Navigation Links
Mayo Clinic identifies promising treatment for inherited form of kidney disease
Date:11/3/2012

SAN DIEGO -- A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented today at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine.

The multicenter study found tolvaptan demonstrated a nearly 50 percent reduction in the rate of increase in total kidney volume (a measurement of kidney cyst growth) in ADPKD patients over the study period, compared to placebo.

"ADPKD is the most common inherited and the fourth most common overall cause of kidney failure worldwide," says lead author Vicente Torres, M.D., Ph.D., Mayo Clinic nephrologist.

"In most patients with this disease, relentless cyst growth within the kidneys destroys the tissue, causes hypertension and painful complications, and negatively impacts the quality of life," Dr. Torres says. "The results of this study reveal a potential treatment that blunts kidney growth, lessens associated symptoms and slows kidney function decline when given over three years."

While the trial findings are encouraging, tolvaptan has not yet been approved for this indication, Dr. Torres notes.


'/>"/>

Contact: Rebecca Eisenman
newsbureau@mayo.edu
507-254-5005
Mayo Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Participation in clinical trials high among gay, lesbian and bisexual cancer survivors
2. Mayo Clinic: Antidepressant eases radiation-related mouth pain in head, neck cancer
3. Black patients received less clinical trial information than white patients
4. Barry D. Rutherford, M.D. presented with Master Clinical Operator Award at TCT 2012
5. Mayo Clinic researchers develop new tools to better treat ADHD patients in early stages
6. Genetically-engineered preclinical models predict pharmacodynamic response
7. Cleveland Clinic study shows vitamin E may decrease cancer risk in Cowden syndrome patients
8. Mayo Clinic researchers identify new enzyme to fight Alzheimers disease
9. Clinic-based community program helps with childhood obesity
10. PARP inhibitors may have clinical utility in HER2-positive breast cancers
11. Maturitas publishes clinical guide on low-dose vaginal estrogens for vaginal atrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... , ... 38-Year-Old Plastic Surgeon Gill at Aesthetic Surgery Center is Saluted as ... that Plastic Surgeon Kiranjeet Gill has been awarded as one of the 15th annual ... that was started in 2003 to salute young achievers in Southwest Florida who have ...
(Date:9/21/2017)... ... ... SABRE is raising awareness about personal safety with a Chicago Transit Authority ... The Chicago, Illinois, based self-defense brand has been waiting for an opportunity like this ... their personal safety into their own hands. , The ads focus on their diverse ...
(Date:9/21/2017)... ... September 21, 2017 , ... Promotional Communication:, Keeping Up with ... In the competitive world of drug and device marketing and promotion, drug and ... rules. , The FDA has issued two draft guidances that are the closest ...
(Date:9/21/2017)... , ... September 21, 2017 , ... ... their communities, nine governmental public health departments have been awarded five-year accreditation status ... mean that the benefits of being served by a PHAB-accredited health department ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... or exercise more try taking a more holistic approach and use natural alternatives ... Amazon essential oil collection is certified USDA guaranteeing that, the new line of ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017   BioLife Solutions , Inc. ... marketer of proprietary clinical grade cell and tissue hypothermic ... that Mike Rice , President and CEO, will be ... Rodman & Renshaw 19 th Annual Global ... time (12:25 p.m. Pacific time). The conference is being held ...
(Date:9/6/2017)... 2017  Medical professionals are expected to ... treating their patients. Medical simulations offer clinicians ... patients. Simulation provides a safe method for ... procedures, refine techniques and build confidence, without ... technology, such as augmented reality, will now ...
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical stage ... Ideation and Behavior (ASIB), has been granted Fast Track status ... therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine + ... pivotal trial of this sequential therapy targeting patients who are ... ...
Breaking Medicine Technology: