Navigation Links
Mayo Clinic identifies promising treatment for inherited form of kidney disease
Date:11/3/2012

SAN DIEGO -- A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented today at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine.

The multicenter study found tolvaptan demonstrated a nearly 50 percent reduction in the rate of increase in total kidney volume (a measurement of kidney cyst growth) in ADPKD patients over the study period, compared to placebo.

"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," says lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.

"In most patients with this disease, relentless cyst growth within the kidneys destroys the tissue, causes hypertension and painful complications, and negatively impacts the quality of life," Dr. Torres says. "The results of this study reveal a potential treatment that blunts kidney growth, lessens associated symptoms and slows kidney function decline when given over three years."

While the trial findings are encouraging, tolvaptan has not yet been approved for this indication, Dr. Torres notes.


'/>"/>

Contact: Rebecca Eisenman
newsbureau@mayo.edu
507-254-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Participation in clinical trials high among gay, lesbian and bisexual cancer survivors
2. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
3. Black patients received less clinical trial information than white patients
4. Barry D. Rutherford, M.D. presented with Master Clinical Operator Award at TCT 2012
5. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
6. Genetically-engineered preclinical models predict pharmacodynamic response
7. Cleveland Clinic study shows vitamin E may decrease cancer risk in Cowden syndrome patients
8. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
9. Clinic-based community program helps with childhood obesity
10. PARP inhibitors may have clinical utility in HER2-positive breast cancers
11. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... TX (PRWEB) , ... July 24, 2017 , ... ... student scholarship will be awarded for the fall semester to a deserving student. ... Emergency Centers Spring 2017 scholarship was awarded to Mariana Castillo who is a nursing ...
(Date:7/24/2017)... ... July 24, 2017 , ... A ... destroyed the construction site and threatened numerous homes and businesses nearby, causing some ... on NBCLosAngeles.com. Los Angeles Area consulting firm Fire Protection Group, Inc. notes ...
(Date:7/24/2017)... ... , ... Axiad IDS , a leading provider of trusted identities for ... to expand its solution to help government contractors more quickly and cost-effectively comply ... to address the authentication requirements within NIST SP800-171, but no matter how you ...
(Date:7/24/2017)... ... July 24, 2017 , ... Puregraft, the global ... the issuance of United States Patent Number 9,695,398 (the '398 patent) and South ... The '398 and '324 patents cover methods and systems for optimizing fat grafts ...
(Date:7/24/2017)... Atlanta, Georgia (PRWEB) , ... July 24, 2017 ... ... first comprehensive sleep management solution focused on delivering end-to-end sleep health ... (OSA) program. , Recent literature shows that adherence rates for positive airway pressure ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 2017  MedX Holdings, Inc., the manufacturer and global ... rehabilitation equipment, today announced the national roll out of ... the gold standard for the treatment of low back ... equipment. How it ... or practice who prescribe the MedX Home Back Machine ...
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
(Date:7/11/2017)... -- Bayer has awarded grants totaling more than $2 million to ... Bayer Hemophilia Awards Program (BHAP). Four U.S. clinicians and researchers ... and Uniformed Services University of the Health Sciences in ... were announced last night during a reception at the International ... Berlin, Germany . ...
Breaking Medicine Technology: