Feb. ... , As Winston Churchill said, “Those who don’t learn from history are doomed to repeat ... when they come knocking this year. But that takes time. , Take a close ...
(Date:2/12/2016)... GA (PRWEB) , ... February 12, 2016 , ... ... relationship-marketing firm announced that nominations have closed for the ISE Southeast Awards 2016. ... will be announced at the ISE® Southeast Executive Forum and Awards Gala on ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016 On Thursday, Feb. 11, ... at St. David,s North Austin Medical Center successfully completed ... Xi ® Surgical System with Trumpf Medical,s ... Thiru Lakshman , M.D., colorectal surgeon at the ... utilizing Integrated Table Motion technology, which seamlessly combines the ...
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/11/2016)... Feb. 11, 2016 The primary goal of ... adoption patterns on the usage of liquid biopsy. Key ... - Timeframe of liquid biopsy adoption amidst ... and Evs—by organization type - Sample inflow to conduct ... saliva, stool, serum, and so on. - Correlation analysis ...
Breaking Medicine Technology: