Navigation Links
Mayo Clinic launches whole genome breast cancer study
Date:4/9/2012

ROCHESTER, Minn. -- The Breast Cancer Genome Guided Therapy Study (BEAUTY Project) will help physicians tailor chemotherapy to breast cancer patients based on their individual genomes and the genomes of their tumors. Mayo Clinic researchers will obtain three whole genome sequences: one from the patients' healthy cells before treatment, and two tumor genomes one before chemotherapy and one after. Patients will be paired with mouse "avatars" that will help physicians identify the best treatment for each person.

VIDEO ALERT: Audio and video resources are available on the Mayo Clinic News Blog(http://newsblog.mayoclinic.org/2012/04/05/mayo-clinic-launches-whole-genome-breast-cancer-study/).

"What is so exciting about this study is that it has the potential to really bring individualized medicine to our patients," says Matthew Goetz, M.D., Mayo oncologist and study co-leader. "It will transform how we conduct breast cancer research and how drug therapies are delivered to women with breast cancer."

In phase one of the BEAUTY Project, researchers will study the first 200 participants to look for common mutations that allow some tumors to adapt and thrive during chemotherapy. This information will help doctors identify new drugs and treatment strategies.

Women diagnosed with "high-risk" cancers who are scheduled to receive standard chemotherapy before surgery will have their healthy genome and their breast cancer tumor cells sequenced before treatment, and then receive the commonly prescribed chemotherapy to shrink the tumor. At surgery, the residual cancer tumor cells will be sequenced again to evaluate how they have mutated and adapted to chemotherapy.

In addition, patients' tumor tissue will be kept alive by implanting cell lines in immune-compromised mice -- before and after chemotherapy. The use of these mouse "avatars'' will let researchers study the effects of chemotherapy on individual patient tumors and identify the best treatment, without risk of harm to the patient.

"Patients are pleased after definitive breast surgery to be cancer free," says Judy Boughey, M.D., a Mayo breast surgeon and study co-leader. "Unfortunately, a subset of high-risk patients still may experience recurrence, even months or years later. We designed this study to give those patients hope that our ability to decode the genome of every patient might give us new tools to treat cancer."

Oncologists, surgeons, radiologists, and genomics and cancer researchers will work together to uncover the clues to effective individualized therapies and drug discovery. The BEAUTY Project is being funded by benefactors and the Mayo Clinic Center for Individualized Medicine, in collaboration with the Mayo Clinic Cancer Center.

"We are living in an era that I never thought I'd see during my career -- when we can sequence, in real time, the entire genome of a patient and her tumor and use that information to tailor treatment to the individual patient," says Richard Weinshilboum, M.D., director of the Pharmacogenomics Program in the Mayo Clinic Center for Individualized Medicine.

Together, the whole-genome sequencing data and transplanted cell lines are used to identify the gene pathways that influence individual patients' responses to chemotherapy. Armed with this deeper understanding of the genomics of cancer, doctors will be able to optimize treatment plans for individual patients.

This approach, called pharmacogenomics, is part of an ongoing effort at Mayo Clinic to personalize medicine for every patient and will help doctors prescribe the right drug for the right patient at the right dose and time. Additional work is being done in the Center for Individualized Medicine to develop clinical decision support tools to help doctors prescribe the best medication for each patient based on the latest pharmacogenomic knowledge.

Though initially being applied to breast cancer, this approach will be used in the future to study the treatment of many other types of cancer.


'/>"/>
Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Clinical news alert from the American Academy of Orthopaedic Surgeons
2. Clinical insight improves treatment with new lung cancer drug
3. First targeted nanomedicine to enter human clinical studies
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Early clinical data show galeterone safe, effective against prostate cancer
6. Cleveland Clinic study shows bariatric surgery improves, reverses diabetes
7. Stephanie R. Wilson, MD, to be presented with the Joseph H. Holmes Clinical Pioneer Award
8. Mayo Clinic researchers building melanoma vaccine to combat skin cancer
9. Mayo Clinic review: Blood pressure drug effective for treating PTSD-related nightmares
10. Standardized outcome measures proposed for asthma clinical research
11. Mayo Clinic: Robotic surgery proves successful, less invasive way to treat HPV-related oral cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks at ... his life to the fullest, as God intended. “The Adventures of Joey, The Dog ... and grandmother pursuing her passion for writing, especially about truth and human behavior. , ...
(Date:3/23/2017)... ... March 23, 2017 , ... A recent report from the National Council ... programs. The NCTQ report suggests, based on a review of GPA and SAT/ACT requirements ... quality in the U.S. It argues that this higher bar should be set by ...
(Date:3/23/2017)... ... 2017 , ... Demonstrating their commitment to improving health and ... have been awarded national accreditation through the Public Health Accreditation Board ... of communities across the nation whose health departments meet rigorous national standards for ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... Center at 10 North Broadway Avenue, will be an educational and exciting program ... instruction in the management of chronic pain. , Oklahoma is in a healthcare ...
(Date:3/23/2017)... and Grimsby, Ontario (PRWEB) , ... March 23, 2017 , ... The MBI “Hall of ... industry or whose acts have had a significant impact on the careers of all others ... Marketing with NRB Inc. was inducted into the MBI’s Hall of Fame. The induction ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 24, 2017  Zymo ... company, and Hamilton Robotics, Inc., who designs, ... an ongoing collaboration that teams Zymo Research,s ... RNA and DNA extraction products with Hamilton,s ... created optimized methods for microbiomics and RNA ...
(Date:3/24/2017)... 24, 2017 ShangPharma, a leading ... cost-effective drug development and discovery services, technology, ... industry, announced today the intent for a ... be consolidating the Contract Research Organizations (CRO) ... ChemPartner. These entities include ChemPartner Shanghai, ChemPartner ...
(Date:3/24/2017)... 24, 2017 A ReportsnReports.com report says, over ... rapidly as the global sales of Adcetris and Kadcyla have been ... antibody drug conjugates market is driven by large number of ADC ... therapeutic window offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 Major Company ...
Breaking Medicine Technology: