Navigation Links
Mayo Clinic estimates new, tiny, super-sensitive probe could cut colon polyp removal in half
Date:10/7/2008

JACKSONVILLE, Fla. Based on results of a landmark study, researchers at Mayo Clinic's Florida campus see a future in which virtual biopsies will eliminate the need to remove colon polyps that are not cancerous or will not morph into the disease.

Currently one-third to one-half of the polyps removed during colonoscopies end up being harmless, but they need to be examined by pathologists, and this increases time, expense and the potential for complications to the beneficial screening.

At the annual meeting of the American College of Gastroenterology, Mayo Clinic gastroenterologists will present final details of a study testing a probe so sensitive that it can tell if a cell in the colon is becoming cancerous or not. They specifically found that the system, known as probe-based confocal laser endomicroscopy (pCLE), was 90 percent accurate in identifying benign or harmless polyps in patients. With further tweaking, the researchers believe pCLE can reach about 100 percent accuracy.

"Our goal is to remove only cancerous or precancerous polyps from patients during a colonoscopy, and I think we are close to that," says the study's lead investigator, Michael Wallace, M.D., M.P.H., professor of medicine at Mayo Clinic.

Mayo Clinic has been the U.S. leader in testing pCLE, among other endoscopic imaging technologies, and is one of three international institutions to have tested it in colon polyps. The system has been used under a research protocol for several years at Mayo. Now, physicians are starting to use it more broadly, especially to re-examine the colon in patients who previously had large, precancerous polyps removed and in pre-cancerous conditions elsewhere in the GI tract, such as Barrett's esophagus, Dr. Wallace says.

In this study, the researchers tested two different new imaging systems against the gold standard, which is examination of a removed polyp by a pathologist. "Using the expertise of a pathologist has been a great way to determine if a polyp is dangerous, but because half of these growths are not dangerous, we are seeking an equally effective and more efficient way to determine who is at risk of colon cancer," says the study's lead research fellow, Anna M. Buchner, M.D., who will present the results.

The pCLE system is a fiber-optic probe 2 millimeters in diameter that can be passed through a normal endoscope and can see structures as small as 1 micron, such as single cells or the nucleus within a cell. "This is essentially a miniaturized microscope that can be placed inside the body, so the tissue doesn't need to be removed and placed under a traditional microscope," Dr. Wallace says. The pCLE system, which was developed by Mauna Kea Technologies (Paris, France), was tested against the Fujinon color enhancement system (FICE), which uses optical filters to look at a larger area of tissue. "This is like looking at the forest using FICE or the trees with pLCE," Dr. Wallace says.

A total of 57 polyps from 38 patients were examined. The FICE technique correctly diagnosed 41 of 57 polyps as benign, whereas pLCE picked up 51 of the benign lesions.

The researchers believe that the best use of these advanced technologies is to use FICE to provide a first look at suspicious areas of a colon during a colonoscopy and then to use pCLE to zero in on polyps in question.

"These new probes will change how colonoscopies and other procedures using endoscopes will be done in the future," says Dr. Buchner. "We will be able to perform real-time virtual biopsies, which will be more efficient in every way." One major advantage is that the pCLE system allows doctors to make a specific diagnosis at the time of the procedure and thus go directly to treatment instead of waiting two to three days for biopsy results to return. This should allow patients to avoid repeat procedures, Dr. Wallace says.


'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. ProGenTech Targets Clinical Diagnostics and Applied Sciences Markets with Human Genetic Signatures Deal
2. Clinical Outsourcing Leaders Summit Set to Convene November 13
3. Jefferson awarded multi-million dollar grant from National Eye Institute for new clinical trial
4. VA Announces Ten National Sponsors for New Sports Clinic
5. Austin Dentistry Clinic Now Offers Certified Full Service Sedation Dentistry -- All Gain, No Pain
6. MultiVu Video Feed: NEW RESEARCH PUBLISHED IN THE AMERICAN JOURNAL OF CLINICAL NUTRITION FINDS PISTACHIOS IMPROVE RISK FACTORS FOR HEART DISEASE
7. Urgent Care Provider NextCare Opens First Immediate Care Clinic in Texas
8. Mayo Clinic Announces 2008 Distinguished Alumni Awardees
9. What is the clinical features of primary aortoenteric fistula?
10. Medicare HMO costs may prevent cancer patient clinical trial participation
11. Popular Denver Divas Host to Manage the New American Laser Centers Clinic in Arvada
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
Breaking Medicine Technology: