Navigation Links
Mayo Clinic finds switch that lets early lung cancer grow unchecked
Date:7/11/2012

JACKSONVILLE, Fla. Cellular change thought to happen only in late-stage cancers to help tumors spread also occurs in early-stage lung cancer as a way to bypass growth controls, say researchers at Mayo Clinic in Florida. The finding, reported in the July 11 issue of Science Translational Medicine, represents a new understanding of the extent of transformation that lung cancer and likely many other tumor types undergo early in disease development, the scientists say. They add that the discovery also points to a potential strategy to halt this process, known as epithelial-mesenchymal transition, or EMT.

"Our study points to EMT as a key step in lung cancer progression during the earliest stages of cancer development," says lead investigator and cancer biologist Derek Radisky, Ph.D.

"Normal cells recognize when they are dividing too rapidly, and turn on programs that block inappropriate cell division. Here we found that early-stage lung cancer cells switch on EMT in order to bypass these controls," he says.

The discovery could offer a new way to prevent progression to late-stage lung cancer, possibly by inhibiting a particular molecule from functioning, Dr. Radisky says.

Because EMT is a well-recognized late-stage transition that occurs in all sorts of solid tumors, the researchers say they believe that the same early-stage use of EMT they found in lung cancer is likely occurring in other cancers.

EMT is a biological process used in embryonic development to allow body development, which requires the ability of cells and tissues to morph from one type to another, and develop in an orchestrated fashion.

Late-stage cancer uses EMT to change tumor cells into a form that can migrate through blood.

"The gaps in our knowledge of lung cancer have not allowed us to develop more effective targeted therapies," Dr. Radisky says. "This study offers us great new clues for a new approach to treating lung an
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
2. Interactive personal health records increase clinical preventive services
3. University of Minnesota licenses Clinical Decision Support technology
4. Federally funded clinics for low-income patients as effective as private practices
5. Mayo Clinic YES Board creates efficiencies in emergency rooms
6. University of Louisville study dispels concerns about drive-thru flu clinics
7. Platelet drug shows clinical benefits for severe, unresponsive aplastic anemia
8. Washington Massage School Launches Private Practice Clinic
9. Rheumatoid arthritis takes high toll in unemployment, early death, Mayo Clinic finds
10. 40,000 Arizona student athletes receive concussion tests from Mayo Clinic
11. Mid-America Hand to Shoulder Clinic Offers Tips for a Safe Fourth of July
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... Metamora, Michigan (PRWEB) May 30, 2015 ... procedure to lighten or stop periods, without the ... This procedure can reduce or stop menstrual bleeding and ... the uterus (the part that causes the bleeding), with ... million women suffer from heavy menstrual bleeding. Many ...
(Date:5/30/2015)... Diego, CA (PRWEB) May 30, 2015 ... is the lack of local healthcare options available. Often, ... to adequate healthcare. For those in rural areas feeling ... simply without health insurance or tired of paying high ... new E-consults, connecting patients with licensed physicians via the ...
(Date:5/30/2015)... York (PRWEB) May 30, 2015 ... $100 million in punitive and compensatory damages to ... who suffered serious complications following implantation of the ... a verdict rendered on May 28th in Delaware ... in compensatory damages after the jury found that ...
(Date:5/30/2015)... EHO offers a suite of online applications ... the ability to manage their drug-spend for the lowest ... EHO has been able to compete with the big ... survive among the giants of the industry. Since EHO ... ago, it has simplified the way hospices can monitor ...
(Date:5/30/2015)... 30, 2015 Nicole Blodgett, Vice ... Income Associate (DIA) designation to further her expertise ... is designed for insurance advisors, health care professionals, ... knowledge and expertise associated with the risk and ... designation is only the latest accomplishment in Nicole's ...
Breaking Medicine News(10 mins):Health News:Women's Excellence Now Provides NovaSure Treatment 2Health News:Online USA Doctors Brings Healthcare to the Masses with New E-Consults 2Health News:Online USA Doctors Brings Healthcare to the Masses with New E-Consults 3Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 2Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 3Health News:Boston Scientific Transvaginal Mesh Lawsuit Trial Ends With $100 Million Verdict 4Health News:Secura Consultants Expands Disability Insurance Expertise 2
... University of Alabama at Birmingham (UAB) this month became ... cancer radiation therapy. The new technique can turn a ... patients. , Additionally, the new therapy saves healthy human ... the same or better than other radiotherapy techniques, according ...
... MEDI3) (MEDIAL SAUDE) announces the following webcast:, What: Medial Saude ... 2008 @ 12:00 PM EDT, Where: http://prnewswire.isat.com.br/?palestra_id=305 , How: ... the address above., ... Toll-free from the US: (1 800) 860-2442; ...
... might be swaying clinicians , , WEDNESDAY, May ... overdiagnosed, say researchers at Rhode Island Hospital and ... half of patients previously diagnosed with bipolar disorder ... -- the Structured Clinical Interview for DSM-IV (SCID). ...
... Shire plc (LSE: SHP, NASDAQ: SHPGY), the global ... new data analysis that was conducted to examine ... boys and girls aged 6 to 12 years ... findings from the analysis reaffirmed that DAYTRANA has ...
... Agrees to $2.3 million fine, CARMEL, Ind., ... ),today announced a settlement among state insurance regulators ... Insurance (CSHI) Company,and Bankers Life and Casualty Company. ... by Pennsylvania, Illinois,Indiana, Texas and Florida related to ...
... Vail Valley ... Medical Center, VAIL, Colo., May ... today the appointment of the new President,and CEO, John H. Cassin. Cassin ... Medical Center., "John brings great leadership experience and an engaging personal,style, ...
Cached Medicine News:Health News:UAB first in US to offer speedier precise cancer radiotherapy 2Health News:Bipolar Disorder Might Be Overdiagnosed 2Health News:New analysis shows DAYTRANA offered ADHD symptom control for 12 months 2Health News:New analysis shows DAYTRANA offered ADHD symptom control for 12 months 3Health News:Conseco Reaches Settlement of Multistate Market Conduct Examination 2Health News:Vail Valley Medical Center Board of Directors Announces Appointment of New President & CEO, John Cassin 2
(Date:5/29/2015)... and MENLO PARK, Calif. , ... Inc. (OTCQX: DMPI) ("DelMar" and the "Company"), ... proven cancer therapies in new orphan drug indications, ... Association of Cancer Research (AACR) Advances in Brain ... its lead product candidate VAL-083 (dianhydrogalactitol) ...
(Date:5/29/2015)... 29, 2015 Amgen (NASDAQ: AMGN ... Phase 3, global, randomized, placebo-controlled trials evaluating AMG ... secondary hyperparathyroidism (SHPT) in patients with chronic kidney ... primary endpoint, demonstrating that a greater proportion of ... greater than 30 percent reduction in parathyroid hormone ...
(Date:5/28/2015)... -- Eli Lilly and Company (NYSE: LLY ) announced today ... for up to $1.6 billion aggregate principal amount of certain ... who tendered, and did not validly withdraw, their notes on ... time, on May 27, 2015 (the early tender date), ... to receive the total consideration. The total consideration for each ...
Breaking Medicine Technology:DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 2DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 3DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 4DelMar Pharmaceuticals Presents Additional Data on the Potential of VAL-083 in the Treatment of Temozolomide-Resistant Glioblastoma Multiforme 5Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 2Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 3Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 4Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 5Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 6Amgen Presents Pooled Phase 3 AMG 416 Data For The Treatment Of Secondary Hyperparathyroidism In Patients With Chronic Kidney Disease 7Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 4Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 5
... Amgen (Nasdaq: AMGN ) reported revenue unchanged ... $3,812 million for the third quarter of 2009. ... the third quarter of 2010 compared to $1,518 million for ... income was driven by unusually low research and development (R&D) ...
... 25 See video from Novartis: ... New Phase III data indicate that Menveo® (Meningococcal ... demonstrated robust immunogenicity in infants potentially offering protection ... 3. These data were presented during an oral ...
Cached Medicine Technology:Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 2Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 3Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 4Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 5Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 6Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 7Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 8Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 9Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 10Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 11Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 12Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 13Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 14Amgen’s Third Quarter 2010 Revenue Unchanged at $3.8 Billion Versus Prior Year 15
Diagnosoft HARP is designed for rapid analysis of tagged cardiac MR images using the HARP technology, which is packaged into an intuitive, easy-to-use graphic user interface....
With MediLive MindStream you can make, cut and edit digital videos, add commentaries and notes, and save them. MediLive MindStream - intuitive user interface and high-resolution monitor all in one....
... Monitor is the smartest, toughest and most ... an on-board artificial intelligence algorithm, DiogenesTM, the ... arrhythmias while on the patient. The Decipher ... all the rigorous tests required to monitor ...
... Afinion HbA1c test and the ... you reliable facts conveniently available ... them. Advising the patient can ... The HbA1c Test Cartridge contains ...
Medicine Products: