Navigation Links
Mayo Clinic genomic analysis lends insight to prostate cancer
Date:5/23/2013

ROCHESTER, Minn. -- Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings appear online today in the journal Cancer Research.

"This is the first study to examine DNA alterations using next generation sequencing in adjacent Gleason patterns in the same tumor allowing us to correlate genomics with changes in pathology," says John Cheville, M.D., Mayo Clinic pathologist and one of the authors on the paper.

The standard method of evaluating prostate cancer biopsy samples is a numerical scoring system called Gleason grading. A pathologist examines the tumor sample under the microscope, giving it a Gleason score based on the pattern of its cells. Since many prostate cancers contain more than one pattern, the two most common patterns are added together to provide the Gleason score. The Gleason score is the strongest predictor of outcome, with high scores indicating more aggressive prostate cancer. This study focused on Gleason patterns of three and four (Gleason score 7), a combination that indicates a cancer with increased risk of progression.

"While each pattern had its own breakpoints, they shared identical ones, which implies a common origin," Dr. Cheville says. DNA changes associated with aggressive prostate cancer were identified in the lower Gleason pattern, indicating that genomic changes occurred before they could be recognized by a pathologist. By understanding these lineage relationships within a tumor, he says, physicians will be better able to predict progression of the cancer and, in turn, better manage patients including those who chose no treatment but enter a follow-up program called active surveillance.

To determine relationships among the Gleason patterns of each tumor sample the team used laser capture micro dissection, whole genome a
'/>"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vancouver Skin Care Clinic Successfully Clears Pigmentation in Skin of Colour
2. CareAnyware and Cornell University Partner to Help Reduce Rehospitalizations by 39% in Clinically Depressed Home Health Patients
3. Pittsburgh Riverhounds Host First-Ever Watson Institute Special Kick Clinic
4. Find Urgent Care Launches New Site Design and Functionality to Provide Advanced Search Options for Users in Need of an Urgent Care Clinic
5. Two-day San Jose Dental Clinic Provides More Than $1.6 Million in Care
6. Fertility Clinics in Australia Industry Market Research Report Now Available from IBISWorld
7. Clearview Treatment Programs Clinical Director to Present on DBT and Substance Abuse at WCSAD
8. Mayo Clinic: How gold nanoparticles can help fight ovarian cancer
9. Workplace Options and Mayo Clinic Announce Strategic Relationship
10. Irregular Menses and Pain Caused by Adenomyosis or Endometriosis Can Be Improved with Herbal Therapy without Pain Killers & Surgeries - Wuhan Dr. Lee’s TCM Clinic
11. Mayo Clinic: Inflammatory bowel disease raises risk of melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... According to the article published July 27 on ... courthouse was contained and extinguished by the city’s fire department before it caused major damage ... the time of the fire, and it was a fire alarm system that tipped off ...
(Date:7/31/2015)... ... ... Well-known for its unique pastries and delicious confections, Pastry Palace, a popular ... life just a little bit sweeter for newlyweds. A family-owned business, the Pastry Palace ... , The bakery provides a full line of custom wedding cakes. Brides can select ...
(Date:7/31/2015)... ... 31, 2015 , ... Cosmetic Town has proven itself as ... plastic surgery procedures including, but not limited to, abdominoplasty, blepharoplasty, rhinoplasty and septoplasty. ... and fillers. , Staying up to date with the latest cosmetic trends ...
(Date:7/31/2015)... ... July 31, 2015 , ... The ... to patients and family members, medical professionals, and researchers, covering a variety of ... conference is a collaborative effort between the Mesothelioma Applied Research Foundation and Memorial ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Creating one of ... is in pursuit of a visionary image that goes beyond the boundaries of fertility ... Hope IVF has reached extraordinary heights with dependable patient support, affordable treatments, unending hope, ...
Breaking Medicine News(10 mins):Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2Health News:Cosmetic Town: Now Providing Interactive And Vital Medical Knowledge 2Health News:New York Area Mesothelioma Specialists to Present at Conference 2Health News:New York Area Mesothelioma Specialists to Present at Conference 3Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 2Health News:New Hope IVF Now Offers Most Affordable Assisted Reproductive Treatment in the UAE 3
... completely fabricated,item about GO3 Omega-3 fish oil capsules ... Star magazine, none of the parties named in ... magazine prior to publication., (Photo: http://www.newscom.com/cgi-bin/prnh/20080702/LAW528 ... and will vigorously pursue any,organization making false claims ...
... for Expansion of HIFU Technology, CHARLOTTE, N.C., ... provider of non-invasive high intensity focused ultrasound,for prostate ... acquisition,of Focus Surgery, Inc. (FSI) of Indianapolis, IN, ... image-guided acoustic ablation,device. This acquisition will accelerate USHIFU,s ...
... WASHINGTON, July 2 A Miami resident was,sentenced to ... to defraud the,Medicare program, Acting Assistant Attorney General Matthew ... Acosta of the Southern,District of Florida announced today., ... District Court for,the Southern District of Florida by Judge ...
... LAVAL, QC, July 2 /PRNewswire-FirstCall/ - Labopharm Inc. ... submitted a complete response to,the Food and Drug ... M.D., the FDA,s Deputy Director, Center for Drug ... the regulatory path towards,potential U.S. approval of the ...
... H. Fu, M.D., professor and chairman of the Department of Orthopaedic ... medical director of the University of Pittsburgh Medical Center (UPMC) for ... American Orthopaedic Society for Sports Medicine (AOSSM) on Saturday, July 12, ... , ...
... July 2 The Children,s Center is proud ... its Board of Directors --,Thomas C. Donohoe, Lance ... William Steffan. The board consists of civic, corporate ... shape,their futures., The Children,s Center also welcomes ...
Cached Medicine News:Health News:GO3 Statement Regarding Erroneous Coverage in Star Magazine 2Health News:USHIFU, LLC Completes Acquisition of Focus Surgery, Inc. 2Health News:Owner of Medical Equipment Company Sentenced to 130 Months in Prison for Health Care Fraud 2Health News:Owner of Medical Equipment Company Sentenced to 130 Months in Prison for Health Care Fraud 3Health News:Labopharm Submits Complete Response to FDA as a Result of Outcome of Appeal Process for Once-Daily Tramadol 2Health News:Reknowned Orthopaedic Surgeon to be Installed as President of Sports Medicine Society 2Health News:Reknowned Orthopaedic Surgeon to be Installed as President of Sports Medicine Society 3Health News:Reknowned Orthopaedic Surgeon to be Installed as President of Sports Medicine Society 4Health News:The Children's Center Announces Addition of Five New Board Members 2
(Date:7/31/2015)... , July 31, 2015 Today, ... (NABP ® ) issued a report urging ... that action is taken against websites illegally selling ... Internet Drug Outlet Identification Program Progress Report for ... , thousands of websites illegally distribute medications ...
(Date:7/31/2015)... 31, 2015 The Physician-Patient Alliance for ... July 28, 2015, "Surviving Your Hospital Stay: Physician-Patient ... Patient Safety." A sentence was omitted ... "PPAHS is a member of the National ... more information on the National Coalition to Promote ...
(Date:7/31/2015)... According to a new market research report " ... Oxide, Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables (Indicators, ... to 2020", published by MarketsandMarkets, The Sterilization Equipment Market is ... a CAGR of 7.6%.from 2015 to 2020. ... ables and 37 F igures ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4
15mm Open Blades, 28mm Maximum Spread; Available in small(S) and large (L), in stainless steel....
9mm Gently Curved Jaws, without lock; in Titanium....
8mm angled shaft with tip at 90 degree angle wtih rounded tear drop point; Tip available in left, right and center; (Right-SQT-225 and Left -SQT-227) In Titanium....
2.0mm Rounded Tip, 12mm From Tip to Bend Gently Curved, 15mm Shaft; In Titanium...
Medicine Products: