Navigation Links
Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
Date:4/30/2013

"This is a gene that is highly active in a lot of other cancers and it may be that the agent we tested could provide new clinical avenues in those cancers as well," von Roemeling says.

The experimental drug, A939572, is a targeted inhibitor of SCD1 protein. "We found it to be incredibly specific to cancer cells in laboratory mice treated with the agent," Dr. Copland says. "But these are early days in the testing of this agent for cancer."

Not only is SCD1 active in some cancers, it also is being investigated for its role in promoting obesity and diabetes, the researchers say. Scientists are also testing A939572 as an antidote to those conditions.

The Mayo Clinic scientists performed a genome screen of tissue samples from 150 kidney cancer patient tissue samples, which represented all stages of cancer progression, to identify genes that are significantly overexpressed, compared to noncancerous tissue samples. SCD1 was one of their top finds.

They then disabled SCD1 in laboratory kidney cancer cells and found that the tumor cells stopped growing and a large percentage died.

Next, researchers tested A939572 and the federally approved kidney cancer drug temsirolimus. They found that using either agent alone cut tumor growth by up to 25 percent in mice studies, but using both drugs together, and at lower doses, reduced it 60 to 70 percent.

"The synergy between the drugs was very striking, suggestive of significant clinical benefit in patients," Dr. Copland says.

Von Roemeling says that SCD1 protein expression offers a novel molecular prognostic biomarker in kidney cancer that could guide therapy.

The study was funded by National Cancer Institute grants R01CA104505, R01CA136665 and R01CA104505-05S1; the David & Lois Stulberg Endowed Fund for Kidney Cancer Research; Mr. and Mrs. Ompal Chauhan Kidney Cancer Research Fund; Kidney Cancer Research at
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experts discuss ways to embed patient voices and values in clinical research
2. Trinity Health Selects Explorys’ Big Data Analytics Platform to Support Clinical Integration and Quality Initiatives
3. Cleveland Clinic research shows Internet-based program effective in reducing stress
4. Cloud Computing in Pharmaceutical Research and Development - Virtualization of Data through the Cloud Optimizes Next-Generation DNA Sequencing and Clinical Trials Data
5. Contract Research Organization WCCT Global Announces Overwhelming Success of Pediatric Clinical Study Recruitment
6. Mayo Clinic creates institution-wide electronic prolonged QT interval warning system
7. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
8. Illinois-based OSF HealthCare joins Mayo Clinic Care Network
9. Cleveland Clinic Childrens Hospital research suggests transmission of respiratory viruses in utero
10. Clinical Trials Helped One Womans Fight Against Cancer
11. National awards celebrate clinical research achievements in the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... (PRWEB) September 30, 2014 Speaking on ... OMICS Group observed ‘Nursing Conference’ as a remarkable event, ... and medium medical and clinical research and diagnostic companies, ... conference as a perfect platform to share experience, foster ... around the world. Nursing Conference is a forum to ...
(Date:9/30/2014)... 2014 MyMobileUni seeks to partner globally ... have similar shared vision to transform individuals and empower ... (MMU):, , to impact ... all ages , to have focused channels ... to promote equal access to education and ...
(Date:9/30/2014)... bowel cancer for a genetic condition would cut their ... research has found. , In a major study, Dr ... researchers from the University of Exeter,s Medical School assessed ... a genetic condition known as Lynch Syndrome. ... changes in genes which check the spelling in DNA. ...
(Date:9/30/2014)... This two-day, advanced PT continuing ... that may arise following a concussion or mild ... be varied, from sports related injuries, car accidents, falls, ... the thousands of returning soldiers from war zone regions. ... blunt traumas can result in similar injuries, the course ...
(Date:9/30/2014)... Sheridan Healthcare, Inc. , ... today announced that Adam Blomberg, MD, the national ... present at the Society for Healthcare Strategy & ... . The conference will be held October 12-15 ... a four-day conference that draws in more than ...
Breaking Medicine News(10 mins):Health News:Exploring New Possibilities to Take Nursing Profession to Great Heights 2Health News:Exploring New Possibilities to Take Nursing Profession to Great Heights 3Health News:MyMobileUniversity Call to Public and Private Organisations, NGOs’ and Individuals: Catalyze Positive Social Change, Let’s Transform Individuals and Empower Communities 2Health News:MyMobileUniversity Call to Public and Private Organisations, NGOs’ and Individuals: Catalyze Positive Social Change, Let’s Transform Individuals and Empower Communities 3Health News:Genetic test would help 'cut bowel cancer spread' 2Health News:Genetic test would help 'cut bowel cancer spread' 3Health News:North American Seminars Presents Traumatic Brain Injury and Concussions in Conduction with St. Anthony's Medical Center in St. Louis, MO on November 8-9, 2014 2Health News:North American Seminars Presents Traumatic Brain Injury and Concussions in Conduction with St. Anthony's Medical Center in St. Louis, MO on November 8-9, 2014 3Health News:Sheridan Healthcare Anesthesiologist to Present at Society for Healthcare Strategy & Market Development Conference 2Health News:Sheridan Healthcare Anesthesiologist to Present at Society for Healthcare Strategy & Market Development Conference 3
... ... of “medication adherence.” , ... Alexandria, VA (Vocus) April 10, 2010 -- An article in the prestigious New ... Association of Chain Drug Stores’ (NACDS) message that pharmacy’s role in helping patients take ...
... 2010 - PANDAS is an abbreviation for Pediatric ... This diagnosis was created when clinicians observed that ... fever, and impetigo, children developed tics and symptoms ... study appearing in Biological Psychiatry , published ...
... Many doctors misinterpret critical numbers, researchers say , ... the results of a test used to detect chronic ... test, which looks for serum alanine aminotransferease (ALT) activity, ... by medication. But doctors vary in their assessment of ...
... panel believes genetic studies may reveal why soldiers from ... -- The cluster of symptoms experienced by some veterans of ... causes, treatment and potential cure remain unknown, concludes a new ... , However, newer medical technology, including the ability examine genetic ...
... ... Handling of Hazardous Drugs , ... COLUMBUS, OH (Vocus) April 9, 2010 -- You’ve heard of the Safety ... Handling Awareness Month (April), Carmel Pharma, Inc. and the oncology healthcare staff at Novant ...
... by acetyl-salicylic acid (ASA) consumption is a common ... proposed to ameliorate different gastrointestinal tract diseases such ... etc. However, little attention has been paid to ... health-promoting effects ascribed to probiotic strains or fermented ...
Cached Medicine News:Health News:New England Journal of Medicine Article Trumpets “Priority” Status of Helping Patients Take Medications Correctly 2Health News:New England Journal of Medicine Article Trumpets “Priority” Status of Helping Patients Take Medications Correctly 3Health News:PANDAS don't like stress 2Health News:Liver Disease May Go Undetected in Children 2Health News:Gulf War Syndrome Is Real, But Causes Unclear: Report 2Health News:Gulf War Syndrome Is Real, But Causes Unclear: Report 3Health News:Gulf War Syndrome Is Real, But Causes Unclear: Report 4Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 2Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 3Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 4Health News:Now Live! The “Safe Handling Dance” Video to Benefit ASHP/ONS Foundations 5
(Date:9/30/2014)... Sept. 30, 2014  Synapse Biomedical Inc. ( www.synapsebiomedical.com ) ... the post-approval study of its NeuRx DPS® System ... meet the FDA enrollment requirement was implanted over ... The NeuRx DPS®, which is the only medical ... patients, is a humanitarian device that obtained approval ...
(Date:9/30/2014)... Sept. 30, 2014  eHealth, electronic access of ... access of this information, has become a major ... that has not translated into user-friendly, effective products. ... - http://photos.prnewswire.com/prnh/20140929/149123 For ... years developing MWD® Health Manager iEHR, a multilingual ...
(Date:9/30/2014)... Sept. 30, 2014 It is evident from the ... is not performing upto expectations due to the lack of ... with the intake of omega-3 fatty acids. Among omega-3 ingredient ... fish oil, attributed to the large vegetarian population in ... polyunsaturated fatty acid (PUFAs) ingredients is in growth stage of ...
Breaking Medicine Technology:Synapse Biomedical Announces the Early Completion of Enrollment in the FDA Post Approval Study for ALS Patients 2Synapse Biomedical Announces the Early Completion of Enrollment in the FDA Post Approval Study for ALS Patients 3MWD Challenges the Big eHealth Players With New Software for Your Smartphone 2Omega-3 Polyunsaturated Fatty Acids (PUFAs) - An Indian Market Overview 2
... The 2009 Frost & Sullivan European Medical ... the radiology applications market is conferred on Viatronix ... the diagnostic imaging space. , (Logo: ... Viatronix has shown dedication to both developing and ...
... PAC, a leading global provider of advanced analytical instruments ... of the ANTEK MultiTek(TM) testing system for the fast, ... and halides. Industries include BioFuels, Chemicals, Food & Beverage, ... , "MultiTek(TM) is the only instrument on the ...
Cached Medicine Technology:Frost & Sullivan Lauds Viatronix as European Medical Imaging Emerging Company of the Year 2Frost & Sullivan Lauds Viatronix as European Medical Imaging Emerging Company of the Year 3Frost & Sullivan Lauds Viatronix as European Medical Imaging Emerging Company of the Year 4New ANTEK MultiTek(TM) by PAC Provides Fast, All-in-One Testing for Sulfur, Nitrogen, Halides 2
... this is the universal lithotripter for ... urinary and biliary treatment. The system ... with other applications including cystoscopy, ureteronoscopy, ... system comprises the height adjustable urologist' ...
... This therapeutic system ... the patient in mind. ... surgery and ongoing therapy, ... low-risk and effective therapy. ...
... Reach a new dimension! That of the ... unequalled performance and ease of use. Enjoy ... electroconductive shock wave technology coupled with the ... system. Manage the patient treatment, X-ray and ...
... The MINILITH SL1 developed by STORZ ... of extensive experience in the field of ... of the specific requirements to be met ... therapy, as has been outlined above. The ...
Medicine Products: