Navigation Links
Mayo Clinic identifies a key cellular pathway in prostate cancer
Date:2/10/2014

ROCHESTER, Minn. Mayo Clinic researchers have shed light on a new mechanism by which prostate cancer develops in men. Central to development of nearly all prostate cancer cases are malfunctions in the androgen receptor the cellular component that binds to male hormones. The research team has shown that SPOP, a protein that is most frequently mutated in human prostate cancers, is a key regulator of androgen receptor activity that prevents uncontrolled growth of cells in the prostate and thus helps prevent cancer. The findings appear in the journal Cell Reports.

"By uncovering this new and important pathway of androgen receptor destruction, we may one day be able to develop more effective treatments for a substantial proportion of prostate cancer patients who have developed resistance to standard antiandrogen therapy," says Haojie Huang, Ph.D., Mayo Clinic biochemist and senior author of the paper.

SPOP mutations have been detected in approximately 15 percent of prostate cancer cases. In addition, it has been shown that in about 35 percent of prostate cancers, the SPOP protein is expressed at abnormally low levels. Despite its prevalence in prostate cancer, it was not known whether or how SPOP defects contributed to tumor development. What the research team discovered is that SPOP is an enzyme that selectively destroys androgen receptor protein. Failure to do so due to alterations in SPOP results in overabundance of androgen receptor, a master regulator of prostate cancer cell growth.

The Mayo Clinic research team made four major discoveries:

  • The antiandrogen receptor is a bona fide degradation substrate of SPOP.
  • Androgen receptor splicing variants are resistant to SPOP-mediated degradation.
  • Prostate cancer-associated SPOP mutants cannot bind to and promote androgen receptor degradation.
  • Androgens antagonize, but antiandrogens promote SPOP-mediated degradation of androgen receptor.

Pro
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
2. First targeted nanomedicine to enter human clinical studies
3. Clinical insight improves treatment with new lung cancer drug
4. Clinical news alert from the American Academy of Orthopaedic Surgeons
5. Mayo Clinic launches whole genome breast cancer study
6. Mayo Clinic offers newly approved treatment for acid reflux disease
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Mayo Clinic breast cancer study finds new type of mutation
9. Kroenke honored for outstanding contributions in clinical research training
10. Awards celebrate clinical research that can improve health and alleviate suffering
11. Association for Psychological Science, SAGE launch Clinical Psychological Science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... 03, 2015 , ... Illinois Health & Science (IHS) has completed the purchase ... includes all of IBAM NA’s cyclotron sites and research and development facilities. ... business, as well as a large manufacturing hub in Noblesville, Indiana,” said Ken Smithmier, ...
(Date:8/3/2015)... ... August 03, 2015 , ... Hub ... that Joe Williams has joined its growing California employee benefits division. Mr. ... model to his clients. Mr. Williams will be joining the newly integrated Northern ...
(Date:8/3/2015)... ... August 03, 2015 , ... Cambia Health Solutions has promoted ... the company’s Medicare and Federal Employee Programs (FEP) lines of business. , ... for members. In this role, Scott is responsible for overseeing the growth, finance ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... provider of medical information, risk management and investigative services, has introduced a ... toward focused, expert information solutions that improve business outcomes for its customers. ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... Did you ... or Orange County looking for exceptional and affordable home care options which A-1 Home ... are just a few of the credentials A-1 Home Care Agency is ...
Breaking Medicine News(10 mins):Health News:Illinois Health & Science Expands Nuclear Medicine Footprint With Purchase of IBA Molecular North America, Inc. 2Health News:HUB International Insurance Services Announces Joe Williams Has Joined its Northern California Employee Benefits Division 2Health News:Cambia Health Solutions Names Scott Powers President of Government Programs 2Health News:EMSI Announces New Branding: Powerful Information. Improved Outcomes. 2Health News:A-1 Home Care in Los Angeles and Orange County Honors Exceptional Office Staff 2Health News:A-1 Home Care in Los Angeles and Orange County Honors Exceptional Office Staff 3
... bird flu in northwestern Germany has been steadily increasing over ... 2 of the 103 cases were identified outside the Baltic ... have been involved in collection of carcasses. ,Recently, ... deadly virus. The Institute for Animal Health in Riems had ...
... might be able to reduce the harmful effects caused to ... reserachers at the Cornell// University. Foetal Alcohol Syndrome (FAS) results ... known cure for it. ,The reserachers say that ... ill effects of this particular syndrome. The researchers arrived at ...
... laid the foundation stone to construct a world-class cancer hospital ... come up at Rajarhat,// at the cost of Rs. 1.2 ... Centre (TMC) would come up on a 10-acre plot, West ... Tata said, after laying the foundation stone for the project ...
... than famous, is now going to face some competition. Private ... Canada, having garnered enough support from the several provinces in ... the Quebec government, which intended to remove the ban on ... offered to chip in and pick up costs for such ...
... which pertains to its French fries! Going by stats at ... use of wheat and milk as flavoring ingredients in French ... might trigger allergy in some individuals. ,Earlier, McDonald's also ... serving of fries is higher than previously estimated. ,The ...
... Kingdom: Pop Star Kelly, apart from lending her voice to ... cause of Breast cancer, with the authentic voice of personal ... Fund raising initiative in Staffordshire, England, Kelly, one of the ... support to the cause. , The Breast Cancer ...
Cached Medicine News:
(Date:8/3/2015)... , August 3, 2015 ... announced today that it has acquired ... Inc. for $300 million. With the acquisition, Shire ... drops combining 0.6% povidone iodine (PVP-I) and 0.1% ... treatment of infectious conjunctivitis, an ocular surface condition ...
(Date:7/31/2015)... CHAPEL HILL, N.C. , July 31, 2015 ... to product success in the biopharmaceutical market. Patients ... the process of selecting and switching therapies. This ... and is pushing marketers, efforts toward patient-focused marketing. ... to patient engagement, marketers have learned it,s important ...
(Date:7/31/2015)... 31, 2015 RnRMarketResearch.com adds ... research report that provides an overview of syringes ... sourced from in-house databases, secondary and primary research. ... market products pipeline spread across 124 pages, talking ... tables and 5 figures is now available at ...
Breaking Medicine Technology:Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 2Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 3Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 4Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 5Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 6Consumers Forcing Pharmaceutical Industry to Shift its Marketing Focus from Products to Patients 2Syringes and Needles Market Products Pipeline Review 2015 Report 2Syringes and Needles Market Products Pipeline Review 2015 Report 3Syringes and Needles Market Products Pipeline Review 2015 Report 4Syringes and Needles Market Products Pipeline Review 2015 Report 5
... Calif., Jan. 4, 2011 Intarcia Therapeutics, Inc. today ... will present at the 29th Annual JP Morgan Healthcare ... 2011 at the Westin St. Francis Hotel in San ... About Intarcia Intarcia Therapeutics, ...
... Pa., Jan. 4, 2011 Owner and medical director of ... her practice and is now offering Pixel Perfect™ ... CO2 laser from Alma Lasers. "I,m very ... Cirillo-Hyland said. "As a long time provider of aesthetic laser ...
Cached Medicine Technology:Intarcia Therapeutics Executive Chairman Kurt Graves to Present at 29th Annual JP Morgan Healthcare Conference 2Philadelphia's Victoria A. Cirillo-Hyland, M.D. Adds Alma Lasers' Pixel CO2 Laser System to Offer Fractional CO2 Laser Treatments to Patients 2
Extremely fine straight....
Curved delicate 5 mm blades....
Micro dressing forceps....
... The Leica M520 OH3 is ... best optical performance available on ... and unique stand. The Leica ... has the greatest range of ...
Medicine Products: