Navigation Links
Mayo Clinic identifies promising treatment for inherited form of kidney disease
Date:11/3/2012

SAN DIEGO -- A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented today at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine.

The multicenter study found tolvaptan demonstrated a nearly 50 percent reduction in the rate of increase in total kidney volume (a measurement of kidney cyst growth) in ADPKD patients over the study period, compared to placebo.

"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," says lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.

"In most patients with this disease, relentless cyst growth within the kidneys destroys the tissue, causes hypertension and painful complications, and negatively impacts the quality of life," Dr. Torres says. "The results of this study reveal a potential treatment that blunts kidney growth, lessens associated symptoms and slows kidney function decline when given over three years."

While the trial findings are encouraging, tolvaptan has not yet been approved for this indication, Dr. Torres notes.


'/>"/>

Contact: Rebecca Eisenman
newsbureau@mayo.edu
507-254-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Participation in clinical trials high among gay, lesbian and bisexual cancer survivors
2. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
3. Black patients received less clinical trial information than white patients
4. Barry D. Rutherford, M.D. presented with Master Clinical Operator Award at TCT 2012
5. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
6. Genetically-engineered preclinical models predict pharmacodynamic response
7. Cleveland Clinic study shows vitamin E may decrease cancer risk in Cowden syndrome patients
8. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
9. Clinic-based community program helps with childhood obesity
10. PARP inhibitors may have clinical utility in HER2-positive breast cancers
11. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 17, 2017 , ... For breast cancer clinicians and researchers who were unable ... a more intimate review and analysis of its highlights, a novel half-day, complimentary meeting—the ... by Imedex on February 4, 2017 in Chicago. Chaired by Kathy S. Albain, MD, ...
(Date:1/17/2017)... Village, IL (PRWEB) , ... January 17, 2017 ... ... musicians and music enthusiasts at the National Association of Music Merchants (NAMM) winter ... 19 – 22, 2017. , Etymotic’s ER•4® has long been the gold standard ...
(Date:1/17/2017)... ... 2017 , ... Peoples Health is pleased to announce that ... 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more than 55,000 ... our provider network, and the addition will benefit our members in the Greater ...
(Date:1/17/2017)... ... 2017 , ... Wettstein Agencies, a Denver area firm that ... central Colorado, is joining local nonprofit Aurora Warms The Night to provide services ... is committed to breaking the cycle of homelessness and poverty affecting a growing ...
(Date:1/17/2017)... ... January 17, 2017 , ... The Sharie Withers Agency, ... announced the latest beneficiary of their thriving community involvement program. The current campaign ... fulfilling the dreams of terminally ill patients. Donations to this worthy cause may ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... KANSAS CITY, Mo. , Jan. 17, 2017 ... selected Velos and its flagship technology platform Velos ... initiatives. CHNC is a benchmarking and ... Care Units at leading children,s hospitals across ... a benchmark of care and short-term outcomes for ...
(Date:1/17/2017)... Jan. 17, 2017 Following an initial ... praised the Food and Drug Administration,s (FDA,s) final ... Drug Products by Pharmacies and Outsourcing Facilities." In ... limitation on pre-packaging -- which would have put ... to long term care (LTC) pharmacies.  ...
(Date:1/17/2017)... 17, 2017  In a letter to President-elect ... Jenkins outlines AARP,s priorities for Americans age 50 ... access to affordable health care coverage, and lowering the ... Jenkins writes to President-elect Trump that "Our nearly 38 ... on you to protect their Medicare and Social Security ...
Breaking Medicine Technology: