Navigation Links
Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
Date:4/30/2013

JACKSONVILLE, Fla. Researchers at Mayo Clinic's campus in Florida have discovered a protein that is overly active in every human sample of kidney cancer they examined. They also found that an experimental drug designed to block the protein's activity significantly reduced tumor growth in animals when used alone. Combining it with another drug already used to treat the cancer improved the effectiveness of both.

The findings, reported in the April 30 online issue of Clinical Cancer Research, offer a much-needed potential new direction for the treatment of clear cell renal cell carcinoma, which accounts for almost 85 percent of kidney cancer cases in the United States. More than 57,000 diagnoses of kidney cancer occur yearly in the U.S. with greater than 13,000 deaths.

"There is a clear need for new therapies for this common cancer. With very few exceptions, patients inevitably become resistant to all available treatments," says the study's senior investigator, molecular biologist John Copland, Ph.D.

Their findings might be relevant to the treatment of other cancers, says Christina von Roemeling, the study's lead author. The protein they identified is produced by the stearoyl CoA desaturase 1 (SCD1) gene, which has also been found to be over active in a number of other cancers, including lung, stomach, breast, prostate, ovary and colon cancers.


'/>"/>
Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Experts discuss ways to embed patient voices and values in clinical research
2. Trinity Health Selects Explorys’ Big Data Analytics Platform to Support Clinical Integration and Quality Initiatives
3. Cleveland Clinic research shows Internet-based program effective in reducing stress
4. Cloud Computing in Pharmaceutical Research and Development - Virtualization of Data through the Cloud Optimizes Next-Generation DNA Sequencing and Clinical Trials Data
5. Contract Research Organization WCCT Global Announces Overwhelming Success of Pediatric Clinical Study Recruitment
6. Mayo Clinic creates institution-wide electronic prolonged QT interval warning system
7. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
8. Illinois-based OSF HealthCare joins Mayo Clinic Care Network
9. Cleveland Clinic Childrens Hospital research suggests transmission of respiratory viruses in utero
10. Clinical Trials Helped One Womans Fight Against Cancer
11. National awards celebrate clinical research achievements in the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Juvent Sports ... at the 2015 PGA Merchandise Show to bestow a ... incredible female amateur golfer, Arlene McKitrick. The award commemorated ... amateur golf tournament win. She won her first amateur ...
(Date:1/22/2015)... January 22, 2015 Thousand of GranuFlo ... Care recalled its GranuFlo and NaturaLyte dialysis concentrates continue ... in U.S. District Court, District of Massachusetts, Bernstein Liebhard ... the Court has remanded a case filed by the ...
(Date:1/22/2015)... over 20 years, Dr. David Cruz of Cruz Chiropractic Care ... just about every type of injury that can result from car ... twenty-plus years, the team at Doctors on Liens has ... doctor. With the combined breadth of experience between the ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2
... have received grants from the California Institute for Regenerative ... treating diabetes and brain tumors. The intent of ... applications to the U.S. Food and Drug Administration within ... The two grants, awarded to collaborative scientific teams, total ...
... statins protect heart during infection , THURSDAY, Oct. 29 (HealthDay ... also help prevent death from severe flu, a new study ... evidence suggests that statins -- which include medicines such as ... infections. Whether they help with flu, however, has been more ...
... Oct. 29 Abbott (NYSE: ABT ) announced ... Improvement Award for environmental excellence. It is the ... efforts to safeguard the environment and integrate sustainability initiatives ... Illinois are an important part of our broader work ...
... WASHINGTON, Oct. 29 Bread for the World President Rev. ... Africa and Global Health to make ending hunger, child and ... an empowered, distinct development voice their top priorities. , ... this morning during a hearing in Congress. He said that ...
... therapies, which claim to use subtle energy to stimulate ... reducing the intensity of pain in a number of ... behaviors in dementia, over and above what standard treatments ... Shamini Jain, from the UCLA Division of Cancer Prevention ...
... 29 VIA Pharmaceuticals, Inc. (Nasdaq: VIAP ... of compounds for the treatment of cardiovascular and ... Senior Vice President Research & Development will present ... Disease", and will discuss the Company,s cardio-metabolic product ...
Cached Medicine News:Health News:UCSF diabetes, brain tumor stem cell grants to drive development of therapies 2Health News:UCSF diabetes, brain tumor stem cell grants to drive development of therapies 3Health News:UCSF diabetes, brain tumor stem cell grants to drive development of therapies 4Health News:Cholesterol Drugs May Help Prevent Flu Deaths 2Health News:Abbott Receives Sustainability Award for Continued Efforts to Protect the Environment in Illinois 2Health News:Abbott Receives Sustainability Award for Continued Efforts to Protect the Environment in Illinois 3Health News:Bread for the World Urges House Committee to Support U.S. Global Hunger Initiative 2Health News:Biofield therapies: Helpful or full of hype? 2Health News:VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference 2Health News:VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference 3Health News:VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference 4Health News:VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference 5
(Date:1/22/2015)... , Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: ... the first member of the new Simple Plex platform ... This launch represents the re-branding of the previously acquired ... Plex platform is a transformative immunoassay technology which integrates ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ... Disease Diagnostics Market by Product, Application, Technology, End User ... offering. , The infectious disease diagnostics market ... reach $18,156.2 million by 2019 from $12,422.8 million in ...
(Date:1/22/2015)... Parenteral Drug Association (PDA) today announced the launch of its ... Future. The Manufacturing Science Program SM ... the ongoing focus PDA has on pharmaceutical and biopharmaceutical manufacturing. ... gaps in current manufacturing science as well as gaps that ...
Breaking Medicine Technology:Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3PDA Launches Manufacturing Science Program(SM) 2PDA Launches Manufacturing Science Program(SM) 3
... 14 Following an announcement from,Schering-Plough, Roche ... in combination with ribavirin as the market-leading,treatment ... United States and globally.,Despite clear biases in ... potentially,favored patients taking Peg-Intron(TM) (peginterferon alfa-2b) regimens ...
... Kibow Biotech, Inc. is pleased to,announce that ... Cooperation,Treaty (PCT) patent from Australia, China and ... and their Method of use for Gut-based,Therapy," ... Company,s oral,probiotic product formulation (Kibow Biotics(R)) which ...
Cached Medicine Technology:Roche responds to announcement of 'IDEAL' hepatitis C trial results 2Roche responds to announcement of 'IDEAL' hepatitis C trial results 3Roche responds to announcement of 'IDEAL' hepatitis C trial results 4Roche responds to announcement of 'IDEAL' hepatitis C trial results 5Roche responds to announcement of 'IDEAL' hepatitis C trial results 6Roche responds to announcement of 'IDEAL' hepatitis C trial results 7Kibow Biotech Obtains Australian, Chinese and Indian Patents Protecting the Composition and Basic Technology Behind Its Oral Probiotic Formulation for Chronic Kidney Failure 2Kibow Biotech Obtains Australian, Chinese and Indian Patents Protecting the Composition and Basic Technology Behind Its Oral Probiotic Formulation for Chronic Kidney Failure 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: